Literature DB >> 27334403

Alpha-synuclein modulates dopamine neurotransmission.

Brittany Butler1, Danielle Sambo1, Habibeh Khoshbouei2.   

Abstract

Alpha-synuclein is a small, highly charged protein encoded by the synuclein or SNCA gene that is predominantly expressed in central nervous system neurons. Although its physiological function remains enigmatic, alpha-synuclein is implicated in movement disorders such as Parkinson's disease, multiple system atrophy, and in neurodegenerative diseases such as Dementia with Lewy bodies. Here we have focused on reviewing the existing literature pertaining to wild-type alpha-synuclein structure, its properties, and its potential involvement in regulation of dopamine neurotransmission.
Copyright © 2016 Elsevier B.V. All rights reserved.

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Year:  2016        PMID： 27334403      PMCID： PMC5167661          DOI： 10.1016/j.jchemneu.2016.06.001

Source DB:  PubMed          Journal:  J Chem Neuroanat        ISSN： 0891-0618            Impact factor:   3.052


  135 in total

1.  Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

Authors:  F J Lee; F Liu; Z B Pristupa; H B Niznik
Journal:  FASEB J       Date:  2001-04       Impact factor: 5.191

2.  alpha-Synuclein shares physical and functional homology with 14-3-3 proteins.

Authors:  N Ostrerova; L Petrucelli; M Farrer; N Mehta; P Choi; J Hardy; B Wolozin
Journal:  J Neurosci       Date:  1999-07-15       Impact factor: 6.167

3.  Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.

Authors:  John P Anderson; Donald E Walker; Jason M Goldstein; Rian de Laat; Kelly Banducci; Russell J Caccavello; Robin Barbour; Jiping Huang; Kristin Kling; Michael Lee; Linnea Diep; Pamela S Keim; Xiaofeng Shen; Tim Chataway; Michael G Schlossmacher; Peter Seubert; Dale Schenk; Sukanto Sinha; Wei Ping Gai; Tamie J Chilcote
Journal:  J Biol Chem       Date:  2006-07-17       Impact factor: 5.157

4.  Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells.

Authors:  Xiangmin Peng; Xiangmin M Peng; Roya Tehranian; Paula Dietrich; Leonidas Stefanis; Ruth G Perez
Journal:  J Cell Sci       Date:  2005-07-19       Impact factor: 5.285

5.  Identification of two distinct synucleins from human brain.

Authors:  R Jakes; M G Spillantini; M Goedert
Journal:  FEBS Lett       Date:  1994-05-23       Impact factor: 4.124

6.  Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

Authors:  K Uéda; H Fukushima; E Masliah; Y Xia; A Iwai; M Yoshimoto; D A Otero; J Kondo; Y Ihara; T Saitoh
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

7.  Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.

Authors:  Jacqueline Burré; Manu Sharma; Theodoros Tsetsenis; Vladimir Buchman; Mark R Etherton; Thomas C Südhof
Journal:  Science       Date:  2010-08-26       Impact factor: 47.728

8.  Deletion of alpha-synuclein decreases impulsivity in mice.

Authors:  Y Peña-Oliver; V L Buchman; J W Dalley; T W Robbins; G Schumann; T L Ripley; S L King; D N Stephens
Journal:  Genes Brain Behav       Date:  2011-12-29       Impact factor: 3.449

9.  Exogenous α-synuclein decreases raft partitioning of Cav2.2 channels inducing dopamine release.

Authors:  Giuseppe Ronzitti; Giovanna Bucci; Marco Emanuele; Damiana Leo; Tatyana D Sotnikova; Liudmila V Mus; Camille H Soubrane; Mark L Dallas; Agnes Thalhammer; Lorenzo A Cingolani; Sumiko Mochida; Raul R Gainetdinov; Gary J Stephens; Evelina Chieregatti
Journal:  J Neurosci       Date:  2014-08-06       Impact factor: 6.167

10.  Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra.

Authors:  Pablo Garcia-Reitboeck; Oleg Anichtchik; Jeffrey W Dalley; Natalia Ninkina; George K Tofaris; Vladimir L Buchman; Maria Grazia Spillantini
Journal:  Exp Neurol       Date:  2013-08-08       Impact factor: 5.330
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  15 in total

1.  PET imaging of the influence of physiological and pathological α-synuclein on dopaminergic and serotonergic neurotransmission in mouse models.

Authors:  Elise Levigoureux; Caroline Bouillot; Thierry Baron; Luc Zimmer; Sophie Lancelot
Journal:  CNS Neurosci Ther       Date:  2018-05-20       Impact factor: 5.243

2.  Modification of C Terminus Provides New Insights into the Mechanism of α-Synuclein Aggregation.

Authors:  Kseniia Afitska; Anna Fucikova; Volodymyr V Shvadchak; Dmytro A Yushchenko
Journal:  Biophys J       Date:  2017-09-20       Impact factor: 4.033

Review 3.  HIV, Tat and dopamine transmission.

Authors:  Peter J Gaskill; Douglas R Miller; Joyonna Gamble-George; Hideaki Yano; Habibeh Khoshbouei
Journal:  Neurobiol Dis       Date:  2017-04-27       Impact factor: 5.996

Review 4.  Glycoconjugate journal special issue on: the glycobiology of Parkinson's disease.

Authors:  Inka Brockhausen; John Schutzbach; Jiabei Wang; Beth Fishwick; Jennifer Brockhausen
Journal:  Glycoconj J       Date:  2021-11-10       Impact factor: 2.916

Review 5.  Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review.

Authors:  Bruna Martins; Mónica Vieira; Cristina Delerue-Matos; Clara Grosso; Cristina Soares
Journal:  Mar Drugs       Date:  2022-05-28       Impact factor: 6.085

6.  Kdm6b Haploinsufficiency Causes ASD/ADHD-Like Behavioral Deficits in Mice.

Authors:  Yuen Gao; Mohammad B Aljazi; Jin He
Journal:  Front Behav Neurosci       Date:  2022-05-31       Impact factor: 3.617

7.  Lithium Improves Dopamine Neurotransmission and Increases Dopaminergic Protein Abundance in the Striatum after Traumatic Brain Injury.

Authors:  Shaun W Carlson; C Edward Dixon
Journal:  J Neurotrauma       Date:  2018-08-13       Impact factor: 5.269

8.  Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1.

Authors:  Shruti Sharma; Shalini Trivedi; Taruna Pandey; Sachin Ranjan; Mashu Trivedi; Rakesh Pandey
Journal:  Mol Neurobiol       Date:  2020-09-07       Impact factor: 5.590

9.  Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein.

Authors:  Na Li; Tessandra Stewart; Lifu Sheng; Min Shi; Eugene M Cilento; Yufeng Wu; Jau-Syong Hong; Jing Zhang
Journal:  J Neuroinflammation       Date:  2020-09-17       Impact factor: 8.322

10.  HSP90 Co-Chaperone, CacyBP/SIP, Protects α-Synuclein from Aggregation.

Authors:  Anastasiia Bohush; Anna Filipek
Journal:  Cells       Date:  2020-10-08       Impact factor: 6.600
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