Elena J Ladas1, Manuela Orjuela2, Kristen Stevenson3, Peter D Cole4, Meiko Lin5, Uma H Athale6, Luis A Clavell7, Jean-Marie Leclerc8, Bruno Michon9, Marshall A Schorin10, Jennifer Greene Welch11, Barbara L Asselin12, Stephen E Sallan3, Lewis B Silverman3, Kara M Kelly13. 1. Division of Pediatric Hematology/Oncology/Stem Cell Transplant, Columbia University Medical Center, New York, New York, USA; Institute of Human Nutrition, Columbia University, New York, New York, USA. Electronic address: ejd14@cumc.columbia.edu. 2. Division of Pediatric Hematology/Oncology/Stem Cell Transplant, Columbia University Medical Center, New York, New York, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, New York, USA. 3. Dana-Farber Cancer Institute/Boston Children's Hospital, Boston, Massachusetts, USA. 4. Albert Einstein College of Medicine, Bronx, New York, USA. 5. Teachers College, Columbia University, New York, New York, USA. 6. Division of Hematology/Oncology, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, Ontario, Canada. 7. San Jorge Children's Hospital, San Juan, Puerto Rico. 8. Hematology-Oncology Division, Charles Bruneau Cancer Center, Sainte-Justine University Hospital, University of Montreal, Montreal, Quebec, Canada. 9. Centre Hospitalier Universitaire de Quebec, Sainte-Foy, Quebec, Canada. 10. Inova Children's Hospital, Falls Church, Virginia, USA. 11. Division of Pediatric Hematology/Oncology, Hasbro Children's Hospital, Brown University, Providence, RI, USA. 12. Department of Pediatrics, University of Rochester School of Medicine, Golisano Children's Hospital at University of Rochester Medical Center, Rochester, New York, USA. 13. Division of Pediatric Hematology/Oncology/Stem Cell Transplant, Columbia University Medical Center, New York, New York, USA.
Abstract
OBJECTIVE: Children with acute lymphoblastic leukemia (ALL) are at elevated risk for nutrition-related morbidity both during and after therapy. We present the demographic characteristics and nutrient intake at study entry of a prospective cohort in which evaluating dietary intake in children diagnosed with ALL was investigated. METHODS: Dietary intake data were collected for participants enrolled on the Dana-Farber Cancer Institute ALL Consortium Protocol. Dietary intake was assessed with a food frequency questionnaire and was compared with the dietary reference intake by ALL risk group (standard and high risk). RESULTS: Dietary intake data were collected from 81% of participants (n = 640). We found that 27% of participants were overweight/obese. Intake of total calories and other nutrients exceeded the dietary reference intake in up to 79% of children. This was evident in both risk groups and was pronounced among younger children. For micronutrients, dietary intake of calcium, vitamin D (females only), and zinc differed significantly between patients with standard-risk and those with high-risk ALL. CONCLUSIONS: This study was successful in collecting dietary intake data at the time of cancer diagnosis in a multicenter setting in a pediatric population at high-risk for nutrition-related morbidity. We identified "at-risk" dietary intakes, which vary by sex and ALL risk group; such patients may benefit from future dietary interventions.
OBJECTIVE:Children with acute lymphoblastic leukemia (ALL) are at elevated risk for nutrition-related morbidity both during and after therapy. We present the demographic characteristics and nutrient intake at study entry of a prospective cohort in which evaluating dietary intake in children diagnosed with ALL was investigated. METHODS: Dietary intake data were collected for participants enrolled on the Dana-Farber Cancer Institute ALL Consortium Protocol. Dietary intake was assessed with a food frequency questionnaire and was compared with the dietary reference intake by ALL risk group (standard and high risk). RESULTS: Dietary intake data were collected from 81% of participants (n = 640). We found that 27% of participants were overweight/obese. Intake of total calories and other nutrients exceeded the dietary reference intake in up to 79% of children. This was evident in both risk groups and was pronounced among younger children. For micronutrients, dietary intake of calcium, vitamin D (females only), and zinc differed significantly between patients with standard-risk and those with high-risk ALL. CONCLUSIONS: This study was successful in collecting dietary intake data at the time of cancer diagnosis in a multicenter setting in a pediatric population at high-risk for nutrition-related morbidity. We identified "at-risk" dietary intakes, which vary by sex and ALL risk group; such patients may benefit from future dietary interventions.
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