Literature DB >> 27166097

Robust dipstick urinalysis using a low-cost, micro-volume slipping manifold and mobile phone platform.

Gennifer T Smith1, Nicholas Dwork1, Saara A Khan1, Matthew Millet1, Kiran Magar1, Mehdi Javanmard2, Audrey K Ellerbee Bowden1.   

Abstract

We introduce a novel manifold and companion software for dipstick urinalysis that eliminate many of the aspects that are traditionally plagued by user error: precise sample delivery, accurate readout timing, and controlled lighting conditions. The proposed all-acrylic slipping manifold is reusable, reliable, and low in cost. A simple timing mechanism ensures results are read out at the appropriate time. Results are obtained by capturing videos using a mobile phone and by analyzing them using custom-designed software. We show that the results obtained with the proposed device are as accurate and consistent as a properly executed dip-and-wipe method, the industry gold-standard, suggesting the potential for this strategy to enable confident urinalysis testing in home environments.

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Year:  2016        PMID: 27166097      PMCID: PMC4935544          DOI: 10.1039/c6lc00340k

Source DB:  PubMed          Journal:  Lab Chip        ISSN: 1473-0189            Impact factor:   6.799


  11 in total

1.  Integrated rapid-diagnostic-test reader platform on a cellphone.

Authors:  Onur Mudanyali; Stoyan Dimitrov; Uzair Sikora; Swati Padmanabhan; Isa Navruz; Aydogan Ozcan
Journal:  Lab Chip       Date:  2012-05-17       Impact factor: 6.799

2.  SlipChip for immunoassays in nanoliter volumes.

Authors:  Weishan Liu; Delai Chen; Wenbin Du; Kevin P Nichols; Rustem F Ismagilov
Journal:  Anal Chem       Date:  2010-04-15       Impact factor: 6.986

3.  Can urine dipstick testing for urinary tract infection at point of care reduce laboratory workload?

Authors:  H D Patel; S A Livsey; R A Swann; S S Bukhari
Journal:  J Clin Pathol       Date:  2005-09       Impact factor: 3.411

4.  Three-dimensional microfluidic devices fabricated in layered paper and tape.

Authors:  Andres W Martinez; Scott T Phillips; George M Whitesides
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-08       Impact factor: 11.205

5.  Point-of-care colorimetric detection with a smartphone.

Authors:  Li Shen; Joshua A Hagen; Ian Papautsky
Journal:  Lab Chip       Date:  2012-11-07       Impact factor: 6.799

6.  Nanoliter multiplex PCR arrays on a SlipChip.

Authors:  Feng Shen; Wenbin Du; Elena K Davydova; Mikhail A Karymov; Janmajay Pandey; Rustem F Ismagilov
Journal:  Anal Chem       Date:  2010-06-01       Impact factor: 6.986

7.  Development of the smartphone-based colorimetry for multi-analyte sensing arrays.

Authors:  Jong Il Hong; Byoung-Yong Chang
Journal:  Lab Chip       Date:  2014-03-27       Impact factor: 6.799

8.  Digital isothermal quantification of nucleic acids via simultaneous chemical initiation of recombinase polymerase amplification reactions on SlipChip.

Authors:  Feng Shen; Elena K Davydova; Wenbin Du; Jason E Kreutz; Olaf Piepenburg; Rustem F Ismagilov
Journal:  Anal Chem       Date:  2011-04-08       Impact factor: 6.986

9.  SlipChip.

Authors:  Wenbin Du; Liang Li; Kevin P Nichols; Rustem F Ismagilov
Journal:  Lab Chip       Date:  2009-05-15       Impact factor: 6.799

Review 10.  The urine dipstick test useful to rule out infections. A meta-analysis of the accuracy.

Authors:  Walter L J M Devillé; Joris C Yzermans; Nico P van Duijn; P Dick Bezemer; Daniëlle A W M van der Windt; Lex M Bouter
Journal:  BMC Urol       Date:  2004-06-02       Impact factor: 2.264

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  10 in total

Review 1.  New and developing diagnostic technologies for urinary tract infections.

Authors:  Michael Davenport; Kathleen E Mach; Linda M Dairiki Shortliffe; Niaz Banaei; Tza-Huei Wang; Joseph C Liao
Journal:  Nat Rev Urol       Date:  2017-03-01       Impact factor: 14.432

2.  A free customizable tool for easy integration of microfluidics and smartphones.

Authors:  Nazarena Pujato; Joana Macagno; Federico Schaumburg; Juan P Vidocevich; Gabriel S Gerlero; Pablo A Kler; Claudio L A Berli
Journal:  Sci Rep       Date:  2022-05-27       Impact factor: 4.996

Review 3.  Toilet-based continuous health monitoring using urine.

Authors:  Savas Tasoglu
Journal:  Nat Rev Urol       Date:  2022-01-21       Impact factor: 14.432

Review 4.  Urine biopsy technologies: Cancer and beyond.

Authors:  Chun Kwan Chen; Junchen Liao; Man Sze Li; Bee Luan Khoo
Journal:  Theranostics       Date:  2020-06-22       Impact factor: 11.556

5.  Color Space Transformation-Based Smartphone Algorithm for Colorimetric Urinalysis.

Authors:  Renbing Yang; Wenbo Cheng; Xifeng Chen; Qin Qian; Qiang Zhang; Yujun Pan; Peng Duan; Peng Miao
Journal:  ACS Omega       Date:  2018-09-27

Review 6.  Progress in Automated Urinalysis.

Authors:  Matthijs Oyaert; Joris Delanghe
Journal:  Ann Lab Med       Date:  2019-01       Impact factor: 3.464

7.  Integrated Digital Microfluidic Platform for Colorimetric Sensing of Nitrite.

Authors:  Zhen Gu; Ming-Lei Wu; Bing-Yong Yan; Hui-Feng Wang; Cong Kong
Journal:  ACS Omega       Date:  2020-05-04

Review 8.  Applications, challenges, and needs for employing synthetic biology beyond the lab.

Authors:  Sierra M Brooks; Hal S Alper
Journal:  Nat Commun       Date:  2021-03-02       Impact factor: 14.919

9.  Toward a Quantitative Colorimeter for Point-of-Care Nitrite Detection.

Authors:  Vince S Siu; Minhua Lu; Kuan Yu Hsieh; Kierstyn Raines; Youssef A Asaad; Krishna Patel; Ali Afzali-Ardakani; Bo Wen; Russell Budd
Journal:  ACS Omega       Date:  2022-03-22

10.  Development of a portable toolkit to diagnose coral thermal stress.

Authors:  Zhuolun Meng; Amanda Williams; Pinky Liau; Timothy G Stephens; Crawford Drury; Eric N Chiles; Xiaoyang Su; Mehdi Javanmard; Debashish Bhattacharya
Journal:  Sci Rep       Date:  2022-08-24       Impact factor: 4.996

  10 in total

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