Yuri Fujino1, Ryo Asaoka1, Hiroshi Murata1, Atsuya Miki2, Masaki Tanito3, Shiro Mizoue4, Kazuhiko Mori5, Katsuyoshi Suzuki6, Takehiro Yamashita7, Kenji Kashiwagi8, Nobuyuki Shoji9. 1. Department of Ophthalmology The University of Tokyo, Tokyo, Japan. 2. Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan. 3. Department of Ophthalmology, Shimane University Faculty of Medicine, Shimane, Japan 4Division of Ophthalmology, Matsue Red Cross Hospital, Shimane, Japan. 4. Department of Ophthalmology, Ehime University Graduate School of Medicine, Ehime, Japan. 5. Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan. 6. Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan. 7. Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. 8. Department of Ophthalmology, University of Yamanashi Faculty of Medicine, Yamanashi, Japan. 9. Orthoptics and Visual Science, Department of Rehabilitation, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan.
Abstract
PURPOSE: To develop a large-scale real clinical database of glaucoma (Japanese Archive of Multicentral Databases in Glaucoma: JAMDIG) and to investigate the effect of treatment. METHODS: The study included a total of 1348 eyes of 805 primary open-angle glaucoma patients with 10 visual fields (VFs) measured with 24-2 or 30-2 Humphrey Field Analyzer (HFA) and intraocular pressure (IOP) records in 10 institutes in Japan. Those with 10 reliable VFs were further identified (638 eyes of 417 patients). Mean total deviation (mTD) of the 52 test points in the 24-2 HFA VF was calculated, and the relationship between mTD progression rate and seven variables (age, mTD of baseline VF, average IOP, standard deviation (SD) of IOP, previous argon/selective laser trabeculoplasties (ALT/SLT), previous trabeculectomy, and previous trabeculotomy) was analyzed. RESULTS: The mTD in the initial VF was -6.9 ± 6.2 dB and the mTD progression rate was -0.26 ± 0.46 dB/year. Mean IOP during the follow-up period was 13.5 ± 2.2 mm Hg. Age and SD of IOP were related to mTD progression rate. However, in eyes with average IOP below 15 and also 13 mm Hg, only age and baseline VF mTD were related to mTD progression rate. CONCLUSIONS: Age and the degree of VF damage were related to future progression. Average IOP was not related to the progression rate; however, fluctuation of IOP was associated with faster progression, although this was not the case when average IOP was below 15 mm Hg.
PURPOSE: To develop a large-scale real clinical database of glaucoma (Japanese Archive of Multicentral Databases in Glaucoma: JAMDIG) and to investigate the effect of treatment. METHODS: The study included a total of 1348 eyes of 805 primary open-angle glaucomapatients with 10 visual fields (VFs) measured with 24-2 or 30-2 Humphrey Field Analyzer (HFA) and intraocular pressure (IOP) records in 10 institutes in Japan. Those with 10 reliable VFs were further identified (638 eyes of 417 patients). Mean total deviation (mTD) of the 52 test points in the 24-2 HFA VF was calculated, and the relationship between mTD progression rate and seven variables (age, mTD of baseline VF, average IOP, standard deviation (SD) of IOP, previous argon/selective laser trabeculoplasties (ALT/SLT), previous trabeculectomy, and previous trabeculotomy) was analyzed. RESULTS: The mTD in the initial VF was -6.9 ± 6.2 dB and the mTD progression rate was -0.26 ± 0.46 dB/year. Mean IOP during the follow-up period was 13.5 ± 2.2 mm Hg. Age and SD of IOP were related to mTD progression rate. However, in eyes with average IOP below 15 and also 13 mm Hg, only age and baseline VF mTD were related to mTD progression rate. CONCLUSIONS: Age and the degree of VF damage were related to future progression. Average IOP was not related to the progression rate; however, fluctuation of IOP was associated with faster progression, although this was not the case when average IOP was below 15 mm Hg.
Authors: Mae O Gordon; Feng Gao; Julia Beiser Huecker; J Philip Miller; Mathew Margolis; Michael A Kass; Stefano Miglior; Valter Torri Journal: JAMA Ophthalmol Date: 2020-07-01 Impact factor: 8.253