Literature DB >> 27368095

Evidence of G.O.D.'s Miracle: Unearthing a RAG Transposon.

Martin F Flajnik1.   

Abstract

Diversity of antibodies and T cell receptors is generated by gene rearrangement dependent on RAG1 and RAG2, enzymes predicted to have been derived from a transposable element (TE) that invaded an immunoglobulin superfamily gene early in the evolution of jawed vertebrates. Now, Huang et al. report the discovery of ProtoRAG in the lower chordate Amphioxus, the long-anticipated TE related to the RAG transposon.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27368095      PMCID： PMC5428540          DOI： 10.1016/j.cell.2016.06.021

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

1.  Sequences at the somatic recombination sites of immunoglobulin light-chain genes.

Authors:  H Sakano; K Hüppi; G Heinrich; S Tonegawa
Journal:  Nature       Date:  1979-07-26       Impact factor: 49.962

2.  A brief history of the status of transposable elements: from junk DNA to major players in evolution.

Authors:  Christian Biémont
Journal:  Genetics       Date:  2010-12       Impact factor: 4.562

Review 3.  New insights into V(D)J recombination and its role in the evolution of the immune system.

Authors:  C B Thompson
Journal:  Immunity       Date:  1995-11       Impact factor: 31.745

Review 4.  The invention of lymphocytes.

Authors:  Ellen Hsu
Journal:  Curr Opin Immunol       Date:  2011-01-10       Impact factor: 7.486

5.  The V(D)J recombination activating gene, RAG-1.

Authors:  D G Schatz; M A Oettinger; D Baltimore
Journal:  Cell       Date:  1989-12-22       Impact factor: 41.582

Review 6.  The origins of the Rag genes--from transposition to V(D)J recombination.

Authors:  Sebastian D Fugmann
Journal:  Semin Immunol       Date:  2009-12-09       Impact factor: 11.130

7.  An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1.

Authors:  Yanni Zhang; Ke Xu; Anqi Deng; Xing Fu; Anlong Xu; Xiaolong Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-24       Impact factor: 11.205

8.  RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons.

Authors:  Vladimir V Kapitonov; Jerzy Jurka
Journal:  PLoS Biol       Date:  2005-05-24       Impact factor: 8.029

9.  Collaboration of RAG2 with RAG1-like proteins during the evolution of V(D)J recombination.

Authors:  Lina Marcela Carmona; Sebastian D Fugmann; David G Schatz
Journal:  Genes Dev       Date:  2016-04-07       Impact factor: 11.361

10.  Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination.

Authors:  Shengfeng Huang; Xin Tao; Shaochun Yuan; Yuhang Zhang; Peiyi Li; Helen A Beilinson; Ya Zhang; Wenjuan Yu; Pierre Pontarotti; Hector Escriva; Yann Le Petillon; Xiaolong Liu; Shangwu Chen; David G Schatz; Anlong Xu
Journal:  Cell       Date:  2016-06-09       Impact factor: 41.582
  10 in total
  4 in total

Review 1.  A cold-blooded view of adaptive immunity.

Authors:  Martin F Flajnik
Journal:  Nat Rev Immunol       Date:  2018-07       Impact factor: 53.106

2.  Analysis of shark NCR3 family genes reveals primordial features of vertebrate NKp30.

Authors:  Allison Kinlein; Morgan E Janes; Jacob Kincer; Tereza Almeida; Hanover Matz; Jianxin Sui; Michael F Criscitiello; Martin F Flajnik; Yuko Ohta
Journal:  Immunogenetics       Date:  2021-03-19       Impact factor: 3.330

3.  Rearranged T Cell Receptor Sequences in the Germline Genome of Channel Catfish Are Preferentially Expressed in Response to Infection.

Authors:  Robert Craig Findly; Frank D Niagro; Ryan P Sweeney; Alvin C Camus; Harry W Dickerson
Journal:  Front Immunol       Date:  2018-09-27       Impact factor: 7.561

4.  LanceletDB: an integrated genome database for lancelet, comparing domain types and combination in orthologues among lancelet and other species.

Authors:  Leiming You; Jiaqi Chi; Shengfeng Huang; Ting Yu; Guangrui Huang; Yuchao Feng; Xiaopu Sang; Xinhui Gao; Ting'an Li; Zirui Yue; Aijie Liu; Shangwu Chen; Anlong Xu
Journal:  Database (Oxford)       Date:  2019-01-01       Impact factor: 3.451
  4 in total

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