Literature DB >> 19194596

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates.

Robert W Huigens1, Steven A Rogers, Andrew T Steinhauer, Christian Melander.   

Abstract

A chemically diverse library of TAGE-triazole conjugates was synthesized utilizing click chemistry on the TAGE scaffold. This library of small molecules was screened for anti-biofilm activity and found to possess the ability of inhibiting biofilm formation against Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa. One such compound in this library demonstrated the most potent inhibitory effect against Staphylococcus aureus biofilm formation that has been displayed by any 2-aminoimidazole derivative.

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Year:  2009        PMID： 19194596     DOI： 10.1039/b817926c

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  12 in total

1.  Marine sponge alkaloids as a source of anti-bacterial adjuvants.

Authors:  Roberta J Melander; Hong-Bing Liu; Matthew D Stephens; Carole A Bewley; Christian Melander
Journal:  Bioorg Med Chem Lett       Date:  2016-11-09       Impact factor: 2.823

2.  Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents.

Authors:  Steven A Rogers; Robert W Huigens; John Cavanagh; Christian Melander
Journal:  Antimicrob Agents Chemother       Date:  2010-03-08       Impact factor: 5.191

3.  Nitazoxanide inhibits biofilm formation by Staphylococcus epidermidis by blocking accumulation on surfaces.

Authors:  Florence Tchouaffi-Nana; T Eric Ballard; Christine H Cary; Timothy L Macdonald; Costi D Sifri; Paul S Hoffman
Journal:  Antimicrob Agents Chemother       Date:  2010-04-19       Impact factor: 5.191

4.  Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus.

Authors:  Matthew D Stephens; Nisakorn Yodsanit; Christian Melander
Journal:  Org Biomol Chem       Date:  2016-07-12       Impact factor: 3.876

Review 5.  Biologically inspired strategies for combating bacterial biofilms.

Authors:  Meghan S Blackledge; Roberta J Worthington; Christian Melander
Journal:  Curr Opin Pharmacol       Date:  2013-07-18       Impact factor: 5.547

Review 6.  Productive steps toward an antimicrobial targeting virulence.

Authors:  Amy K Barczak; Deborah T Hung
Journal:  Curr Opin Microbiol       Date:  2009-07-22       Impact factor: 7.934

7.  Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones.

Authors:  Danielle M Stacy; Michael A Welsh; Philip N Rather; Helen E Blackwell
Journal:  ACS Chem Biol       Date:  2012-08-14       Impact factor: 5.100

Review 8.  Considerations and caveats in anti-virulence drug development.

Authors:  Damien Maura; Alicia E Ballok; Laurence G Rahme
Journal:  Curr Opin Microbiol       Date:  2016-06-16       Impact factor: 7.934

9.  Coral-Associated Bacteria as a Promising Antibiofilm Agent against Methicillin-Resistant and -Susceptible Staphylococcus aureus Biofilms.

Authors:  Shanmugaraj Gowrishankar; Nyagwencha Duncun Mosioma; Shunmugiah Karutha Pandian
Journal:  Evid Based Complement Alternat Med       Date:  2012-09-04       Impact factor: 2.629

Review 10.  Inhibition of Virulence Factors and Biofilm Formation of Acinetobacter Baumannii by Naturally-derived and Synthetic Drugs.

Authors:  Nilushi Indika Bamunuarachchi; Fazlurrahman Khan; Young-Mog Kim
Journal:  Curr Drug Targets       Date:  2021       Impact factor: 2.937
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