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Literature DB >> 27100743

A critical role for topoisomerase IIb and DNA double strand breaks in transcription.

Abstract

Recent studies have indicated a novel role for topoisomerase IIb in transcription. Transcription of heat shock genes, serum-induced immediate early genes and nuclear receptor-activated genes, each required DNA double strands generated by topoisomerase IIb. Such strand breaks seemed both necessary and sufficient for transcriptional activation. In addition, such transcription was associated with initiation of the DNA damage response pathways, including the activation of the enzymes: ataxia-telangiectasia mutated (ATM), DNA-dependent protein kinase and poly (ADP ribose) polymerase 1. DNA damage response signaling was involved both in transcription and in repair of DNA breaks generated by topoisomerase IIb.

Entities: Gene

Keywords: ATM; DNA-PK; PARP1; PIKK kinase; strand break; topoisomerase II; transcripton

Mesh：

Substances：

Year: 2016 PMID： 27100743 PMCID： PMC4984685 DOI： 10.1080/21541264.2016.1181142

Source DB: PubMed Journal: Transcription ISSN： 2154-1272

62 in total

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10. TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release.

Authors: Heeyoun Bunch; Xiaofeng Zheng; Adam Burkholder; Simon T Dillon; Shmulik Motola; Gabriel Birrane; Christopher C Ebmeier; Stuart Levine; David Fargo; Guang Hu; Dylan J Taatjes; Stuart K Calderwood
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Review 2. DNA double-strand breaks as drivers of neural genomic change, function, and disease.

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4. The DNA Repair-Associated Protein Gadd45γ Regulates the Temporal Coding of Immediate Early Gene Expression within the Prelimbic Prefrontal Cortex and Is Required for the Consolidation of Associative Fear Memory.

Authors: Xiang Li; Paul R Marshall; Laura J Leighton; Esmi L Zajaczkowski; Ziqi Wang; Sachithrani U Madugalle; Jiayu Yin; Timothy W Bredy; Wei Wei
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Review 9. Programmed DNA Damage and Physiological DSBs: Mapping, Biological Significance and Perturbations in Disease States.

Authors: Sara Oster; Rami I Aqeilan
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Review 10. Tetrahymena meiosis: Simple yet ingenious.

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