Literature DB >> 30195640

DNA double-strand breaks as drivers of neural genomic change, function, and disease.

Frederick W Alt1, Bjoern Schwer2.   

Abstract

Early work from about two decades ago implicated DNA double-strand break (DSB) formation and repair in neuronal development. Findings emerging from recent studies of DSBs in proliferating neural progenitors and in mature, non-dividing neurons suggest important roles of DSBs in brain physiology, aging, cancer, psychiatric and neurodegenerative disorders. We provide an overview of some findings and speculate on what may lie ahead.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Copy number variations; DNA double-strand breaks; DNA repair; DNA replication; Exon shuffling; Genomic instability; Neural stem and progenitor cells; Neurodevelopment; Neurons; Non-homologous end joining; Somatic mosaicism; Transcription

Mesh：

Substances：

Year:  2018        PMID： 30195640      PMCID： PMC6340756          DOI： 10.1016/j.dnarep.2018.08.019

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  73 in total

1.  Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis.

Authors:  J M Sekiguchi; Y Gao; Y Gu; K Frank; Y Sun; J Chaudhuri; C Zhu; H L Cheng; J Manis; D Ferguson; L Davidson; M E Greenberg; F W Alt
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1999

Review 2.  Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles.

Authors:  Bushra Raj; Benjamin J Blencowe
Journal:  Neuron       Date:  2015-07-01       Impact factor: 17.173

3.  Glucocorticoid Receptor Transcriptional Activation via the BRG1-Dependent Recruitment of TOP2β and Ku70/86.

Authors:  Kevin W Trotter; Heather A King; Trevor K Archer
Journal:  Mol Cell Biol       Date:  2015-06-08       Impact factor: 4.272

4.  Anthracyclines induce double-strand DNA breaks at active gene promoters.

Authors:  Fan Yang; Christopher J Kemp; Steven Henikoff
Journal:  Mutat Res       Date:  2015-03       Impact factor: 2.433

Review 5.  Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.

Authors:  Michael J McConnell; John V Moran; Alexej Abyzov; Schahram Akbarian; Taejeong Bae; Isidro Cortes-Ciriano; Jennifer A Erwin; Liana Fasching; Diane A Flasch; Donald Freed; Javier Ganz; Andrew E Jaffe; Kenneth Y Kwan; Minseok Kwon; Michael A Lodato; Ryan E Mills; Apua C M Paquola; Rachel E Rodin; Chaggai Rosenbluh; Nenad Sestan; Maxwell A Sherman; Joo Heon Shin; Saera Song; Richard E Straub; Jeremy Thorpe; Daniel R Weinberger; Alexander E Urban; Bo Zhou; Fred H Gage; Thomas Lehner; Geetha Senthil; Christopher A Walsh; Andrew Chess; Eric Courchesne; Joseph G Gleeson; Jeffrey M Kidd; Peter J Park; Jonathan Pevsner; Flora M Vaccarino
Journal:  Science       Date:  2017-04-27       Impact factor: 47.728

Review 6.  Identification of early replicating fragile sites that contribute to genome instability.

Authors:  Jacqueline H Barlow; Robert B Faryabi; Elsa Callén; Nancy Wong; Amy Malhowski; Hua Tang Chen; Gustavo Gutierrez-Cruz; Hong-Wei Sun; Peter McKinnon; George Wright; Rafael Casellas; Davide F Robbiani; Louis Staudt; Oscar Fernandez-Capetillo; André Nussenzweig
Journal:  Cell       Date:  2013-01-24       Impact factor: 41.582

Review 7.  Mechanisms of programmed DNA lesions and genomic instability in the immune system.

Authors:  Frederick W Alt; Yu Zhang; Fei-Long Meng; Chunguang Guo; Bjoern Schwer
Journal:  Cell       Date:  2013-01-31       Impact factor: 41.582

8.  Transcription-dependent dynamic supercoiling is a short-range genomic force.

Authors:  Fedor Kouzine; Ashutosh Gupta; Laura Baranello; Damian Wojtowicz; Khadija Ben-Aissa; Juhong Liu; Teresa M Przytycka; David Levens
Journal:  Nat Struct Mol Biol       Date:  2013-02-17       Impact factor: 15.369

9.  Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders.

Authors:  Liis Uusküla-Reimand; Huayun Hou; Payman Samavarchi-Tehrani; Matteo Vietri Rudan; Minggao Liang; Alejandra Medina-Rivera; Hisham Mohammed; Dominic Schmidt; Petra Schwalie; Edwin J Young; Jüri Reimand; Suzana Hadjur; Anne-Claude Gingras; Michael D Wilson
Journal:  Genome Biol       Date:  2016-08-31       Impact factor: 13.583

Review 10.  Genome integrity and disease prevention in the nervous system.

Authors:  Peter J McKinnon
Journal:  Genes Dev       Date:  2017-06-15       Impact factor: 11.361
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  29 in total

Review 1.  DNA double-strand breaks: a potential therapeutic target for neurodegenerative diseases.

Authors:  Nidheesh Thadathil; Roderick Hori; Jianfeng Xiao; Mohammad Moshahid Khan
Journal:  Chromosome Res       Date:  2019-11-09       Impact factor: 5.239

Review 2.  On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability.

Authors:  Alexandra N Khristich; Sergei M Mirkin
Journal:  J Biol Chem       Date:  2020-02-14       Impact factor: 5.157

3.  High-resolution, ultrasensitive and quantitative DNA double-strand break labeling in eukaryotic cells using i-BLESS.

Authors:  Anna Biernacka; Magdalena Skrzypczak; Yingjie Zhu; Philippe Pasero; Maga Rowicka; Krzysztof Ginalski
Journal:  Nat Protoc       Date:  2020-12-21       Impact factor: 13.491

Review 4.  The Role of Transposable Elements of the Human Genome in Neuronal Function and Pathology.

Authors:  Ekaterina Chesnokova; Alexander Beletskiy; Peter Kolosov
Journal:  Int J Mol Sci       Date:  2022-05-23       Impact factor: 6.208

Review 5.  Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases.

Authors:  Xiaoling Li; Guanghui Cao; Xiaokang Liu; Tie-Shan Tang; Caixia Guo; Hongmei Liu
Journal:  Front Cell Neurosci       Date:  2022-06-30       Impact factor: 6.147

6.  Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome.

Authors:  Melody P Lun; Morgan L Shannon; Sevgi Keles; Ismail Reisli; Nicole Luche; Douglas Ryan; Kelly Capuder; Luigi D Notarangelo; Maria K Lehtinen
Journal:  Am J Pathol       Date:  2019-09-18       Impact factor: 4.307

7.  Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.

Authors:  Anirban Chakraborty; Nisha Tapryal; Tatiana Venkova; Joy Mitra; Velmarini Vasquez; Altaf H Sarker; Sara Duarte-Silva; Weihan Huai; Tetsuo Ashizawa; Gourisankar Ghosh; Patricia Maciel; Partha S Sarkar; Muralidhar L Hegde; Xu Chen; Tapas K Hazra
Journal:  Proc Natl Acad Sci U S A       Date:  2020-03-23       Impact factor: 11.205

Review 8.  The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication.

Authors:  Madalena Tarsounas; Patrick Sung
Journal:  Nat Rev Mol Cell Biol       Date:  2020-02-24       Impact factor: 94.444

Review 9.  The role of somatic mosaicism in brain disease.

Authors:  Alexandre Jourdon; Liana Fasching; Soraya Scuderi; Alexej Abyzov; Flora M Vaccarino
Journal:  Curr Opin Genet Dev       Date:  2020-07-01       Impact factor: 5.578

10.  Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization.

Authors:  Natalie Tabor; Conelius Ngwa; Jeremie Mitteaux; Matthew D Meyer; Jose F Moruno-Manchon; Liang Zhu; Fudong Liu; David Monchaud; Louise D McCullough; Andrey S Tsvetkov
Journal:  Aging (Albany NY)       Date:  2021-06-19       Impact factor: 5.682
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