Literature DB >> 22858605

The structures of type I polyketide synthases.

Adrian T Keatinge-Clay1.   

Abstract

With the recent structural characterization of each of the component enzymes of type I polyketide synthases, scientists are coming tantalizingly close to elucidating the overall architectures and mechanisms of these enormous molecular factories. This review highlights not only what has been revealed about the structures and activities of each of the domains but also the mysteries that remain to be solved.

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Year:  2012        PMID： 22858605     DOI： 10.1039/c2np20019h

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  118 in total

1.  Probing the modularity of megasynthases by rational engineering of a fatty acid synthase Type I.

Authors:  Alexander Rittner; Karthik S Paithankar; David Jan Drexler; Aaron Himmler; Martin Grininger
Journal:  Protein Sci       Date:  2018-12-20       Impact factor: 6.725

2.  Molecular dynamics studies of modular polyketide synthase ketoreductase stereospecificity.

Authors:  Mauro L Mugnai; Yue Shi; Adrian T Keatinge-Clay; Ron Elber
Journal:  Biochemistry       Date:  2015-04-02       Impact factor: 3.162

Review 3.  Engineering the acyltransferase substrate specificity of assembly line polyketide synthases.

Authors:  Briana J Dunn; Chaitan Khosla
Journal:  J R Soc Interface       Date:  2013-05-29       Impact factor: 4.118

4.  Structure determination of the functional domain interaction of a chimeric nonribosomal peptide synthetase from a challenging crystal with noncrystallographic translational symmetry.

Authors:  Jesse A Sundlov; Andrew M Gulick
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2013-07-18

5.  Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS.

Authors:  Manuel Fischer; Daniel Rhinow; Zhiwei Zhu; Deryck J Mills; Zongbao K Zhao; Janet Vonck; Martin Grininger
Journal:  Protein Sci       Date:  2015-04-02       Impact factor: 6.725

6.  Vinylogous chain branching catalysed by a dedicated polyketide synthase module.

Authors:  Tom Bretschneider; Joel B Heim; Daniel Heine; Robert Winkler; Benjamin Busch; Björn Kusebauch; Thilo Stehle; Georg Zocher; Christian Hertweck
Journal:  Nature       Date:  2013-09-18       Impact factor: 49.962

7.  Biosynthetic mechanism of very long chain polyunsaturated fatty acids in Thraustochytrium sp. 26185.

Authors:  Dauenpen Meesapyodsuk; Xiao Qiu
Journal:  J Lipid Res       Date:  2016-08-15       Impact factor: 5.922

8.  Identification and heterologous reconstitution of a 5-alk(en)ylresorcinol synthase from endophytic fungus Shiraia sp. Slf14.

Authors:  Huiwen Yan; Lei Sun; Jinge Huang; Yixing Qiu; Fuchao Xu; Riming Yan; Du Zhu; Wei Wang; Jixun Zhan
Journal:  J Microbiol       Date:  2018-10-24       Impact factor: 3.422

9.  Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases.

Authors:  Chen Wang; Xiaojing Wang; Liwen Zhang; Qun Yue; Qingpei Liu; Ya-Ming Xu; A A Leslie Gunatilaka; Xiaoyi Wei; Yuquan Xu; István Molnár
Journal:  J Am Chem Soc       Date:  2020-09-23       Impact factor: 15.419

Review 10.  Structural analysis of protein-protein interactions in type I polyketide synthases.

Authors:  Wei Xu; Kangjian Qiao; Yi Tang
Journal:  Crit Rev Biochem Mol Biol       Date:  2012-12-19       Impact factor: 8.250
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