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Literature DB >> 1938969

Isolation of mutants blocked in calicheamicin biosynthesis.

Abstract

Blocked mutants of Micromonospora echinospora defective in the production of the potent antitumor agent calicheamicin are described. Analysis of intermediates produced by blocked mutants indicates a branched biosynthetic pathway. Mutants that produced some, but not all, calicheamicin forms are also described.

Entities: Chemical Species

Mesh：

Substances：

Year: 1991 PMID： 1938969 PMCID： PMC212544 DOI： 10.1128/jb.173.23.7716-7718.1991

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

9 in total

Review 1. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis.

Authors: D A Hopwood; D H Sherman
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Review 2. Streptomyces cloning: useful recombinant DNA systems and a summation of cloned genes.

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Review 3. Genetics of Streptomyces fradiae and tylosin biosynthesis.

Authors: R H Baltz; E T Seno
Journal: Annu Rev Microbiol Date: 1988 Impact factor: 15.500

4. Temporally regulated tandem promoters in Micromonospora echinospora.

Authors: E Z Baum; S F Love; D M Rothstein
Journal: J Bacteriol Date: 1988-01 Impact factor: 3.490

Review 5. Mutants blocked in antibiotic synthesis.

Authors: S W Queener; O K Sebek; C Vézina
Journal: Annu Rev Microbiol Date: 1978 Impact factor: 15.500

6. Biochemical prophage induction assay: a rapid test for antitumor agents that interact with DNA.

Authors: R K Elespuru; R J White
Journal: Cancer Res Date: 1983-06 Impact factor: 12.701

7. Calicheamicin gamma 1I: an antitumor antibiotic that cleaves double-stranded DNA site specifically.

Authors: N Zein; A M Sinha; W J McGahren; G A Ellestad
Journal: Science Date: 1988-05-27 Impact factor: 47.728

8. Calicheamicins, a novel family of antitumor antibiotics: taxonomy, fermentation and biological properties.

Authors: W M Maiese; M P Lechevalier; H A Lechevalier; J Korshalla; N Kuck; A Fantini; M J Wildey; J Thomas; M Greenstein
Journal: J Antibiot (Tokyo) Date: 1989-04 Impact factor: 2.649

9. Calicheamicins, a novel family of antitumor antibiotics. 3. Isolation, purification and characterization of calicheamicins beta 1Br, gamma 1Br, alpha 2I, alpha 3I, beta 1I, gamma 1I and delta 1I.

Authors: M D Lee; J K Manning; D R Williams; N A Kuck; R T Testa; D B Borders
Journal: J Antibiot (Tokyo) Date: 1989-07 Impact factor: 2.649