Literature DB >> 27203374

The Structural Relationship between Iterative and Modular PKSs.

Adrian T Keatinge-Clay1.   

Abstract

Recent work has characterized the architecture of a highly-reducing iterative polyketide synthase (PKS), the mycocerosic acid synthase (MAS) (Herbst et al., 2016). Beyond sharing a structural similarity with the mammalian fatty acid synthase (FAS), the authors argue that the MAS architecture is representative of some PKS modules.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27203374      PMCID： PMC5460770          DOI： 10.1016/j.chembiol.2016.05.005

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN： 2451-9448            Impact factor:   8.116


  8 in total

1.  Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.

Authors:  Simon Jenni; Marc Leibundgut; Daniel Boehringer; Christian Frick; Bohdan Mikolásek; Nenad Ban
Journal:  Science       Date:  2007-04-13       Impact factor: 47.728

Review 2.  The structures of type I polyketide synthases.

Authors:  Adrian T Keatinge-Clay
Journal:  Nat Prod Rep       Date:  2012-08-03       Impact factor: 13.423

3.  Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases.

Authors:  Dominik A Herbst; Roman P Jakob; Franziska Zähringer; Timm Maier
Journal:  Nature       Date:  2016-03-14       Impact factor: 49.962

4.  The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.

Authors:  Darren C Gay; Drew T Wagner; Jessica L Meinke; Charles E Zogzas; Glen R Gay; Adrian T Keatinge-Clay
Journal:  J Struct Biol       Date:  2015-12-23       Impact factor: 2.867

Review 5.  Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids.

Authors:  Rajesh S Gokhale; Priti Saxena; Tarun Chopra; Debasisa Mohanty
Journal:  Nat Prod Rep       Date:  2007-02-28       Impact factor: 13.423

6.  Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase.

Authors:  Dheeraj Khare; Wendi A Hale; Ashootosh Tripathi; Liangcai Gu; David H Sherman; William H Gerwick; Kristina Håkansson; Janet L Smith
Journal:  Structure       Date:  2015-10-29       Impact factor: 5.006

7.  The crystal structure of a mammalian fatty acid synthase.

Authors:  Timm Maier; Marc Leibundgut; Nenad Ban
Journal:  Science       Date:  2008-09-05       Impact factor: 47.728

8.  Divergence of multimodular polyketide synthases revealed by a didomain structure.

Authors:  Jianting Zheng; Darren C Gay; Borries Demeler; Mark A White; Adrian T Keatinge-Clay
Journal:  Nat Chem Biol       Date:  2012-05-27       Impact factor: 15.040
  8 in total
  4 in total

Review 1.  The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.

Authors:  Adrian T Keatinge-Clay
Journal:  Chem Rev       Date:  2017-04-10       Impact factor: 60.622

2.  Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis.

Authors:  Cécile Bon; Stéphanie Cabantous; Sylviane Julien; Valérie Guillet; Christian Chalut; Julie Rima; Yoann Brison; Wladimir Malaga; Angelique Sanchez-Dafun; Sabine Gavalda; Annaïk Quémard; Julien Marcoux; Geoffrey S Waldo; Christophe Guilhot; Lionel Mourey
Journal:  BMC Biol       Date:  2022-06-21       Impact factor: 7.364

Review 3.  Protein-protein interactions in "cis-AT" polyketide synthases.

Authors:  Greg J Dodge; Finn P Maloney; Janet L Smith
Journal:  Nat Prod Rep       Date:  2018-10-17       Impact factor: 13.423

Review 4.  Towards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects.

Authors:  Carmen L Bayly; Vikramaditya G Yadav
Journal:  Molecules       Date:  2017-02-05       Impact factor: 4.411
  4 in total

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