| Literature DB >> 27351370 |
Katherine S McGilton1,2, Charlene H Chu1,2, Gary Naglie1,3,4,5, Paula M van Wyk6, Steven Stewart1, Aileen M Davis4,7,8,9.
Abstract
OBJECTIVES: To determine the contribution of cognitive impairment, prefracture functional impairment, and treatment as predictors of functional status and mobility 6 months after discharge from rehabilitation for older adults with hip fracture.Entities:
Keywords: cognitive impairment; dementia, rehabilitation models of care; hip fracture; long-term rehabilitation outcomes; person-centered models of care
Mesh:
Year: 2016 PMID: 27351370 PMCID: PMC6680258 DOI: 10.1111/jgs.14297
Source DB: PubMed Journal: J Am Geriatr Soc ISSN: 0002-8614 Impact factor: 5.562
Characteristics of Study Population According to Level of Cognitive Impairment
| Characteristic | Combined, n = 133 | No Cognitive Impairment, n = 101 | Mild to Moderate Cognitive Impairment, n = 23 | Severe Cognitive Impairment, n = 9 |
|---|---|---|---|---|
| Age, n (%) | ||||
| 64–74 | 33 (25) | 26 (26) | 7 (30) | 0 (0) |
| 75–84 | 50 (38) | 41 (41) | 6 (26) | 3 (33) |
| ≥85 | 50 (38) | 34 (43) | 10 (28) | 6 (67) |
| Age, mean ± SD | 81.0 ± 7.9 | 80.8 ± 8.1 | 80.2 ± 8.5 | 84.6 ± 3.7 |
| Female, % | 77 | 81 | 57 | 88 |
| Education <12 years, % | 17 | 15 | 26 | 11 |
| Married or common‐law partner, % | 41 | 35 | 52 | 33 |
| Living with others % | 50 | 53 | 39 | 44 |
| Health status and physical function, % | ||||
| Diagnosed dementia | 16 | 7 | 39 | 56 |
| ≥3 chronic conditions | 83 | 82 | 91 | 78 |
| History of falls | 68 | 63 | 83 | 78 |
| Previous fall with injury | 55 | 52 | 68 | 67 |
| MMSE score at admission, mean ± SD | 24.6 ± 4.6 | 26.3 ± 2.5 | 20.6 ± 3.3 | 14.6 ± 7.9 |
| MMSE score at discharge, mean ± SD | 25.5 ± 4.6 | 27.6 ± 1.7 | 21.6 ± 1.6 | 12.9 ± 5.5 |
| Older American Resources and Service Instrument score, mean ± SD | 23.7 ± 5.4 | 25.1 ± 4.2 | 20.9 ± 3.8 | 15.2 ± 9.4 |
| Type of hip fracture, % | ||||
| Intertrochanteric | 39 | 43 | 39 | 0 |
| Intracapsular | 49 | 45 | 48 | 100 |
| Subtrochanteric | 2 | 2 | 4 | 0 |
| Other | 10 | 11 | 9 | 0 |
| Wheelchair required at discharge, % | 13 | 11 | 22 | 11 |
| Reported pain at discharge, % | 22 | 22 | 26 | 11 |
| Site 1 (of two alternative sites), % | 42 | 44 | 39 | 33 |
| Intervention care, % | 46 | 46 | 48 | 44 |
N = 133 because 12 participants had missing data.
SD = standard deviation; MMSE = Mini‐Mental State Examination.
Figure 1Patient Centered Rehabilitation Model‐Cognitive Impairment model of care (PCRM‐CI) participant study flow diagram.
Change in Outcomes from Admission Through 6 Months After Discharge for Each Category of Cognitive Impairment at Discharge
| Outcome | No Cognitive Impairment, n = 101 | Mild to Moderate Cognitive Impairment, n = 23 | Severe Cognitive Impairment, n = 9 |
|---|---|---|---|
| Mean ± Standard Deviation | |||
| Independence in activities of daily living (FIM Self‐care Subscale; possible range 8–56) | |||
| Admission | 41.5 ± 8.6 | 39.2 ± 8.7 | 32.4 ± 11.5 |
| Discharge | 51.6 ± 4.7 | 49.0 ± 8.3 | 37.2 ± 13.2 |
| 3 months after discharge | 52.7 ± 7.0 | 43.1 ± 13.4 | 29.3 ± 16.1 |
| 6 months after discharge | 53.2 ± 4.6 | 46.5 ± 11.1 | 35.8 ± 15.6 |
| Functional mobility (FIM Mobility Subscale; possible range 5–35) | |||
| Admission | 13.5 ± 5.3 | 12.3 ± 5.2 | 11.0 ± 6.5 |
| Discharge | 25.2 ± 4.9 | 24.1 ± 6.0 | 17.0 ± 8.2 |
| 3 months after discharge | 28.3 ± 5.2 | 22.6 ± 7.9 | 18.2 ± 9.4 |
| 6 months after discharge | 29.0 ± 4.7 | 25.5 ± 7.6 | 19.8 ± 9.0 |
| Environmental Mobility (New Mobility Scale; possible range 0–9 | |||
| Admission | 3.4 ± 1.2 | 3.0 ± 1.4 | 2.2 ± 1.1 |
| Discharge | 4.3 ± 1.0 | 4.1 ± 1.3 | 3.6 ± 1.3 |
| 3 months after discharge | 6.2 ± 2.1 | 5.0 ± 2.8 | 4.6 ± 2.2 |
| 6 months after discharge | 6.7 ± 1.9 | 5.8 ± 3.0 | 4.7 ± 2.1 |
FIM = Functional Independence Measure.
Multilevel Mixed‐Effects Multivariate Regression Results Comparing Outcomes 3 and 6 Months After Discharge with Those at Discharge (Repeated Measures on N = 133 Participants)
| Predictor | Independence in Activities of Daily Living (FIM Self‐care Subscale) | Functional Mobility (FIM Mobility Subscale) | Environmental Mobility (New Mobility Scale) |
|---|---|---|---|
| Unstandardized Beta (95% Confidence Interval) | |||
| Average effect on outcome from discharge to 6 months after discharge | |||
| Participant characteristics | |||
| Age | –0.01 (–0.14–0.11) | –0.08 (–0.17–0.01) | 0.01 (–0.01–0.02) |
| Female | 1.89 (–0.55–4.34) | 1.81 (0.01–3.60) | 0.24 (–0.14–0.62) |
| Married or partner | –1.43 (–3.46–0.61) | 0.74 (–0.75–2.23) | 0.27 (–0.04–0.59) |
| <High school education | –0.07 (–2.74–2.60) | –1.88 (–3.83–0.07) | –0.14 (–0.56–0.28) |
| Participant health status at admission | |||
| Number of comorbidities | –0.40 (–1.07–0.27) | –0.39 (–0.87–0.10) | 0.03 (–0.07–0.14) |
| Prefracture functional impairment | –0.12 (–0.35–0.11) | –0.25 (–0.43 to –0.06) | –0.11 (–0.14 to –0.07) |
| Participant health status at discharge | |||
| Required wheelchair at discharge | –5.41 (–8.32 to –2.51) | –3.54 (–5.68 to –1.41) | –0.99 (–1.45 to –0.54) |
| Pain reported at discharge | –0.29 (–0.72–0.14) | –0.44 (–0.75 to –0.12) | –0.08 (–0.15 to –0.02) |
| Severity of cognitive impairment at discharge | |||
| Severe cognitive impairment | –12.94 (–17.44 to –8.44) | –5.43 (–9.10 to –1.76) | 0.26 (–0.41–0.93) |
| Mild to moderate cognitive impairment | –0.74 (–3.56–2.09) | 0.88 (–1.42–3.18) | 0.34 (–0.08–0.76) |
| Patient Centered Rehabilitation Model‐Cognitive Impairment model of care | –0.42 (–2.33–1.48) | –0.47 (–1.87–0.92) | 0.30 (0.00–0.59) |
| Site difference | –0.37 (–2.32–1.57) | 0.95 (–0.46–2.36) | 0.07 (–0.23–0.37) |
| Pattern of change over time: interactions with each measurement time | |||
| Interaction between each category of cognitive impairment and each measurement time (reference discharge) | |||
| No cognitive impairment × 3 months after discharge | 3.93 (1.94–5.92) | 4.44 (2.96–5.93) | 2.54 (2.10–2.98) |
| No cognitive impairment × 6 months after discharge | 3.28 (1.37–5.19) | 4.38 (2.77–5.98) | 2.76 (2.28–3.24) |
| Mild to moderate cognitive impairment × 3 months after discharge | –3.25 (–6.91–0.41) | –2.76 (–5.60–0.00) | –0.28 (–1.08–0.51) |
| Mild to moderate cognitive impairment × 6 months after discharge | –3.46 (–7.04–0.12) | –1.79 (–4.78–1.20) | –0.24 (–1.15–0.66) |
| Severe cognitive impairment × 3 months after discharge | 0.70 (–7.56–6.16) | 1.59 (–3.36–6.53) | 0.09 (–1.30–1.49) |
| Severe cognitive impairment × 6 months after discharge | 1.42 (–5.08–7.92) | 0.65 (–4.69–6.00) | –0.27 (–1.81–1.27) |
| Interaction between prefracture functional impairment and each measurement time (reference discharge) | |||
| Prefracture functional impairment × 3 months after discharge | –0.67 (–0.97 to –0.37) | –0.36 (–0.58 to –0.14) | –0.14 (–0.20 to –0.07) |
| Prefracture functional impairment × 6 months after discharge | –0.53 (–0.82 to –0.24) | –0.27 (–0.51 to –0.06) | –0.12 (–0.20 to –0.05) |
| Constant | 53.65 (42.86–64.44) | 30.55 (22.65–38.46) | 3.69 (2.00–5.37) |
| Random‐effects parameters | |||
| SD among repeated measures within participants | 4.02 (3.14–5.14) | 2.53 (1.78–3.61) | 0.69 (0.49–0.96) |
| SD of residual variation at discharge | 3.96 (3.06–5.14) | 3.88 (3.20–4.71) | 0.48 (0.25–0.93) |
| SD of residual variation at 3 months after discharge | 6.49 (5.49–7.68) | 3.94 (3.22–4.83) | 1.66 (1.45–1.90) |
| SD of residual variation at 6 months after discharge | 5.45 (4.31–6.87) | 4.18 (3.42–5.10) | 1.65 (1.43–1.90) |
| Correlation between repeated measures at discharge and 3 months after discharge | 0.12 (–0.08–0.32) | 0.05 (–0.15–0.25) | 0.29 (0.05–0.49) |
| Correlation between repeated measures 3 months and 6 months after discharge | 0.72 (0.57–0.83) | 0.68 (0.51–0.79) | 0.74 (0.65–82) |
Cognitive impairment measured according to Mini‐Mental State Examination; prefracture functional impairment measured according to Older Americans Resources and Services instrument.
P < a.05, b.01, c.001.
FIM = Functional Independence Measure; SD = standard deviation.
Figure 2Change in outcomes from admission through 6 months after discharge for each category of cognitive impairment. Black markers present unadjusted values and show the contribution of cognitive impairment and prefracture functional impairment. White markers depict the adjusted changes (removed effect of prefracture functional impairment) to illustrate the influence of cognitive impairment alone. FIMS = Functional Independence Measure Self‐care Subscale; FIMM = Functional Independence Measure Mobility Subscale; NMS = New Mobility Scale.