Literature DB >> 27185879

Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease.

Fu Huang1, Susan M Abmayr2, Jerry L Workman3.   

Abstract

The lysine acetyltransferase 6 (KAT6) histone acetyltransferase (HAT) complexes are highly conserved from yeast to higher organisms. They acetylate histone H3 and other nonhistone substrates and are involved in cell cycle regulation and stem cell maintenance. In addition, the human KAT6 HATs are recurrently mutated in leukemia and solid tumors. Therefore, it is important to understand the mechanisms underlying the regulation of KAT6 HATs and their roles in cell cycle progression. In this minireview, we summarize the identification and analysis of the KAT6 complexes and discuss the regulatory mechanisms governing their enzymatic activities and substrate specificities. We further focus on the roles of KAT6 HATs in regulating cell proliferation and stem cell maintenance and review recent insights that aid in understanding their involvement in human diseases.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27185879      PMCID： PMC4936061          DOI： 10.1128/MCB.00055-16

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  77 in total

1.  A Drosophila chromatin factor interacts with the Piwi-interacting RNA mechanism in niche cells to regulate germline stem cell self-renewal.

Authors:  Tora K Smulders-Srinivasan; Akos Szakmary; Haifan Lin
Journal:  Genetics       Date:  2010-07-20       Impact factor: 4.562

2.  Dominant mutations in KAT6A cause intellectual disability with recognizable syndromic features.

Authors:  Emma Tham; Anna Lindstrand; Avni Santani; Helena Malmgren; Addie Nesbitt; Holly A Dubbs; Elaine H Zackai; Michael J Parker; Francisca Millan; Kenneth Rosenbaum; Golder N Wilson; Ann Nordgren
Journal:  Am J Hum Genet       Date:  2015-02-26       Impact factor: 11.025

3.  MOZ increases p53 acetylation and premature senescence through its complex formation with PML.

Authors:  Susumu Rokudai; Oleg Laptenko; Suzzette M Arnal; Yoichi Taya; Issay Kitabayashi; Carol Prives
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-19       Impact factor: 11.205

4.  Solution structure of an atypical PHD finger in BRPF2 and its interaction with DNA.

Authors:  Lei Liu; Su Qin; Jiahai Zhang; Peng Ji; Yunyu Shi; Jihui Wu
Journal:  J Struct Biol       Date:  2012-07-20       Impact factor: 2.867

5.  De novo mutations of the gene encoding the histone acetyltransferase KAT6B cause Genitopatellar syndrome.

Authors:  Michael A Simpson; Charu Deshpande; Dimitra Dafou; Lisenka E L M Vissers; Wesley J Woollard; Susan E Holder; Gabriele Gillessen-Kaesbach; Ronny Derks; Susan M White; Ruthy Cohen-Snuijf; Sarina G Kant; Lies H Hoefsloot; Willie Reardon; Han G Brunner; Ernie M H F Bongers; Richard C Trembath
Journal:  Am J Hum Genet       Date:  2012-01-19       Impact factor: 11.025

Review 6.  MOZ and MORF acetyltransferases: Molecular interaction, animal development and human disease.

Authors:  Xiang-Jiao Yang
Journal:  Biochim Biophys Acta       Date:  2015-04-25

7.  Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2.

Authors:  J Liang; L Prouty; B J Williams; M A Dayton; K L Blanchard
Journal:  Blood       Date:  1998-09-15       Impact factor: 22.113

8.  MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

Authors:  Brian J P Huntly; Hirokazu Shigematsu; Kenji Deguchi; Benjamin H Lee; Shinichi Mizuno; Nicky Duclos; Rebecca Rowan; Sonia Amaral; David Curley; Ifor R Williams; Koichi Akashi; D Gary Gilliland
Journal:  Cancer Cell       Date:  2004-12       Impact factor: 31.743

9.  Novel KAT6B-KANSL1 fusion gene identified by RNA sequencing in retroperitoneal leiomyoma with t(10;17)(q22;q21).

Authors:  Ioannis Panagopoulos; Ludmila Gorunova; Bodil Bjerkehagen; Sverre Heim
Journal:  PLoS One       Date:  2015-01-26       Impact factor: 3.240

10.  The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.

Authors:  Ingrid Dreveny; Sian E Deeves; Joel Fulton; Baigong Yue; Marie Messmer; Amit Bhattacharya; Hilary M Collins; David M Heery
Journal:  Nucleic Acids Res       Date:  2013-10-22       Impact factor: 16.971
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  26 in total

1.  Limiting PCNA-unloading at the G1/S transition.

Authors:  Fu Huang; Susan M Abmayr; Jerry L Workman
Journal:  Cell Cycle       Date:  2016-07-27       Impact factor: 4.534

2.  Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation.

Authors:  Eraj Shafiq Khokhar; Sneha Borikar; Elizabeth Eudy; Tim Stearns; Kira Young; Jennifer J Trowbridge
Journal:  Exp Hematol       Date:  2020-02-01       Impact factor: 3.084

Review 3.  Chromatin-Remodeled State in Lymphoma.

Authors:  Yuxuan Liu; Yulissa Gonzalez; Jennifer E Amengual
Journal:  Curr Hematol Malig Rep       Date:  2019-10       Impact factor: 3.952

4.  Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription.

Authors:  Shih-Ying Tsai; Fu Huang
Journal:  PLoS Genet       Date:  2021-02-01       Impact factor: 5.917

5.  Recognition of Histone H3K14 Acylation by MORF.

Authors:  Brianna J Klein; Johayra Simithy; Xiaolu Wang; JaeWoo Ahn; Forest H Andrews; Yi Zhang; Jacques Côté; Xiaobing Shi; Benjamin A Garcia; Tatiana G Kutateladze
Journal:  Structure       Date:  2017-03-09       Impact factor: 5.006

6.  Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction.

Authors:  Dick W Zijlmans; Irene Talon; Sigrid Verhelst; Adam Bendall; Karlien Van Nerum; Alok Javali; Andrew A Malcolm; Sam S F A van Knippenberg; Laura Biggins; San Kit To; Adrian Janiszewski; Danielle Admiraal; Ruth Knops; Nikky Corthout; Bradley P Balaton; Grigorios Georgolopoulos; Amitesh Panda; Natarajan V Bhanu; Amanda J Collier; Charlene Fabian; Ryan N Allsop; Joel Chappell; Thi Xuan Ai Pham; Michael Oberhuemer; Cankat Ertekin; Lotte Vanheer; Paraskevi Athanasouli; Frederic Lluis; Dieter Deforce; Joop H Jansen; Benjamin A Garcia; Michiel Vermeulen; Nicolas Rivron; Maarten Dhaenens; Hendrik Marks; Peter J Rugg-Gunn; Vincent Pasque
Journal:  Nat Cell Biol       Date:  2022-06-13       Impact factor: 28.213

7.  Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin.

Authors:  Brianna J Klein; Khan L Cox; Suk Min Jang; Jacques Côté; Michael G Poirier; Tatiana G Kutateladze
Journal:  Structure       Date:  2019-11-08       Impact factor: 5.006

8.  Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.

Authors:  Deguan Lv; Feng Jia; Yanli Hou; Youzhou Sang; Angel A Alvarez; Weiwei Zhang; Wei-Qiang Gao; Bo Hu; Shi-Yuan Cheng; Jianwei Ge; Yanxin Li; Haizhong Feng
Journal:  Cancer Res       Date:  2017-10-11       Impact factor: 12.701

9.  Investigation of the changes in the expression levels of MOZ gene in colorectal cancer tissues.

Authors:  Kiyanoush Mohammadi; Reza Safaralizadeh; Mohammadali Hosseinpour-Feizi; Narges Dastmalchi; Yaghoub Moaddab
Journal:  J Gastrointest Oncol       Date:  2019-02

10.  KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.

Authors:  Wenxue Liu; Zhiyan Zhan; Meiying Zhang; Bowen Sun; Qiqi Shi; Fei Luo; Mingda Zhang; Weiwei Zhang; Yanli Hou; Xiuying Xiao; Yanxin Li; Haizhong Feng
Journal:  Theranostics       Date:  2021-04-15       Impact factor: 11.556
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