Literature DB >> 26107089

A New Metabolite with a Unique 4-Pyranone-γ-Lactam-1,4-Thiazine Moiety from a Hawaiian-Plant Associated Fungus.

Chun-Shun Li, Yuanqing Ding1, Bao-Jun Yang, Gabriella Miklossy, Hong-Quan Yin1, Larry A Walker1, James Turkson, Shugeng Cao2.   

Abstract

An endophytic fungus Paraphaeosphaeria neglecta FT462 isolated from the Hawaiian-plant Lycopodiella cernua (L.) Pic. Serm produced one unusual compound (1, paraphaeosphaeride A) with the 4-pyranone-γ-lactam-1,4-thiazine moiety, along with two new compounds (2 and 3, paraphaeosphaerides B and C, respectively) and the known compound (4). Compounds 1-3 were characterized by NMR and MS spectroscopic analysis. The absolute configuration of the 3-position of compound 1 was determined as S by electronic circular dichroism (ECD) calculations. Compound 3 also showed STAT3 inhibition at 10 μM.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26107089     DOI： 10.1021/acs.orglett.5b01650

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  16 in total

Review 1.  Recent trends in the structural revision of natural products.

Authors:  Bhuwan Khatri Chhetri; Serge Lavoie; Anne Marie Sweeney-Jones; Julia Kubanek
Journal:  Nat Prod Rep       Date:  2018-06-20       Impact factor: 13.423

2.  Paraphaeosphaeride D and berkleasmin F, new circumventors of arbekacin resistance in MRSA, produced by Paraphaeosphaeria sp. TR-022.

Authors:  Takuya Suga; Mayu Shiina; Yukihiro Asami; Masato Iwatsuki; Tsuyoshi Yamamoto; Kenichi Nonaka; Rokuro Masuma; Hidehito Matsui; Hideaki Hanaki; Susumu Iwamoto; Hideyuki Onodera; Kazuro Shiomi; Satoshi Ōmura
Journal:  J Antibiot (Tokyo)       Date:  2016-06-22       Impact factor: 2.649

3.  Verbenanone, an octahydro-5H-chromen-5-one from a Hawaiian-Plant Associated Fungus FT431.

Authors:  Chunshun Li; Ariel M Sarotti; James Turkson; Shugeng Cao
Journal:  Tetrahedron Lett       Date:  2017-05-02       Impact factor: 2.415

4.  Tryptoquivalines W and X, two new compounds from a Hawaiian fungal strain and their biological activities.

Authors:  Kh Ahammad Uz Zaman; Zhenquan Hu; Xiaohua Wu; Shugeng Cao
Journal:  Tetrahedron Lett       Date:  2020-02-11       Impact factor: 2.415

5.  Anti-proliferative ambuic acid derivatives from Hawaiian endophytic fungus Pestalotiopsis sp. FT172.

Authors:  Chun-Shun Li; Bao-Jun Yang; James Turkson; Shugeng Cao
Journal:  Phytochemistry       Date:  2017-08       Impact factor: 4.072

6.  NF-κB inhibitory, antimicrobial and antiproliferative potentials of compounds from Hawaiian fungus Aspergillus polyporicola FS910.

Authors:  Cong Wang; K H Ahammad Uz Zaman; Ariel M Sarotti; Xiaohua Wu; Shao-Liang Zheng; Shugeng Cao
Journal:  3 Biotech       Date:  2021-07-30       Impact factor: 2.893

Review 7.  Sulfur-Containing Compounds from Endophytic Fungi: Sources, Structures and Bioactivities.

Authors:  Yaqin Fan; Zhiheng Ma; Yan Zhang; Yufei Wang; Yousong Ding; Cong Wang; Shugeng Cao
Journal:  J Fungi (Basel)       Date:  2022-06-13

8.  Hawaii natural compounds are promising to reduce ovarian cancer deaths.

Authors:  David J Fei-Zhang; Chunshun Li; Shugeng Cao
Journal:  Cancer Biol Ther       Date:  2016-05-04       Impact factor: 4.742

Review 9.  Accessing Nature's diversity through metabolic engineering and synthetic biology.

Authors:  Jason R King; Steven Edgar; Kangjian Qiao; Gregory Stephanopoulos
Journal:  F1000Res       Date:  2016-03-24

10.  NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462.

Authors:  Chun-Shun Li; Ariel M Sarotti; Peng Huang; Uyen T Dang; Julian G Hurdle; Tamara P Kondratyuk; John M Pezzuto; James Turkson; Shugeng Cao
Journal:  Sci Rep       Date:  2017-09-05       Impact factor: 4.379
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.