Literature DB >> 35715607

The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy.

Mohammad Behnam1, Alireza Motamedzadeh2, Marzieh Aalinezhad3, Ehsan Dadgostar4,5, Fatemeh Zahra Rashidi Noshabad1, Mohammad Pourfridoni6, Maedeh Raei7, Hamed Mirzaei8, Michael Aschner9, Omid Reza Tamtaji10,11.   

Abstract

Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO-Kyn-AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.

Entities:  

Keywords:  Aquaporin 4; Astrocytoma; Glioblastoma; Glioma; Meningioma

Year:  2022        PMID： 35715607     DOI： 10.1007/s11033-022-07656-y

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  52 in total

Review 1.  Targeting inflammation-induced transcription factor activation: an open frontier for glioma therapy.

Authors:  Ellora Sen
Journal:  Drug Discov Today       Date:  2011-09-06       Impact factor: 7.851

Review 2.  Epilepsy associated tumors: Review article.

Authors:  Marco Giulioni; Gianluca Marucci; Matteo Martinoni; Anna Federica Marliani; Francesco Toni; Fiorina Bartiromo; Lilia Volpi; Patrizia Riguzzi; Francesca Bisulli; Ilaria Naldi; Roberto Michelucci; Agostino Baruzzi; Paolo Tinuper; Guido Rubboli
Journal:  World J Clin Cases       Date:  2014-11-16       Impact factor: 1.337

Review 3.  The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.

Authors:  David N Louis; Arie Perry; Guido Reifenberger; Andreas von Deimling; Dominique Figarella-Branger; Webster K Cavenee; Hiroko Ohgaki; Otmar D Wiestler; Paul Kleihues; David W Ellison
Journal:  Acta Neuropathol       Date:  2016-05-09       Impact factor: 17.088

Review 4.  Input of molecular analysis in medical management of primary brain tumor patients.

Authors:  A Idbaih; A Duran-Peña; C Bonnet; F Ducray
Journal:  Rev Neurol (Paris)       Date:  2015-05-27       Impact factor: 2.607

Review 5.  Lipoma with Agenesis of Corpus Callosum: 2 Case Reports and Literature Review.

Authors:  Salah Ben Elhend; Hatim Belfquih; Nabil Hammoune; El Mehdi Athmane; Abdelilah Mouhsine
Journal:  World Neurosurg       Date:  2019-01-28       Impact factor: 2.104

6.  A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.

Authors:  Zhi Sheng; Li Li; Lihua J Zhu; Thomas W Smith; Andrea Demers; Alonzo H Ross; Richard P Moser; Michael R Green
Journal:  Nat Med       Date:  2010-05-23       Impact factor: 53.440

7.  Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells.

Authors:  Hongyu Zhang; Xiaoxia Kong; Jinsong Kang; Jing Su; Yang Li; Jiateng Zhong; Liankun Sun
Journal:  Toxicol Sci       Date:  2009-05-18       Impact factor: 4.849

Review 8.  Brain metastasis.

Authors:  Adrienne Boire; Priscilla K Brastianos; Livia Garzia; Manuel Valiente
Journal:  Nat Rev Cancer       Date:  2019-11-28       Impact factor: 60.716

9.  Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo.

Authors:  Khalid Shah; Yi Tang; Xandra Breakefield; Ralph Weissleder
Journal:  Oncogene       Date:  2003-10-09       Impact factor: 9.867

Review 10.  Headaches and brain tumors.

Authors:  Sarah Kirby; R Allan Purdy
Journal:  Neurol Clin       Date:  2013-12-27       Impact factor: 3.806
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