Christian Benzing1, Nicco Krezdorn2, Julia Förster3, Andreas Hinz4, Felix Krenzien5, Georgi Atanasov5, Moritz Schmelzle5, Hans-Michael Hau3, Michael Bartels3. 1. Department of General, Visceral and Transplantation Surgery, Campus Virchow, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of General, Visceral, Thoracic and Vascular Surgery, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany. Electronic address: Christian.benzing@charite.de. 2. Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Carl-Neubergstr. 1, 30625 Hannover, Germany. 3. Department of Visceral, Transplantation, Thoracic, and Vascular Surgery, University Hospital Leipzig, Liebigstr. 20, 04103 Leipzig, Germany. 4. Department of Medical Psychology and Medical Sociology, University Hospital Leipzig, Philipp-Rosenthal-Str. 55, 04103 Leipzig, Germany. 5. Department of General, Visceral and Transplantation Surgery, Campus Virchow, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of General, Visceral, Thoracic and Vascular Surgery, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
Abstract
BACKGROUND: This study seeks to examine the impact of orthotopic liver transplantation (OLT) on Health-Related Quality of Life (HRQoL) and mental health in patients with different MELD scores. METHODS: Patients who has undergone orthotopic liver transplant (OLT) or were on the waiting list for OLT were submitted to HRQoL and depression/anxiety assessment by questionnaire: Short-Form 36 (SF-36), Questions on Life Satisfaction (FLZ-M), Patient Health Questionnaire-4 (PHQ-4). Data were analysed following division of patients into three groups: pretransplant patients with a MELD score <10, ≥10, and OLT recipients. RESULTS: The surveys were sent to 940 consecutive patients within one week in June 2013. Of these 940 patients, 869 (92.4%) met the inclusion criteria. In total, 291 (33.5%) eligible questionnaires (OLT group: 235, MELD <10: 25; MELD _10: 31) were suitable for analysis. General health (GH), vitality (VIT), and mental health (MH) were lower in both pretransplant groups compared to the OLT group (all p < 0.05). Anxiety and depression were higher in the MELD <10 group than in the OLT group (anxiety: p < 0.05; depression: p < 0.01). DISCUSSION: Patients with low MELD scores seem to benefit from OLT with regards to HRQoL and mental health.
BACKGROUND: This study seeks to examine the impact of orthotopic liver transplantation (OLT) on Health-Related Quality of Life (HRQoL) and mental health in patients with different MELD scores. METHODS:Patients who has undergone orthotopic liver transplant (OLT) or were on the waiting list for OLT were submitted to HRQoL and depression/anxiety assessment by questionnaire: Short-Form 36 (SF-36), Questions on Life Satisfaction (FLZ-M), Patient Health Questionnaire-4 (PHQ-4). Data were analysed following division of patients into three groups: pretransplant patients with a MELD score <10, ≥10, and OLT recipients. RESULTS: The surveys were sent to 940 consecutive patients within one week in June 2013. Of these 940 patients, 869 (92.4%) met the inclusion criteria. In total, 291 (33.5%) eligible questionnaires (OLT group: 235, MELD <10: 25; MELD _10: 31) were suitable for analysis. General health (GH), vitality (VIT), and mental health (MH) were lower in both pretransplant groups compared to the OLT group (all p < 0.05). Anxiety and depression were higher in the MELD <10 group than in the OLT group (anxiety: p < 0.05; depression: p < 0.01). DISCUSSION: Patients with low MELD scores seem to benefit from OLT with regards to HRQoL and mental health.
Authors: Sammy Saab; Ayman B Ibrahim; Alexander Shpaner; Zobair M Younossi; Cindy Lee; Francisco Durazo; Steven Han; Karl Esrason; Victor Wu; Jonathan Hiatt; Douglas G Farmer; R Mark Ghobrial; Curtis Holt; Hasan Yersiz; Leonard I Goldstein; Myron J Tong; Ronald W Busuttil Journal: Liver Transpl Date: 2005-02 Impact factor: 5.799
Authors: Robert M Merion; Douglas E Schaubel; Dawn M Dykstra; Richard B Freeman; Friedrich K Port; Robert A Wolfe Journal: Am J Transplant Date: 2005-02 Impact factor: 8.086
Authors: Sarwa Darwish Murad; Julie K Heimbach; Gregory J Gores; Charles B Rosen; Joanne T Benson; W Ray Kim Journal: Liver Transpl Date: 2013-04-09 Impact factor: 5.799
Authors: Johannes Broschewitz; Georg Wiltberger; Nicco Krezdorn; Felix Krenzien; Julia Förster; Georgi Atanasov; Hans-Michael Hau; Moritz Schmelzle; Andreas Hinz; Michael Bartels; Christian Benzing Journal: Health Qual Life Outcomes Date: 2017-07-21 Impact factor: 3.186
Authors: Alessandra Agnese Grossi; Federico Nicoli; Tullia Maria De Feo; Massimo Cardillo; Gabriella Biffa; Renzo Pegoraro; Carlo Petrini; Rosanna Torelli; Francesca Puoti; Giuseppe Rossini; Giuseppe Piccolo; Sergio Vesconi; Enrico Minetti; Barbara Pozzo; Giuseppe Vanacore; David Paredes; Paolo Antonio Grossi; Mario Picozzi Journal: Transplant Direct Date: 2021-10-22