Synthesis and antibiofilm activity of marine natural product-based 4-thiazolidinones derivatives.

4-Thiazolidinones derivatives of marine bromopyrrole alkaloids were synthesized as potential antibiofilm compounds. Among the synthesized compounds, some showed promising antibiofilm activity. Biological data revealed that 1,3-thiazolidin-4-one derivatives are more potent antibiofilm agents compared to 1,3-thiazinan-4-ones. Antibiofilm activity of compound 4b, 4c (MIC=0.78 μg/ml) was 3-fold superior than standard vancomycin (MIC=3.125 μg/ml) while activity of compound 4d, 4f, 4g and 4h was 2-fold (MIC=1.56 μg/ml) against Staphylococcus aureus biofilm. Compound 4b-4h showed equal antibiofilm activity against Staphylococcus epidermidis compared to standard Vancomycin (MIC=3.125 μg/ml).