| Literature DB >> 2722671 |
W M Maiese1, M P Lechevalier, H A Lechevalier, J Korshalla, N Kuck, A Fantini, M J Wildey, J Thomas, M Greenstein.
Abstract
A novel family of antitumor antibiotics, the calicheamicins, were isolated from the fermentation broth of Micromonospora echinospora subsp. calichensis. These antibiotics exhibited significant activity against Gram-positive and Gram-negative bacteria in vitro. Calicheamicin gamma 1I demonstrated antitumor activity against P388 leukemia and B16 melanoma in vivo.Entities:
Mesh：
Substances：
Year: 1989 PMID： 2722671 DOI： 10.7164/antibiotics.42.558
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649