Literature DB >> 27250769

The Epigenetic Pathways to Ribosomal DNA Silencing.

Rakesh Srivastava1, Rashmi Srivastava1, Seong Hoon Ahn2.   

Abstract

Heterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA (rDNA) heterochromatin, epigenetic states contribute to gene silencing and genome stability, which are required for proper chromosome segregation and a normal life span. Here, we focus on recent advances in the epigenetic regulation of rDNA silencing in Saccharomyces cerevisiae and in mammals, including regulation by several histone modifications and several protein components associated with the inner nuclear membrane within the nucleolus. Finally, we discuss the perturbations of rDNA epigenetic pathways in regulating cellular aging and in causing various types of diseases.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27250769      PMCID： PMC4981667          DOI： 10.1128/MMBR.00005-16

Source DB:  PubMed          Journal:  Microbiol Mol Biol Rev        ISSN： 1092-2172            Impact factor:   11.056


  220 in total

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2.  Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing.

Authors:  N C Tolga Emre; Kristin Ingvarsdottir; Anastasia Wyce; Adam Wood; Nevan J Krogan; Karl W Henry; Keqin Li; Ronen Marmorstein; Jack F Greenblatt; Ali Shilatifard; Shelley L Berger
Journal:  Mol Cell       Date:  2005-02-18       Impact factor: 17.970

3.  The CKH2/PKL chromatin remodeling factor negatively regulates cytokinin responses in Arabidopsis calli.

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Journal:  Plant Cell Physiol       Date:  2011-02-25       Impact factor: 4.927

4.  Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.

Authors:  S Kim; A Benguria; C Y Lai; S M Jazwinski
Journal:  Mol Biol Cell       Date:  1999-10       Impact factor: 4.138

5.  Cdc14 phosphatase induces rDNA condensation and resolves cohesin-independent cohesion during budding yeast anaphase.

Authors:  Matt Sullivan; Toru Higuchi; Vittorio L Katis; Frank Uhlmann
Journal:  Cell       Date:  2004-05-14       Impact factor: 41.582

6.  The minimal ribosomal RNA gene promoter of Arabidopsis thaliana includes a critical element at the transcription initiation site.

Authors:  J H Doelling; C S Pikaard
Journal:  Plant J       Date:  1995-11       Impact factor: 6.417

7.  Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a.

Authors:  Xuejun Yuan; Weijun Feng; Axel Imhof; Ingrid Grummt; Yonggang Zhou
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8.  Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

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Journal:  Cancer Cell       Date:  2008-10-07       Impact factor: 31.743

9.  Sir2p suppresses recombination of replication forks stalled at the replication fork barrier of ribosomal DNA in Saccharomyces cerevisiae.

Authors:  Alberto Benguría; Pablo Hernández; Dora B Krimer; Jorge B Schvartzman
Journal:  Nucleic Acids Res       Date:  2003-02-01       Impact factor: 16.971

10.  Interplay among Gcn5, Sch9 and mitochondria during chronological aging of wine yeast is dependent on growth conditions.

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Journal:  PLoS One       Date:  2015-02-06       Impact factor: 3.240
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  24 in total

Review 1.  Pif1 family DNA helicases: A helpmate to RNase H?

Authors:  Thomas J Pohl; Virginia A Zakian
Journal:  DNA Repair (Amst)       Date:  2019-06-17

2.  Existence, Transition, and Propagation of Intermediate Silencing States in Ribosomal DNA.

Authors:  Fan Zou; Manyu Du; Hengye Chen; Lu Bai
Journal:  Mol Cell Biol       Date:  2019-11-12       Impact factor: 4.272

Review 3.  Yeast HMO1: Linker Histone Reinvented.

Authors:  Arvind Panday; Anne Grove
Journal:  Microbiol Mol Biol Rev       Date:  2016-11-30       Impact factor: 11.056

Review 4.  Mechanisms of rDNA Copy Number Maintenance.

Authors:  Jonathan O Nelson; George J Watase; Natalie Warsinger-Pepe; Yukiko M Yamashita
Journal:  Trends Genet       Date:  2019-08-05       Impact factor: 11.639

5.  Analysis of Human Mitochondrial DNA Content by Southern Blotting and Nonradioactive Probe Hybridization.

Authors:  Joel H Wheeler; Carolyn K J Young; Matthew J Young
Journal:  Curr Protoc Toxicol       Date:  2019-04-14

6.  Spreading-dependent or independent Sir2-mediated gene silencing in budding yeast.

Authors:  Soojin Yeom; Junsoo Oh; Jung-Shin Lee
Journal:  Genes Genomics       Date:  2022-01-16       Impact factor: 1.839

Review 7.  Establishment and Maintenance of Open Ribosomal RNA Gene Chromatin States in Eukaryotes.

Authors:  Christopher Schächner; Philipp E Merkl; Michael Pilsl; Katrin Schwank; Kristin Hergert; Sebastian Kruse; Philipp Milkereit; Herbert Tschochner; Joachim Griesenbeck
Journal:  Methods Mol Biol       Date:  2022

Review 8.  G-Quadruplex Assembly by Ribosomal DNA: Emerging Roles in Disease Pathogenesis and Cancer Biology.

Authors:  Arindam Datta; Kevin J Pollock; Karen A Kormuth; Robert M Brosh
Journal:  Cytogenet Genome Res       Date:  2021-09-01       Impact factor: 1.941

9.  Proteasome Control of [URE3] Prion Propagation by Degradation of Anti-Prion Proteins Cur1 and Btn2 in Saccharomyces cerevisiae.

Authors:  Herman K Edskes; Emily E Stroobant; Morgan P DeWilde; Evgeny E Bezsonov; Reed B Wickner
Journal:  Genetics       Date:  2021-05-17       Impact factor: 4.562

Review 10.  Getting there: understanding the chromosomal recruitment of the AAA+ ATPase Pch2/TRIP13 during meiosis.

Authors:  Richard Cardoso da Silva; Gerben Vader
Journal:  Curr Genet       Date:  2021-03-12       Impact factor: 3.886
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