Literature DB >> 27322953

Musashi-2 promotes migration and invasion in bladder cancer via activation of the JAK2/STAT3 pathway.

Chenlu Yang1,2, Weijing Zhang2, Longwang Wang1,3, Gallina Kazobinka1, Xiaomin Han1, Bin Li1, Teng Hou1,2.   

Abstract

Musashi-2 (Msi2) is considered to have a crucial role in regulating various key cellular functions. However, the clinical significance and biological role of Msi2 in bladder cancer remains unknown. We examined the expression of Msi2 in bladder cancer cell lines in 167 clinical samples and the biological role of Msi2 in bladder cancer cells. Western blotting was used to investigate the possible mechanism of Msi2-induced migration and invasion in bladder cancer. Msi2 was significantly upregulated in bladder cancer cells and tissues compared with normal bladder urothelial cells and tissues. Immunohistochemical analysis revealed high expression of Msi2 in 57 of 167 (34.1%) bladder cancer specimens. Statistical analysis showed a significant correlation of Msi2 expression with advanced clinical stage, lymph node metastasis, and poor prognosis. Overexpression and ablation of Msi2 promoted and inhibited, respectively, the migration and invasion of bladder cancer cells. Furthermore, we found that Msi2 activated the JAK2/STAT3 pathway and promoted expression of genes downstream of JAK2/STAT3 in bladder cancer. This study demonstrates that Msi2 can induce bladder cancer cell migration and invasion by activating the JAK2/STAT3 pathway, and that Msi2 may be a valuable prognostic biomarker for bladder cancer patients.

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Year:  2016        PMID： 27322953     DOI： 10.1038/labinvest.2016.71

Source DB:  PubMed          Journal:  Lab Invest        ISSN： 0023-6837            Impact factor:   5.662


  28 in total

1.  Musashi-2 promotes hepatitis Bvirus related hepatocellular carcinoma progression via the Wnt/β-catenin pathway.

Authors:  Ming-Hai Wang; Shi-Yong Qin; Shu-Guang Zhang; Guang-Xin Li; Zhen-Hai Yu; Kun Wang; Bin Wang; Mu-Jian Teng; Zhi-Hai Peng
Journal:  Am J Cancer Res       Date:  2015-02-15       Impact factor: 6.166

2.  Combination of AG490, a Jak2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway.

Authors:  Youn Hee Joung; Yoon Mi Na; Young Bum Yoo; Pramod Darvin; Nipin Sp; Dong Young Kang; Sang Yoon Kim; Hong Sup Kim; Yoon Hee Choi; Hak Kyo Lee; Kyung Do Park; Byung Wook Cho; Heui Soo Kim; Jong Hwan Park; Young Mok Yang
Journal:  Int J Oncol       Date:  2014-01-08       Impact factor: 5.650

Review 3.  Epidemiology of bladder cancer.

Authors:  Núria Malats; Francisco X Real
Journal:  Hematol Oncol Clin North Am       Date:  2015-04       Impact factor: 3.722

4.  RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.

Authors:  Shin-ichi Sakakibara; Yuki Nakamura; Tetsu Yoshida; Shinsuke Shibata; Masato Koike; Hiroshi Takano; Shuichi Ueda; Yasuo Uchiyama; Tetsuo Noda; Hideyuki Okano
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-29       Impact factor: 11.205

5.  EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22.

Authors:  An De Weer; Frank Speleman; Barbara Cauwelier; Nadine Van Roy; Nurten Yigit; Bruno Verhasselt; Barbara De Moerloose; Yves Benoit; Lucien Noens; Dominik Selleslag; Eric Lippert; Stephanie Struski; Christian Bastard; Anne De Paepe; Peter Vandenberghe; Anne Hagemeijer; Nicole Dastugue; Bruce Poppe
Journal:  Haematologica       Date:  2008-09-24       Impact factor: 9.941

Review 6.  Bladder cancer.

Authors:  Donald S Kaufman; William U Shipley; Adam S Feldman
Journal:  Lancet       Date:  2009-06-10       Impact factor: 79.321

7.  Musashi2 is required for the self-renewal and pluripotency of embryonic stem cells.

Authors:  Erin L Wuebben; Sunil K Mallanna; Jesse L Cox; Angie Rizzino
Journal:  PLoS One       Date:  2012-04-04       Impact factor: 3.240

8.  Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin.

Authors:  Yixiang Han; Aifang Ye; Yan Zhang; Zhimin Cai; Wei Wang; Lan Sun; Songfu Jiang; Jianbo Wu; Kang Yu; Shenghui Zhang
Journal:  PLoS One       Date:  2015-08-26       Impact factor: 3.240

9.  Musashi2 predicts poor prognosis and invasion in hepatocellular carcinoma by driving epithelial-mesenchymal transition.

Authors:  Lu He; Xinke Zhou; Chen Qu; Lijuan Hu; Yunqiang Tang; Qiong Zhang; Min Liang; Jian Hong
Journal:  J Cell Mol Med       Date:  2013-10-31       Impact factor: 5.310

10.  MicroRNA-196a promotes cervical cancer proliferation through the regulation of FOXO1 and p27Kip1.

Authors:  T Hou; J Ou; X Zhao; X Huang; Y Huang; Y Zhang
Journal:  Br J Cancer       Date:  2014-01-14       Impact factor: 7.640
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  24 in total

Review 1.  Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets.

Authors:  Alexander E Kudinov; John Karanicolas; Erica A Golemis; Yanis Boumber
Journal:  Clin Cancer Res       Date:  2017-01-31       Impact factor: 12.531

Review 2.  [Advances in research of Musashi2 in solid tumors].

Authors:  Y Yang; M Zhao; T Ding; C Ni; Q Zheng; X Li
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2022-03-20

3.  Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.

Authors:  Aditi Shastri; Gaurav Choudhary; Margarida Teixeira; Shanisha Gordon-Mitchell; Nandini Ramachandra; Lumie Bernard; Sanchari Bhattacharyya; Robert Lopez; Kith Pradhan; Orsolya Giricz; Goutham Ravipati; Li-Fan Wong; Sally Cole; Tushar D Bhagat; Jonathan Feld; Yosman Dhar; Matthias Bartenstein; Victor J Thiruthuvanathan; Amittha Wickrema; B Hilda Ye; David A Frank; Andrea Pellagatti; Jacqueline Boultwood; Tianyuan Zhou; Youngsoo Kim; A Robert MacLeod; P K Epling-Burnette; Minwei Ye; Patricia McCoon; Richard Woessner; Ulrich Steidl; Britta Will; Amit Verma
Journal:  J Clin Invest       Date:  2018-11-05       Impact factor: 14.808

Review 4.  Cancer the'RBP'eutics-RNA-binding proteins as therapeutic targets for cancer.

Authors:  Shakur Mohibi; Xinbin Chen; Jin Zhang
Journal:  Pharmacol Ther       Date:  2019-07-11       Impact factor: 12.310

5.  Homogeneous polyporus polysaccharide inhibits bladder cancer by polarizing macrophages to M1 subtype in tumor microenvironment.

Authors:  Wenyu Jia; Siwan Luo; Gena Lai; Shiqi Li; Shuai Huo; Meifang Li; Xing Zeng
Journal:  BMC Complement Med Ther       Date:  2021-05-25

6.  Tanshinone IIA Inhibits Epithelial-Mesenchymal Transition in Bladder Cancer Cells via Modulation of STAT3-CCL2 Signaling.

Authors:  Sung-Ying Huang; Shu-Fang Chang; Kuan-Fu Liao; Sheng-Chun Chiu
Journal:  Int J Mol Sci       Date:  2017-07-25       Impact factor: 5.923

7.  Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression.

Authors:  Leonid Kharin; Igor Bychkov; Nikolay Karnaukhov; Mark Voloshin; Rushaniya Fazliyeva; Alexander Deneka; Elena Frantsiyants; Oleg Kit; Erica Golemis; Yanis Boumber
Journal:  PLoS One       Date:  2021-07-08       Impact factor: 3.240

8.  Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation.

Authors:  Peixin Dong; Ying Xiong; Sharon J B Hanley; Junming Yue; Hidemichi Watari
Journal:  J Exp Clin Cancer Res       Date:  2017-10-26

9.  CLCA4 inhibits bladder cancer cell proliferation, migration, and invasion by suppressing the PI3K/AKT pathway.

Authors:  Teng Hou; Lijie Zhou; Longwang Wang; Gallina Kazobinka; Xiaoping Zhang; Zhaohui Chen
Journal:  Oncotarget       Date:  2017-10-09

10.  USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway.

Authors:  Haiqing He; Lu Yi; Bin Zhang; Bin Yan; Ming Xiao; Jiannan Ren; Dong Zi; Liang Zhu; Zhaohui Zhong; Xiaokun Zhao; Xin Jin; Wei Xiong
Journal:  Int J Biol Sci       Date:  2021-06-11       Impact factor: 6.580
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