Literature DB >> 27313038

Translational control by 5'-untranslated regions of eukaryotic mRNAs.

Alan G Hinnebusch1, Ivaylo P Ivanov1, Nahum Sonenberg2.   

Abstract

The eukaryotic 5' untranslated region (UTR) is critical for ribosome recruitment to the messenger RNA (mRNA) and start codon choice and plays a major role in the control of translation efficiency and shaping the cellular proteome. The ribosomal initiation complex is assembled on the mRNA via a cap-dependent or cap-independent mechanism. We describe various mechanisms controlling ribosome scanning and initiation codon selection by 5' upstream open reading frames, translation initiation factors, and primary and secondary structures of the 5'UTR, including particular sequence motifs. We also discuss translational control via phosphorylation of eukaryotic initiation factor 2, which is implicated in learning and memory, neurodegenerative diseases, and cancer.
Copyright © 2016, American Association for the Advancement of Science.

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Year:  2016        PMID： 27313038      PMCID： PMC7422601          DOI： 10.1126/science.aad9868

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  59 in total

1.  Cap-independent translation is required for starvation-induced differentiation in yeast.

Authors:  Wendy V Gilbert; Kaihong Zhou; Tamira K Butler; Jennifer A Doudna
Journal:  Science       Date:  2007-08-31       Impact factor: 47.728

Review 2.  Viral IRES RNA structures and ribosome interactions.

Authors:  Jeffrey S Kieft
Journal:  Trends Biochem Sci       Date:  2008-05-28       Impact factor: 13.807

3.  DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs.

Authors:  Ricardo Soto-Rifo; Paulina S Rubilar; Taran Limousin; Sylvain de Breyne; Didier Décimo; Théophile Ohlmann
Journal:  EMBO J       Date:  2012-08-07       Impact factor: 11.598

4.  Development and characterization of a reconstituted yeast translation initiation system.

Authors:  Mikkel A Algire; David Maag; Peter Savio; Michael G Acker; Salvador Z Tarun; Alan B Sachs; Katsura Asano; Klaus H Nielsen; Deanne S Olsen; Lon Phan; Alan G Hinnebusch; Jon R Lorsch
Journal:  RNA       Date:  2002-03       Impact factor: 4.942

5.  Multiple mechanisms of reinitiation on bicistronic calicivirus mRNAs.

Authors:  Alexandra Zinoviev; Christopher U T Hellen; Tatyana V Pestova
Journal:  Mol Cell       Date:  2015-03-19       Impact factor: 17.970

6.  Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2.

Authors:  Mauro Costa-Mattioli; Delphine Gobert; Heather Harding; Barbara Herdy; Mounia Azzi; Martin Bruno; Michael Bidinosti; Cyrinne Ben Mamou; Edwige Marcinkiewicz; Madoka Yoshida; Hiroaki Imataka; A Claudio Cuello; Nabil Seidah; Wayne Sossin; Jean-Claude Lacaille; David Ron; Karim Nader; Nahum Sonenberg
Journal:  Nature       Date:  2005-08-25       Impact factor: 49.962

Review 7.  The current status of vertebrate cellular mRNA IRESs.

Authors:  Richard J Jackson
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-02-01       Impact factor: 10.005

8.  Roles for transcript leaders in translation and mRNA decay revealed by transcript leader sequencing.

Authors:  Joshua A Arribere; Wendy V Gilbert
Journal:  Genome Res       Date:  2013-04-11       Impact factor: 9.043

9.  DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth.

Authors:  Katrin Strassburger; Philipp Christoph Janiesch; Sibylle Schleich; Tatyana Koledachkina; Katharine K Miller; Katharina Haneke; Yong-Sheng Cheng; Katrin Kuechler; Georg Stoecklin; Kent E Duncan; Aurelio A Teleman
Journal:  Nature       Date:  2014-07-06       Impact factor: 49.962

10.  nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.

Authors:  Valentina Gandin; Laia Masvidal; Laura Hulea; Simon-Pierre Gravel; Marie Cargnello; Shannon McLaughlan; Yutian Cai; Preetika Balanathan; Masahiro Morita; Arjuna Rajakumar; Luc Furic; Michael Pollak; John A Porco; Julie St-Pierre; Jerry Pelletier; Ola Larsson; Ivan Topisirovic
Journal:  Genome Res       Date:  2016-03-16       Impact factor: 9.043
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  339 in total

Review 1.  The Untranslated Regions of mRNAs in Cancer.

Authors:  Samantha L Schuster; Andrew C Hsieh
Journal:  Trends Cancer       Date:  2019-03-22

2.  New twists on long noncoding RNAs: from mobile elements to motile cancer cells.

Authors:  Tuan M Nguyen; Sumayya Alchalabi; Adewunmi Oluwatoyosi; Ali S Ropri; Jason I Herschkowitz; Jeffrey M Rosen
Journal:  RNA Biol       Date:  2020-06-10       Impact factor: 4.652

Review 3.  New pathologic mechanisms in nucleotide repeat expansion disorders.

Authors:  C M Rodriguez; P K Todd
Journal:  Neurobiol Dis       Date:  2019-06-21       Impact factor: 5.996

4.  A novel thyroid hormone receptor isoform, TRβ2-46, promotes SKP2 expression and retinoblastoma cell proliferation.

Authors:  Zhengke Li; Dong-Lai Qi; Hardeep P Singh; Yue Zou; Binghui Shen; David Cobrinik
Journal:  J Biol Chem       Date:  2019-01-14       Impact factor: 5.157

5.  Boron-Dependent Translational Suppression of the Borate Exporter BOR1 Contributes to the Avoidance of Boron Toxicity.

Authors:  Izumi Aibara; Tatsuya Hirai; Koji Kasai; Junpei Takano; Hitoshi Onouchi; Satoshi Naito; Toru Fujiwara; Kyoko Miwa
Journal:  Plant Physiol       Date:  2018-05-04       Impact factor: 8.340

6.  Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

Authors:  Rajiv K Khajuria; Mathias Munschauer; Jacob C Ulirsch; Claudia Fiorini; Leif S Ludwig; Sean K McFarland; Nour J Abdulhay; Harrison Specht; Hasmik Keshishian; D R Mani; Marko Jovanovic; Steven R Ellis; Charles P Fulco; Jesse M Engreitz; Sabina Schütz; John Lian; Karen W Gripp; Olga K Weinberg; Geraldine S Pinkus; Lee Gehrke; Aviv Regev; Eric S Lander; Hanna T Gazda; Winston Y Lee; Vikram G Panse; Steven A Carr; Vijay G Sankaran
Journal:  Cell       Date:  2018-03-15       Impact factor: 41.582

Review 7.  The Growing Toolbox for Protein Synthesis Studies.

Authors:  Shintaro Iwasaki; Nicholas T Ingolia
Journal:  Trends Biochem Sci       Date:  2017-05-28       Impact factor: 13.807

8.  eIF2α phosphorylation controls thermal nociception.

Authors:  Arkady Khoutorsky; Robert E Sorge; Masha Prager-Khoutorsky; Sophie Anne Pawlowski; Geraldine Longo; Seyed Mehdi Jafarnejad; Soroush Tahmasebi; Loren J Martin; Mark H Pitcher; Christos G Gkogkas; Reza Sharif-Naeini; Alfredo Ribeiro-da-Silva; Charles W Bourque; Fernando Cervero; Jeffrey S Mogil; Nahum Sonenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-03       Impact factor: 11.205

Review 9.  A helicase links upstream ORFs and RNA structure.

Authors:  Eckhard Jankowsky; Ulf-Peter Guenther
Journal:  Curr Genet       Date:  2018-11-27       Impact factor: 3.886

10.  mountainClimber Identifies Alternative Transcription Start and Polyadenylation Sites in RNA-Seq.

Authors:  Ashley A Cass; Xinshu Xiao
Journal:  Cell Syst       Date:  2019-09-18       Impact factor: 10.304
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