Stefan Schob1, Alexey Surov2, Andreas Wienke3, Hans Jonas Meyer2, Rolf Peter Spielmann2, Eckhard Fiedler4. 1. Department of Neuroradiology, University Hospital of Leipzig, Liebigstraße 20, 04103, Leipzig, Germany. stefan.schob@medizin.uni-leipzig.de. 2. Department of Radiology, University Hospital of Leipzig, Liebigstraße 20, 04103, Leipzig, Germany. 3. Institute of Medical Epidemiology, Biometry, and Statistics, Martin-Luther-University Halle-Wittenberg, Halle, Germany. 4. Department of Dermatology and Pathology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Abstract
PURPOSE: Diffusion-weighted imaging (DWI) measures water diffusion in biological tissues. Cellular water transport depends on aquaporins (AQPs). The expression of aquaporins might differ in several pathologic disorders. Therefore, the aim of this study was to evaluate the associations between AQP4 expression and different DWI parameters in meningioma. PROCEDURES: Twenty-three patients with meningioma grade I were included in this retrospective study. DWI was obtained with three b values (0; 500; 1000) using a 1.5-T device. ADCmean, ADCmin, ADCmax, and true diffusion coefficients (D) were obtained in every patient. Aquaporin 4 expression was quantified immunohistochemically in four immunoreactivity levels. RESULTS: The estimated DWI parameters (mean value ± standard deviation, 10-3 mm2 s-1) of the tumors were as follows: ADCmin 0.67 ± 0.16, ADCmean 0.94 ± 0.23, ADCmax 1.29 ± 0.50, and D 0.65 ± 0.23. The mean level of the AQP4 expression was 2.02 ± 0.75 points. A statistically significant correlation between AQP4 expression and ADCmax was identified (r = 0.508, p = 0.013). No significant correlations between AQP4 and other DWI parameters were found. CONCLUSIONS: A clear correlation between AQP4 expression and ADCmax values in grade I meningioma was identified. There were no significant correlations between AQP4 expression and other DWI parameters, such as ADCmin, ADCmean, and D.
PURPOSE: Diffusion-weighted imaging (DWI) measures water diffusion in biological tissues. Cellular water transport depends on aquaporins (AQPs). The expression of aquaporins might differ in several pathologic disorders. Therefore, the aim of this study was to evaluate the associations between AQP4 expression and different DWI parameters in meningioma. PROCEDURES: Twenty-three patients with meningioma grade I were included in this retrospective study. DWI was obtained with three b values (0; 500; 1000) using a 1.5-T device. ADCmean, ADCmin, ADCmax, and true diffusion coefficients (D) were obtained in every patient. Aquaporin 4 expression was quantified immunohistochemically in four immunoreactivity levels. RESULTS: The estimated DWI parameters (mean value ± standard deviation, 10-3 mm2 s-1) of the tumors were as follows: ADCmin 0.67 ± 0.16, ADCmean 0.94 ± 0.23, ADCmax 1.29 ± 0.50, and D 0.65 ± 0.23. The mean level of the AQP4 expression was 2.02 ± 0.75 points. A statistically significant correlation between AQP4 expression and ADCmax was identified (r = 0.508, p = 0.013). No significant correlations between AQP4 and other DWI parameters were found. CONCLUSIONS: A clear correlation between AQP4 expression and ADCmax values in grade I meningioma was identified. There were no significant correlations between AQP4 expression and other DWI parameters, such as ADCmin, ADCmean, and D.
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