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Literature DB >> 32522127

New twists on long noncoding RNAs: from mobile elements to motile cancer cells.

Tuan M Nguyen^1,2, Sumayya Alchalabi³, Adewunmi Oluwatoyosi⁴, Ali S Ropri³, Jason I Herschkowitz³, Jeffrey M Rosen⁴.

Abstract

The purpose of this review is to highlight several areas of lncRNA biology and cancer that we hope will provide some new insights for future research. These include the relationship of lncRNAs and the epithelial to mesenchymal transition (EMT) with a focus on transcriptional and alternative splicing mechanisms and mRNA stability through miRNAs. In addition, we highlight the potential role of enhancer e-lncRNAs, the importance of transposable elements in lncRNA biology, and finally the emerging area of using antisense oligonucleotides (ASOs) and small molecules to target lncRNAs and their therapeutic implications.

Entities: Chemical Disease

Keywords: EMT; lncRNAs; transposable elements

Year: 2020 PMID： 32522127 PMCID： PMC7567495 DOI： 10.1080/15476286.2020.1760535

Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652

175 in total

1. 5'-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA.

Authors: C M Wei; A Gershowitz; B Moss
Journal: Biochemistry Date: 1976-01-27 Impact factor: 3.162

2. Targeting RNA with Small Molecules To Capture Opportunities at the Intersection of Chemistry, Biology, and Medicine.

Authors: Matthew D Disney
Journal: J Am Chem Soc Date: 2019-04-19 Impact factor: 15.419

3. lincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6.

Authors: Gabriel Eades; Benjamin Wolfson; Yongshu Zhang; Qinglin Li; Yuan Yao; Qun Zhou
Journal: Mol Cancer Res Date: 2014-09-24 Impact factor: 5.852

4. Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland.

Authors: M R Ginger; M F Gonzalez-Rimbau; J P Gay; J M Rosen
Journal: Mol Endocrinol Date: 2001-11

5. Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription.

Authors: Shi-Jiang Deng; Heng-Yu Chen; Zeng Ye; Shi-Chang Deng; Shuai Zhu; Zhu Zeng; Chi He; Ming-Liang Liu; Kang Huang; Jian-Xin Zhong; Feng-Yu Xu; Qiang Li; Yang Liu; Chun-You Wang; Gang Zhao
Journal: Oncogene Date: 2018-07-03 Impact factor: 9.867

6. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression.

Authors: Ahmad M Khalil; Mitchell Guttman; Maite Huarte; Manuel Garber; Arjun Raj; Dianali Rivea Morales; Kelly Thomas; Aviva Presser; Bradley E Bernstein; Alexander van Oudenaarden; Aviv Regev; Eric S Lander; John L Rinn
Journal: Proc Natl Acad Sci U S A Date: 2009-07-01 Impact factor: 11.205

7. Comprehensive mapping of long-range interactions reveals folding principles of the human genome.

Authors: Erez Lieberman-Aiden; Nynke L van Berkum; Louise Williams; Maxim Imakaev; Tobias Ragoczy; Agnes Telling; Ido Amit; Bryan R Lajoie; Peter J Sabo; Michael O Dorschner; Richard Sandstrom; Bradley Bernstein; M A Bender; Mark Groudine; Andreas Gnirke; John Stamatoyannopoulos; Leonid A Mirny; Eric S Lander; Job Dekker
Journal: Science Date: 2009-10-09 Impact factor: 47.728

8. AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer.

Authors: David Hong; Razelle Kurzrock; Youngsoo Kim; Richard Woessner; Anas Younes; John Nemunaitis; Nathan Fowler; Tianyuan Zhou; Joanna Schmidt; Minji Jo; Samantha J Lee; Mason Yamashita; Steven G Hughes; Luis Fayad; Sarina Piha-Paul; Murali V P Nadella; Morvarid Mohseni; Deborah Lawson; Corinne Reimer; David C Blakey; Xiaokun Xiao; Jeff Hsu; Alexey Revenko; Brett P Monia; A Robert MacLeod
Journal: Sci Transl Med Date: 2015-11-18 Impact factor: 17.956

New twists on long noncoding RNAs: from mobile elements to motile cancer cells.

1. 5'-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA.

2. Targeting RNA with Small Molecules To Capture Opportunities at the Intersection of Chemistry, Biology, and Medicine.

3. lincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6.

4. Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland.

5. Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription.

6. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression.

7. Comprehensive mapping of long-range interactions reveals folding principles of the human genome.

8. AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer.

9. The More the Merrier-Complexity in Long Non-Coding RNA Loci.

10. Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.

1. Bioinformatics Approaches for Determining the Functional Impact of Repetitive Elements on Non-coding RNAs.

2. Early-life undernutrition induces enhancer RNA remodeling in mice liver.

Review 3. Mechanisms of non-coding RNA-modulated alternative splicing in cancer.