Literature DB >> 28787588

Anchoring Chromatin Loops to Cancer.

Faith Fowler1, Jessica K Tyler2.   

Abstract

Although some genomic rearrangements are caused by replication or transcription, the etiology of others is unclear. Reporting in Cell, Canela et al. (2017) reveal that type II topoisomerase-mediated release of torsional strain at chromosomal loop anchors generates DNA double-strand breaks that drive multiple oncogenic translocations in a transcription-independent manner.
Copyright © 2017. Published by Elsevier Inc.

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Year:  2017        PMID： 28787588      PMCID： PMC5859922          DOI： 10.1016/j.devcel.2017.07.013

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  10 in total

1.  A critical role for topoisomerase IIb and DNA double strand breaks in transcription.

Authors:  Stuart K Calderwood
Journal:  Transcription       Date:  2016-04-21

2.  Genome Organization Drives Chromosome Fragility.

Authors:  Andres Canela; Yaakov Maman; Seolkyoung Jung; Nancy Wong; Elsa Callen; Amanda Day; Kyong-Rim Kieffer-Kwon; Aleksandra Pekowska; Hongliang Zhang; Suhas S P Rao; Su-Chen Huang; Peter J Mckinnon; Peter D Aplan; Yves Pommier; Erez Lieberman Aiden; Rafael Casellas; André Nussenzweig
Journal:  Cell       Date:  2017-07-20       Impact factor: 41.582

Review 3.  Chromatin Domains: The Unit of Chromosome Organization.

Authors:  Jesse R Dixon; David U Gorkin; Bing Ren
Journal:  Mol Cell       Date:  2016-06-02       Impact factor: 17.970

Review 4.  The incidence of secondary leukemias.

Authors:  G Leone; L Mele; A Pulsoni; F Equitani; L Pagano
Journal:  Haematologica       Date:  1999-10       Impact factor: 9.941

5.  DNA Breaks and End Resection Measured Genome-wide by End Sequencing.

Authors:  Andres Canela; Sriram Sridharan; Nicholas Sciascia; Anthony Tubbs; Paul Meltzer; Barry P Sleckman; André Nussenzweig
Journal:  Mol Cell       Date:  2016-07-28       Impact factor: 17.970

6.  3D Chromosome Regulatory Landscape of Human Pluripotent Cells.

Authors:  Xiong Ji; Daniel B Dadon; Benjamin E Powell; Zi Peng Fan; Diego Borges-Rivera; Sigal Shachar; Abraham S Weintraub; Denes Hnisz; Gianluca Pegoraro; Tong Ihn Lee; Tom Misteli; Rudolf Jaenisch; Richard A Young
Journal:  Cell Stem Cell       Date:  2015-12-10       Impact factor: 24.633

7.  Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.

Authors:  Joachim Weischenfeldt; Taronish Dubash; Alexandros P Drainas; Balca R Mardin; Yuanyuan Chen; Adrian M Stütz; Sebastian M Waszak; Graziella Bosco; Ann Rita Halvorsen; Benjamin Raeder; Theocharis Efthymiopoulos; Serap Erkek; Christine Siegl; Hermann Brenner; Odd Terje Brustugun; Sebastian M Dieter; Paul A Northcott; Iver Petersen; Stefan M Pfister; Martin Schneider; Steinar K Solberg; Erik Thunissen; Wilko Weichert; Thomas Zichner; Roman Thomas; Martin Peifer; Aslaug Helland; Claudia R Ball; Martin Jechlinger; Rocio Sotillo; Hanno Glimm; Jan O Korbel
Journal:  Nat Genet       Date:  2016-11-21       Impact factor: 38.330

Review 8.  Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control.

Authors:  Denes Hnisz; Daniel S Day; Richard A Young
Journal:  Cell       Date:  2016-11-17       Impact factor: 41.582

9.  Activation of proto-oncogenes by disruption of chromosome neighborhoods.

Authors:  Denes Hnisz; Abraham S Weintraub; Daniel S Day; Anne-Laure Valton; Rasmus O Bak; Charles H Li; Johanna Goldmann; Bryan R Lajoie; Zi Peng Fan; Alla A Sigova; Jessica Reddy; Diego Borges-Rivera; Tong Ihn Lee; Rudolf Jaenisch; Matthew H Porteus; Job Dekker; Richard A Young
Journal:  Science       Date:  2016-03-03       Impact factor: 47.728

10.  Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells.

Authors:  Roberto Chiarle; Yu Zhang; Richard L Frock; Susanna M Lewis; Benoit Molinie; Yu-Jui Ho; Darienne R Myers; Vivian W Choi; Mara Compagno; Daniel J Malkin; Donna Neuberg; Stefano Monti; Cosmas C Giallourakis; Monica Gostissa; Frederick W Alt
Journal:  Cell       Date:  2011-09-30       Impact factor: 41.582
  10 in total
  2 in total

1.  Regional Gene Repression by DNA Double-Strand Breaks in G1 Phase Cells.

Authors:  Caitlin E Purman; Patrick L Collins; Sofia I Porter; Ankita Saini; Harshath Gupta; Barry P Sleckman; Eugene M Oltz
Journal:  Mol Cell Biol       Date:  2019-11-25       Impact factor: 4.272

Review 2.  Topoisomerases and cancer chemotherapy: recent advances and unanswered questions.

Authors:  Mary-Ann Bjornsti; Scott H Kaufmann
Journal:  F1000Res       Date:  2019-09-30
  2 in total

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