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Literature DB >> 16928075

Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus.

Katherine N Maloney¹, Wenshan Hao, Jun Xu, Jay Gibbons, John Hucul, Deborah Roll, Sean F Brady, Frank C Schroeder, Jon Clardy.

Abstract

Phaeosphaeride A, a nitrogen-containing bicyclic compound produced by an endophytic fungus, inhibits signaling by the transcription factor STAT3.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2006 PMID： 16928075 PMCID： PMC2518690 DOI： 10.1021/ol061556f

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

14 in total

Review 1. Endophytes: a rich source of functional metabolites.

Authors: R X Tan; W X Zou
Journal: Nat Prod Rep Date: 2001-08 Impact factor: 13.423

2. Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway .

Authors: W Lou; Z Ni; K Dyer; D J Tweardy; A C Gao
Journal: Prostate Date: 2000-02-15 Impact factor: 4.104

Review 3. Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence.

Authors: A A Leslie Gunatilaka
Journal: J Nat Prod Date: 2006-03 Impact factor: 4.050

4. Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy.

Authors: Yean Kit Lee; Crescent R Isham; Scott H Kaufman; Keith C Bible
Journal: Mol Cancer Ther Date: 2006-01 Impact factor: 6.261

5. Geographic Distribution of Endangered Species in the United States

Authors:
Journal: Science Date: 1997-01-24 Impact factor: 47.728

6. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

Authors: R Garcia; C L Yu; A Hudnall; R Catlett; K L Nelson; T Smithgall; D J Fujita; S P Ethier; R Jove
Journal: Cell Growth Differ Date: 1997-12

7. Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha.

Authors: A Pansky; P Hildebrand; E Fasler-Kan; L Baselgia; S Ketterer; C Beglinger; M H Heim
Journal: Int J Cancer Date: 2000-03-01 Impact factor: 7.396

8. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.

Authors: Guilian Niu; Kenneth L Wright; Mei Huang; Lanxi Song; Eric Haura; James Turkson; Shumin Zhang; Tianhong Wang; Dominic Sinibaldi; Domenico Coppola; Richard Heller; Lee M Ellis; James Karras; Jacqueline Bromberg; Drew Pardoll; Richard Jove; Hua Yu
Journal: Oncogene Date: 2002-03-27 Impact factor: 9.867

9. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1.

Authors: Y Shen; G Devgan; J E Darnell; J F Bromberg
Journal: Proc Natl Acad Sci U S A Date: 2001-02-06 Impact factor: 11.205

10. Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility.

Authors: Debra L Silver; Honami Naora; Jinsong Liu; Wenjun Cheng; Denise J Montell
Journal: Cancer Res Date: 2004-05-15 Impact factor: 12.701

15 in total

Review 1. Recent trends in the structural revision of natural products.

Authors: Bhuwan Khatri Chhetri; Serge Lavoie; Anne Marie Sweeney-Jones; Julia Kubanek
Journal: Nat Prod Rep Date: 2018-06-20 Impact factor: 13.423

2. Paraphaeosphaeride D and berkleasmin F, new circumventors of arbekacin resistance in MRSA, produced by Paraphaeosphaeria sp. TR-022.

Authors: Takuya Suga; Mayu Shiina; Yukihiro Asami; Masato Iwatsuki; Tsuyoshi Yamamoto; Kenichi Nonaka; Rokuro Masuma; Hidehito Matsui; Hideaki Hanaki; Susumu Iwamoto; Hideyuki Onodera; Kazuro Shiomi; Satoshi Ōmura
Journal: J Antibiot (Tokyo) Date: 2016-06-22 Impact factor: 2.649

3. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway.

Authors: Xiaomei Ren; Lei Duan; Qiang He; Zhang Zhang; Yi Zhou; Donghai Wu; Jingxuan Pan; Duanqing Pei; Ke Ding
Journal: ACS Med Chem Lett Date: 2010-09-07 Impact factor: 4.345

4. Identification of a New Series of STAT3 Inhibitors by Virtual Screening.

Authors: Kenji Matsuno; Yoshiaki Masuda; Yutaka Uehara; Hiroshi Sato; Ayumu Muroya; Osamu Takahashi; Takane Yokotagawa; Toshio Furuya; Tadashi Okawara; Masami Otsuka; Naohisa Ogo; Tadashi Ashizawa; Chie Oshita; Sachiko Tai; Hidee Ishii; Yasuto Akiyama; Akira Asai
Journal: ACS Med Chem Lett Date: 2010-07-13 Impact factor: 4.345

5. Crystal structure of natural phaeosphaeride A.

Authors: Victoria V Abzianidze; Ekaterina V Poluektova; Ksenia P Bolshakova; Taras L Panikorovskii; Alexander S Bogachenkov; Alexander O Berestetskiy
Journal: Acta Crystallogr E Crystallogr Commun Date: 2015-07-31

6. NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462.

Authors: Chun-Shun Li; Ariel M Sarotti; Peng Huang; Uyen T Dang; Julian G Hurdle; Tamara P Kondratyuk; John M Pezzuto; James Turkson; Shugeng Cao
Journal: Sci Rep Date: 2017-09-05 Impact factor: 4.379