Literature DB >> 23933574

Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra.

Pablo Garcia-Reitboeck1, Oleg Anichtchik, Jeffrey W Dalley, Natalia Ninkina, George K Tofaris, Vladimir L Buchman, Maria Grazia Spillantini.   

Abstract

The presynaptic protein α-synuclein is central to the pathogenesis of α-synucleinopathies. We show that the presence of endogenous mouse α-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deletion of the α-synuclein gene or C57Bl/6J mice with a targeted deletion of the α-synuclein gene. This effect of α-synuclein on dopaminergic neuron occurs during development between E10.5 and E13.5 and persists in adult life supporting the involvement of α-synuclein in the development of a subset of dopaminergic neurons.
© 2013.

Entities:  

Keywords:  Dopaminergic; Embryonic development; Parkinson's disease; Transgenic mouse; α-Synuclein

Mesh：

Substances：

Year:  2013        PMID： 23933574      PMCID： PMC4104299          DOI： 10.1016/j.expneurol.2013.07.015

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


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