Literature DB >> 31302171

Cancer the'RBP'eutics-RNA-binding proteins as therapeutic targets for cancer.

Shakur Mohibi1, Xinbin Chen1, Jin Zhang2.   

Abstract

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Aptamer; Cancer therapeutics; Peptide; RNA-binding domains; RNA-binding proteins; Small molecules; siRNA

Mesh：

Substances：

Year:  2019        PMID： 31302171      PMCID： PMC6848768          DOI： 10.1016/j.pharmthera.2019.07.001

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  539 in total

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Authors:  C Braeutigam; L Rago; A Rolke; L Waldmeier; G Christofori; J Winter
Journal:  Oncogene       Date:  2013-02-25       Impact factor: 9.867

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Journal:  Nat Genet       Date:  2015-07-20       Impact factor: 38.330

5.  Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.

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Journal:  Cancer Res       Date:  2010-01-12       Impact factor: 12.701

6.  A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.

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7.  Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.

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8.  Suppression of Poly(rC)-Binding Protein 4 (PCBP4) reduced cisplatin resistance in human maxillary cancer cells.

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Journal:  Sci Rep       Date:  2015-07-21       Impact factor: 4.379

9.  The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer.

Authors:  Phillip M Shelton; Angeles Duran; Yuki Nakanishi; Miguel Reina-Campos; Hiroaki Kasashima; Victoria Llado; Li Ma; Alex Campos; Damián García-Olmo; Mariano García-Arranz; Dolores C García-Olmo; Susana Olmedillas-López; Javier F Caceres; Maria T Diaz-Meco; Jorge Moscat
Journal:  Cell Rep       Date:  2018-04-24       Impact factor: 9.423

Review 10.  Targeting RNA: A Transformative Therapeutic Strategy.

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Journal:  Clin Transl Sci       Date:  2019-02-27       Impact factor: 4.689
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  45 in total

1.  STAT1 mediated long non-coding RNA LINC00504 influences radio-sensitivity of breast cancer via binding to TAF15 and stabilizing CPEB2 expression.

Authors:  Jinchun Feng; Yan Li; Liping Zhu; Qian Zhao; Dan Li; Yuxiang Li; Tao Wu
Journal:  Cancer Biol Ther       Date:  2021-12-15       Impact factor: 4.742

Review 2.  Drug delivery approaches for HuR-targeted therapy for lung cancer.

Authors:  Rajeswari Raguraman; Santny Shanmugarama; Meghna Mehta; Jo Elle Peterson; Yan D Zhao; Anupama Munshi; Rajagopal Ramesh
Journal:  Adv Drug Deliv Rev       Date:  2021-11-22       Impact factor: 15.470

Review 3.  Delivery of CRISPR-Cas9 system for screening and editing RNA binding proteins in cancer.

Authors:  Jingyue Yan; Diana D Kang; Gillian Turnbull; Yizhou Dong
Journal:  Adv Drug Deliv Rev       Date:  2021-11-09       Impact factor: 15.470

4.  The RNA helicase DDX5 supports mitochondrial function in small cell lung cancer.

Authors:  Zheng Xing; Matthew P Russon; Sagar M Utturkar; Elizabeth J Tran
Journal:  J Biol Chem       Date:  2020-05-06       Impact factor: 5.157

Review 5.  To protect and modify double-stranded RNA - the critical roles of ADARs in development, immunity and oncogenesis.

Authors:  Emily A Erdmann; Ananya Mahapatra; Priyanka Mukherjee; Boyoon Yang; Heather A Hundley
Journal:  Crit Rev Biochem Mol Biol       Date:  2020-12-27       Impact factor: 8.250

Review 6.  RNA-Binding Proteins Hold Key Roles in Function, Dysfunction, and Disease.

Authors:  Sophia Kelaini; Celine Chan; Victoria A Cornelius; Andriana Margariti
Journal:  Biology (Basel)       Date:  2021-04-24

7.  Mice Deficient in the RNA-Binding Protein Zfp871 Are Prone to Early Death and Steatohepatitis in Part through the p53-Mdm2 Axis.

Authors:  Shakur Mohibi; Jin Zhang; Mingyi Chen; Xinbin Chen
Journal:  Mol Cancer Res       Date:  2021-07-13       Impact factor: 5.852

Review 8.  Oncogenic Potential of the Dual-Function Protein MEX3A.

Authors:  Marcell Lederer; Simon Müller; Markus Glaß; Nadine Bley; Christian Ihling; Andrea Sinz; Stefan Hüttelmaier
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Review 9.  Musashi-1-A Stemness RBP for Cancer Therapy?

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Journal:  Biology (Basel)       Date:  2021-05-05

10.  Editorial: Perturbation of RNA Binding Protein Regulation in Cancer.

Authors:  Yongsheng Li; Juan Xu
Journal:  Front Genet       Date:  2021-06-24       Impact factor: 4.599
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