Literature DB >> 27341658

Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus.

Matthew D Stephens1, Nisakorn Yodsanit2, Christian Melander1.   

Abstract

A small molecule library consisting of 45 compounds was synthesized based on the bacterial metabolite ethyl N-(2-phenethyl) carbamate. Screening of the compounds revealed a potent analogue capabale of inhibiting several strains of Methicillin Resistant S. aureus biofilms with low to moderate micromolar IC50 values.

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Year:  2016        PMID： 27341658      PMCID： PMC4942382          DOI： 10.1039/c6ob00706f

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  20 in total

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2.  Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates.

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3.  Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents.

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4.  Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms.

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5.  Evaluation of 4,5-disubstituted-2-aminoimidazole-triazole conjugates for antibiofilm/antibiotic resensitization activity against MRSA and Acinetobacter baumannii.

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Journal:  ChemMedChem       Date:  2011-09-16       Impact factor: 3.466

6.  N-substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization.

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Journal:  Org Biomol Chem       Date:  2013-01-07       Impact factor: 3.876

7.  A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of β-lactams against multi-drug resistant bacteria.

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Journal:  Eur J Med Chem       Date:  2012-12-20       Impact factor: 6.514

8.  Synthesis and antibiofilm activity of marine natural product-based 4-thiazolidinones derivatives.

Authors:  Rajesh A Rane; Niteshkumar U Sahu; Chetan P Shah
Journal:  Bioorg Med Chem Lett       Date:  2012-10-03       Impact factor: 2.823

Review 9.  The global threat of antimicrobial resistance: science for intervention.

Authors:  I Roca; M Akova; F Baquero; J Carlet; M Cavaleri; S Coenen; J Cohen; D Findlay; I Gyssens; O E Heuer; G Kahlmeter; H Kruse; R Laxminarayan; E Liébana; L López-Cerero; A MacGowan; M Martins; J Rodríguez-Baño; J-M Rolain; C Segovia; B Sigauque; E Tacconelli; E Wellington; J Vila
Journal:  New Microbes New Infect       Date:  2015-04-16

10.  Augmenting anti-cancer natural products with a small molecule adjuvant.

Authors:  Paul G Wahome; Kevin R Beauchesne; Anna C Pedone; John Cavanagh; Christian Melander; Paul Zimba; Peter D R Moeller
Journal:  Mar Drugs       Date:  2014-12-26       Impact factor: 5.118
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  2 in total

1.  Investigations into the carbonic anhydrase inhibition of COS-releasing donor core motifs.

Authors:  Andrea K Steiger; Yu Zhao; Won Jin Choi; Alder Crammond; McKinna R Tillotson; Michael D Pluth
Journal:  Biochem Pharmacol       Date:  2017-11-10       Impact factor: 5.858

Review 2.  Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition.

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Journal:  Front Cell Infect Microbiol       Date:  2019-04-02       Impact factor: 5.293
  2 in total

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