| Literature DB >> 24004199 |
Keiko Takata1, Masato Iwatsuki, Tsuyoshi Yamamoto, Tatsuya Shirahata, Kenichi Nonaka, Rokuro Masuma, Yoichi Hayakawa, Hideaki Hanaki, Yoshinori Kobayashi, George A Petersson, Satoshi Ōmura, Kazuro Shiomi.
Abstract
Aogacillins A and B, capable of overcoming arbekacin resistance in methicillin-resistant Staphylococcus aureus (MRSA), were isolated from a culture broth of Simplicillium sp. FKI-5985. Their structures were elucidated by NMR spectroscopic studies and ECD analyses. The aogacillins possessed a novel carbon skeleton, including a β-keto-γ-methyliden-δ-lactone ring connected to a 2-ethyl-6-methylcyclohexane ring by spiro conjugation.Entities:
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Year: 2013 PMID： 24004199 DOI： 10.1021/ol401975z
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005