| Literature DB >> 27328869 |
Takuya Suga1, Mayu Shiina1, Yukihiro Asami1,2, Masato Iwatsuki1,2, Tsuyoshi Yamamoto2, Kenichi Nonaka2, Rokuro Masuma1,2, Hidehito Matsui2, Hideaki Hanaki2, Susumu Iwamoto3, Hideyuki Onodera3, Kazuro Shiomi1,2, Satoshi Ōmura2.
Abstract
Two new compounds, designated paraphaeosphaeride D (1) and berkleasmin F (2) together with a previously known compound, berkleasmin A (3), isolated from a culture broth of the fungus Paraphaeosphaeria sp. TR-022, proved to be new circumventors of arbekacin (ABK) resistance in methicillin-resistant Staphylococcus aureus (MRSA). The structures of 1 and 2 were elucidated by spectroscopic analyses, including various NMR experiments. All compounds showed 10-100 times ABK circumvention activities using the paper disc method and reduced the MIC values of ABK against MRSA from 16 μg ml(-1) to 4 μg ml(-1) (fourfold) using the agar dilution method. These new compounds might be promising lead compounds for developing circumventors of ABK resistance in MRSA.Entities:
Mesh：
Substances：
Year: 2016 PMID： 27328869 DOI： 10.1038/ja.2016.70
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649