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Literature DB >> 27128603

7SKiing on chromatin: Move globally, act locally.

Abstract

RNA polymerase II (Pol II) pausing at promoter-proximal regions is a highly regulated step in the transcription cycle. Pause release is facilitated by the P-TEFb kinase, which phosphorylates Pol II and negative elongation factors. Recent studies suggest that P-TEFb (as part of the inhibitory 7SK snRNP) is recruited to promoter-proximal regions through interaction with KAP1/TRIM28/TIF1β to facilitate 'on-site' kinase activation and transcription elongation. Here, I discuss features of this model and future challenges to further hone our understanding of transcriptional regulation including Pol II pausing and pause release.

Entities: Chemical Gene

Keywords: 7SK snRNP; KAP1/TRIM28; P-TEFb; RNA polymerase II; transcription elongation

Mesh：

Substances：

Year: 2016 PMID： 27128603 PMCID： PMC4962805 DOI： 10.1080/15476286.2016.1181254

Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652

66 in total

1. Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion.

Authors: Matjaz Barboric; Tina Lenasi
Journal: Nat Struct Mol Biol Date: 2010-08 Impact factor: 15.369

Review 2. Transcriptional elongation checkpoint control in development and disease.

Authors: Edwin Smith; Ali Shilatifard
Journal: Genes Dev Date: 2013-05-15 Impact factor: 11.361

Review 3. The super elongation complex (SEC) family in transcriptional control.

Authors: Zhuojuan Luo; Chengqi Lin; Ali Shilatifard
Journal: Nat Rev Mol Cell Biol Date: 2012-08-16 Impact factor: 94.444

4. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription.

Authors: T J Fu; J Peng; G Lee; D H Price; O Flores
Journal: J Biol Chem Date: 1999-12-03 Impact factor: 5.157

5. KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.

Authors: Ryan P McNamara; Jonathan E Reeder; Elizabeth A McMillan; Curtis W Bacon; Jennifer L McCann; Iván D'Orso
Journal: Mol Cell Date: 2015-12-24 Impact factor: 17.970

6. CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA.

Authors: M E Garber; T P Mayall; E M Suess; J Meisenhelder; N E Thompson; K A Jones
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

7. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.

Authors: Yael Ziv; Dana Bielopolski; Yaron Galanty; Claudia Lukas; Yoichi Taya; David C Schultz; Jiri Lukas; Simon Bekker-Jensen; Jiri Bartek; Yosef Shiloh
Journal: Nat Cell Biol Date: 2006-07-23 Impact factor: 28.824

8. Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat.

Authors: Lisa Muniz; Sylvain Egloff; Bettina Ughy; Beáta E Jády; Tamás Kiss
Journal: PLoS Pathog Date: 2010-10-14 Impact factor: 6.823

9. The CDK Network: Linking Cycles of Cell Division and Gene Expression.

Authors: Robert P Fisher
Journal: Genes Cancer Date: 2012-11

10. TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release.

Authors: Heeyoun Bunch; Xiaofeng Zheng; Adam Burkholder; Simon T Dillon; Shmulik Motola; Gabriel Birrane; Christopher C Ebmeier; Stuart Levine; David Fargo; Guang Hu; Dylan J Taatjes; Stuart K Calderwood
Journal: Nat Struct Mol Biol Date: 2014-08-31 Impact factor: 15.369

11 in total

7SKiing on chromatin: Move globally, act locally.

1. Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion.

Review 2. Transcriptional elongation checkpoint control in development and disease.

Review 3. The super elongation complex (SEC) family in transcriptional control.

4. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription.

5. KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.

6. CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA.

7. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.

8. Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat.

9. The CDK Network: Linking Cycles of Cell Division and Gene Expression.

10. TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release.

1. Tandem Affinity Purification of Protein Complexes from Eukaryotic Cells.

Review 2. Hexim1, an RNA-controlled protein hub.

3. Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism.

4. Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

Review 5. The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system.

6. P-TEFb Regulates Transcriptional Activation in Non-coding RNA Genes.

Review 7. HIV-1 Proviral Transcription and Latency in the New Era.

Review 8. CDK9 keeps RNA polymerase II on track.

9. Non-Coding RNAs As Transcriptional Regulators In Eukaryotes.

10. KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity.