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Literature DB >> 27308576

To break or not to break - context matters.

Abstract

Oncogene expression can lead to replication stress and genome instability. Recently, we identified oncogene-induced fragile sites (FSs) and revealed that the landscape of recurrent fragility in the same cell type is dynamic. This implies an additional level of complexity in the molecular basis of recurrent fragility in cancer.

Entities: Disease

Keywords: Cancer breakage; fragile sites; genome instability; oncogene expression; recurrent fragility; replication stress

Year: 2015 PMID： 27308576 PMCID： PMC4845246 DOI： 10.1080/23723556.2015.1072657

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

Review 1. The complex basis underlying common fragile site instability in cancer.

Authors: Efrat Ozeri-Galai; Assaf C Bester; Batsheva Kerem
Journal: Trends Genet Date: 2012-03-31 Impact factor: 11.639

2. Oncogenes create a unique landscape of fragile sites.

Authors: Karin Miron; Tamar Golan-Lev; Raz Dvir; Eyal Ben-David; Batsheva Kerem
Journal: Nat Commun Date: 2015-05-11 Impact factor: 14.919

3. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication.

Authors: Raffaella Di Micco; Marzia Fumagalli; Angelo Cicalese; Sara Piccinin; Patrizia Gasparini; Chiara Luise; Catherine Schurra; Massimiliano Garre'; Paolo Giovanni Nuciforo; Aaron Bensimon; Roberta Maestro; Pier Giuseppe Pelicci; Fabrizio d'Adda di Fagagna
Journal: Nature Date: 2006-11-30 Impact factor: 49.962

4. Cancer chromosome breakpoints and common fragile sites induced by aphidicolin.

Authors: F Hecht; T W Glover
Journal: Cancer Genet Cytogenet Date: 1984-10

5. Cyclin E deregulation promotes loss of specific genomic regions.

Authors: Leonardo K Teixeira; Xianlong Wang; Yongjiang Li; Susanna Ekholm-Reed; Xiaohua Wu; Pei Wang; Steven I Reed
Journal: Curr Biol Date: 2015-05-07 Impact factor: 10.834

6. Nucleotide deficiency promotes genomic instability in early stages of cancer development.

Authors: Assaf C Bester; Maayan Roniger; Yifat S Oren; Michael M Im; Dan Sarni; Malka Chaoat; Aaron Bensimon; Gideon Zamir; Donna S Shewach; Batsheva Kerem
Journal: Cell Date: 2011-04-29 Impact factor: 41.582

7. Signatures of mutation and selection in the cancer genome.

Authors: Graham R Bignell; Chris D Greenman; Helen Davies; Adam P Butler; Sarah Edkins; Jenny M Andrews; Gemma Buck; Lina Chen; David Beare; Calli Latimer; Sara Widaa; Jonathon Hinton; Ciara Fahey; Beiyuan Fu; Sajani Swamy; Gillian L Dalgliesh; Bin T Teh; Panos Deloukas; Fengtang Yang; Peter J Campbell; P Andrew Futreal; Michael R Stratton
Journal: Nature Date: 2010-02-18 Impact factor: 49.962

8. Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

Authors: Benoît Le Tallec; Gaël Armel Millot; Marion Esther Blin; Olivier Brison; Bernard Dutrillaux; Michelle Debatisse
Journal: Cell Rep Date: 2013-08-01 Impact factor: 9.423

9. Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study.

Authors: P K Tsantoulis; A Kotsinas; P P Sfikakis; K Evangelou; M Sideridou; B Levy; L Mo; C Kittas; X-R Wu; A G Papavassiliou; V G Gorgoulis
Journal: Oncogene Date: 2007-12-17 Impact factor: 9.867

10. Large transcription units unify copy number variants and common fragile sites arising under replication stress.

Authors: Thomas E Wilson; Martin F Arlt; So Hae Park; Sountharia Rajendran; Michelle Paulsen; Mats Ljungman; Thomas W Glover
Journal: Genome Res Date: 2014-11-04 Impact factor: 9.043

10 in total

1 in total

Review 1. Rescue from replication stress during mitosis.

Authors: Michalis Fragkos; Valeria Naim
Journal: Cell Cycle Date: 2017-02-06 Impact factor: 4.534

1 in total