Literature DB >> 1369016

Improved processes for the production and isolation of dynemicin A and large-scale fermentation in a 10,000-liter fermentor.

K S Lam1, J A Titus, T T Dabrah, D L Kimball, J M Veitch, D R Gustavson, B J Compton, J A Matson, S Forenza, J Ross.   

Abstract

Supplementing the culture of Micromonospora chersina sp. nov. No. M956-1 with NaI (0.5 mg/l) enhanced the production of dynemicin A by 35-fold in shake flask culture. Homogeneous dynemicin A was obtained from the whole broth extract by Dicalite chromatography, Sephadex LH-20 chromatography and vacuum liquid chromatography. Gram quantities of dynemicin A were obtained from the fermentation of M. chersina sp. nov. No. M956-1 in a 10,000-liter fermentor.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1369016     DOI： 10.1007/bf01583725

Source DB:  PubMed          Journal:  J Ind Microbiol        ISSN： 0169-4146


  9 in total

1.  New antibiotic produced by Micromonospora globosa.

Authors:  K Shiomi; H Iinuma; H Naganawa; M Hamada; S Hattori; H Nakamura; T Takeuchi; Y Iitaka
Journal:  J Antibiot (Tokyo)       Date:  1990-08       Impact factor: 2.649

2.  Nucleotide-specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibiotics.

Authors:  Y Sugiura; Y Uesawa; Y Takahashi; J Kuwahara; J Golik; T W Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

3.  DNA intercalation and cleavage of an antitumor antibiotic dynemicin that contains anthracycline and enediyne cores.

Authors:  Y Sugiura; T Shiraki; M Konishi; T Oki
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

4.  Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity.

Authors:  N Zein; M Poncin; R Nilakantan; G A Ellestad
Journal:  Science       Date:  1989-05-12       Impact factor: 47.728

5.  Dynemicin A, a novel antibiotic with the anthraquinone and 1,5-diyn-3-ene subunit.

Authors:  M Konishi; H Ohkuma; K Matsumoto; T Tsuno; H Kamei; T Miyaki; T Oki; H Kawaguchi; G D VanDuyne; J Clardy
Journal:  J Antibiot (Tokyo)       Date:  1989-09       Impact factor: 2.649

6.  Esperamicins, a novel class of potent antitumor antibiotics. I. Physico-chemical data and partial structure.

Authors:  M Konishi; H Ohkuma; K Saitoh; H Kawaguchi; J Golik; G Dubay; G Groenewold; B Krishnan; T W Doyle
Journal:  J Antibiot (Tokyo)       Date:  1985-11       Impact factor: 2.649

7.  Calicheamicin gamma 1I: an antitumor antibiotic that cleaves double-stranded DNA site specifically.

Authors:  N Zein; A M Sinha; W J McGahren; G A Ellestad
Journal:  Science       Date:  1988-05-27       Impact factor: 47.728

8.  Calicheamicins, a novel family of antitumor antibiotics: taxonomy, fermentation and biological properties.

Authors:  W M Maiese; M P Lechevalier; H A Lechevalier; J Korshalla; N Kuck; A Fantini; M J Wildey; J Thomas; M Greenstein
Journal:  J Antibiot (Tokyo)       Date:  1989-04       Impact factor: 2.649

9.  Esperamicins, a class of potent antitumor antibiotics: mechanism of action.

Authors:  B H Long; J Golik; S Forenza; B Ward; R Rehfuss; J C Dabrowiak; J J Catino; S T Musial; K W Brookshire; T W Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205
  9 in total
  3 in total

1.  Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234.

Authors:  Ling Liu; Jian Pan; Zilong Wang; Xiaohui Yan; Dong Yang; Xiangcheng Zhu; Ben Shen; Yanwen Duan; Yong Huang
Journal:  J Ind Microbiol Biotechnol       Date:  2018-02-02       Impact factor: 3.346

2.  Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates.

Authors:  Ajeeth Adhikari; Christiana N Teijaro; Xiaohui Yan; Chin-Yuan Chang; Chun Gui; Yu-Chen Liu; Ivana Crnovcic; Dong Yang; Thibault Annaval; Christoph Rader; Ben Shen
Journal:  J Med Chem       Date:  2020-07-24       Impact factor: 7.446

3.  Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production.

Authors:  Dong Yang; Jun Luo; Tingting Huang; Xiaohui Yan; Ajeeth Adhikari; Christiana N Teijaro; Huiming Ge; Ben Shen
Journal:  J Ind Microbiol Biotechnol       Date:  2021-06-04       Impact factor: 4.258
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.