Literature DB >> 33160830

The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system.

Sean Paz1, Anastasia Ritchie1, Christopher Mauer1, Massimo Caputi2.   

Abstract

Serine/Arginine splicing factor 1 (SRSF1) is an RNA binding protein abundantly expressed in most tissues. The pleiotropic functions of SRSF1 exert multiple roles in gene expression by regulating major steps in transcription, processing, export through the nuclear pores and translation of nascent RNA transcripts. The aim of this review is to highlight recent findings in the functions of this protein and to describe its role in immune system development, functions and regulation.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  SLE; SR protein; Splicing; Transcription; Translation; mRNA; miRNA

Mesh：

Substances：

Year:  2020        PMID： 33160830      PMCID： PMC7897272          DOI： 10.1016/j.cytogfr.2020.10.008

Source DB:  PubMed          Journal:  Cytokine Growth Factor Rev        ISSN： 1359-6101            Impact factor:   7.638


  90 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2011-05-02       Impact factor: 11.205

2.  SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus.

Authors:  Yuka Kawaguchi; Hiroaki Nariki; Naoko Kawamoto; Yuichi Kanehiro; Satoshi Miyazaki; Mari Suzuki; Masaki Magari; Hiroshi Tokumitsu; Naoki Kanayama
Journal:  Biochem Biophys Res Commun       Date:  2017-02-21       Impact factor: 3.575

Review 3.  Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages.

Authors:  Mayra Solis; Delphine Goubau; Raphaëlle Romieu-Mourez; Pierre Genin; Ahmet Civas; John Hiscott
Journal:  Biochem Pharmacol       Date:  2006-07-17       Impact factor: 5.858

Review 4.  Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways.

Authors:  Xiuli Liu; W Lee Kraus; Xiaoying Bai
Journal:  Trends Biochem Sci       Date:  2015-08-04       Impact factor: 13.807

5.  Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.

Authors:  Li Ma; Julie Teruya-Feldstein; Robert A Weinberg
Journal:  Nature       Date:  2007-09-26       Impact factor: 49.962

6.  microRNA-mediated regulation of splicing factors SRSF1, SRSF2 and hnRNP A1 in context of their alternatively spliced 3'UTRs.

Authors:  Elżbieta Sokół; Hanna Kędzierska; Alicja Czubaty; Beata Rybicka; Katarzyna Rodzik; Zbigniew Tański; Joanna Bogusławska; Agnieszka Piekiełko-Witkowska
Journal:  Exp Cell Res       Date:  2018-01-10       Impact factor: 3.905

7.  Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing.

Authors:  Madapura M Pradeepa; Heidi G Sutherland; Jernej Ule; Graeme R Grimes; Wendy A Bickmore
Journal:  PLoS Genet       Date:  2012-05-17       Impact factor: 5.917

Review 8.  SR Proteins: Binders, Regulators, and Connectors of RNA.

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Journal:  Mol Cells       Date:  2017-01-26       Impact factor: 5.034

9.  MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells.

Authors:  C Botta; M Cucè; M R Pitari; D Caracciolo; A Gullà; E Morelli; C Riillo; L Biamonte; M E Gallo Cantafio; R Prabhala; C Mignogna; A Di Vito; E Altomare; N Amodio; M T Di Martino; P Correale; M Rossi; A Giordano; N C Munshi; P Tagliaferri; P Tassone
Journal:  Leukemia       Date:  2017-11-21       Impact factor: 11.528

10.  Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease.

Authors:  Peter A Szabo; Hanna Mendes Levitin; Michelle Miron; Mark E Snyder; Takashi Senda; Jinzhou Yuan; Yim Ling Cheng; Erin C Bush; Pranay Dogra; Puspa Thapa; Donna L Farber; Peter A Sims
Journal:  Nat Commun       Date:  2019-10-17       Impact factor: 14.919
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  13 in total

Review 1.  Drug delivery approaches for HuR-targeted therapy for lung cancer.

Authors:  Rajeswari Raguraman; Santny Shanmugarama; Meghna Mehta; Jo Elle Peterson; Yan D Zhao; Anupama Munshi; Rajagopal Ramesh
Journal:  Adv Drug Deliv Rev       Date:  2021-11-22       Impact factor: 15.470

2.  Dynamics and functional roles of splicing factor autoregulation.

Authors:  Fangyuan Ding; Christina J Su; KeHuan Kuo Edmonds; Guohao Liang; Michael B Elowitz
Journal:  Cell Rep       Date:  2022-06-21       Impact factor: 9.995

3.  Mutation update of SERPING1 related to hereditary angioedema in the Chinese population.

Authors:  Xue Wang; Shubin Lei; Yingyang Xu; Shuang Liu; Yuxiang Zhi
Journal:  Hereditas       Date:  2022-07-11       Impact factor: 2.595

Review 4.  Alternative Splicing of Pre-mRNA in the Control of Immune Activity.

Authors:  Zhongjing Su; Dongyang Huang
Journal:  Genes (Basel)       Date:  2021-04-15       Impact factor: 4.096

5.  The nuclear transcription factor, TAF7, is a cytoplasmic regulator of protein synthesis.

Authors:  Dan Cheng; Kevin Semmens; Elizabeth McManus; Qingrong Chen; Daoud Meerzaman; Xiantao Wang; Markus Hafner; Brian A Lewis; Hidehisa Takahashi; Ballachanda N Devaiah; Anne Gegonne; Dinah S Singer
Journal:  Sci Adv       Date:  2021-12-10       Impact factor: 14.136

Review 6.  Nuclear mRNA Quality Control and Cytoplasmic NMD Are Linked by the Guard Proteins Gbp2 and Hrb1.

Authors:  Yen-Yun Lu; Heike Krebber
Journal:  Int J Mol Sci       Date:  2021-10-19       Impact factor: 5.923

7.  Comprehensive Analysis of circRNA-miRNA-mRNA Regulatory Network and Novel Potential Biomarkers in Acute Myocardial Infarction.

Authors:  Jiahe Wu; Chenze Li; Zhe Lei; Huanhuan Cai; Yushuang Hu; Yanfang Zhu; Tong Zhang; Haoyan Zhu; Jianlei Cao; Xiaorong Hu
Journal:  Front Cardiovasc Med       Date:  2022-07-07

8.  An IGF-1R-mTORC1-SRPK2 signaling Axis contributes to FASN regulation in breast cancer.

Authors:  Bryan McClellan; Paul Gries; Brittany Harlow; Stefano Tiziani; Christopher Jolly; Linda deGraffenried
Journal:  BMC Cancer       Date:  2022-09-12       Impact factor: 4.638

Review 9.  Emerging roles of spliceosome in cancer and immunity.

Authors:  Hui Yang; Bruce Beutler; Duanwu Zhang
Journal:  Protein Cell       Date:  2021-07-01       Impact factor: 15.328

10.  Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function.

Authors:  Fiona Haward; Magdalena M Maslon; Patricia L Yeyati; Nicolas Bellora; Jan N Hansen; Stuart Aitken; Jennifer Lawson; Alex von Kriegsheim; Dagmar Wachten; Pleasantine Mill; Ian R Adams; Javier F Caceres
Journal:  Elife       Date:  2021-08-02       Impact factor: 8.140
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