Literature DB >> 2707207

Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database.

L S Gold1, T H Slone, L Bernstein.   

Abstract

A tabulation of carcinogenic potency (TD50) by species for 492 chemicals that induce tumors in rats or mice is presented. With the use of the Carcinogenic Potency Database, experimental results are summarized by indicating in which sex-species groups the chemical was tested and the respective evaluations of carcinogenicity. A comparison of three summary measures of TD50 for chemicals with more than one positive experiment per species shows that the most potent TD50 value is similar to measures that average values or functions of values. This tabulation can be used to investigate associations between rodent potency and other factors such as mutagenicity, teratogenicity, chemical structure, and human exposure.

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Year:  1989        PMID： 2707207      PMCID： PMC1567574          DOI： 10.1289/ehp.8979259

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  10 in total

1.  Ranking possible carcinogenic hazards.

Authors:  B N Ames; R Magaw; L S Gold
Journal:  Science       Date:  1987-04-17       Impact factor: 47.728

2.  Statistical analysis of Salmonella test data and comparison to results of animal cancer tests.

Authors:  J McCann; L S Gold; L Horn; R McGill; T E Graedel; J Kaldor
Journal:  Mutat Res       Date:  1988 May-Aug       Impact factor: 2.433

3.  Some tautologous aspects of the comparison of carcinogenic potency in rats and mice.

Authors:  L Bernstein; L S Gold; B N Ames; M C Pike; D G Hoel
Journal:  Fundam Appl Toxicol       Date:  1985-02

4.  Relative potency of chemical carcinogens in rodents.

Authors:  D W Gaylor; J J Chen
Journal:  Risk Anal       Date:  1986-09       Impact factor: 4.000

5.  An empirical comparison of methods used to estimate carcinogenic potency in long-term animal bioassays: lifetable vs summary incidence data.

Authors:  L S Gold; L Bernstein; J Kaldor; G Backman; D Hoel
Journal:  Fundam Appl Toxicol       Date:  1986-02

6.  Comparative results of 327 chemical carcinogenicity studies.

Authors:  J K Haseman; J E Huff; E Zeiger; E E McConnell
Journal:  Environ Health Perspect       Date:  1987-10       Impact factor: 9.031

7.  Second chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1984 and by the National Toxicology Program through May 1986.

Authors:  L S Gold; T H Slone; G M Backman; R Magaw; M Da Costa; P Lopipero; M Blumenthal; B N Ames
Journal:  Environ Health Perspect       Date:  1987-10       Impact factor: 9.031

8.  Ranking the potential carcinogenic hazards to workers from exposures to chemicals that are tumorigenic in rodents.

Authors:  L S Gold; G M Backman; N K Hooper; R Peto
Journal:  Environ Health Perspect       Date:  1987-12       Impact factor: 9.031

Review 9.  Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982.

Authors:  L S Gold; M de Veciana; G M Backman; R Magaw; P Lopipero; M Smith; M Blumenthal; R Levinson; L Bernstein; B N Ames
Journal:  Environ Health Perspect       Date:  1986-08       Impact factor: 9.031

10.  A carcinogenic potency database of the standardized results of animal bioassays.

Authors:  L S Gold; C B Sawyer; R Magaw; G M Backman; M de Veciana; R Levinson; N K Hooper; W R Havender; L Bernstein; R Peto
Journal:  Environ Health Perspect       Date:  1984-12       Impact factor: 9.031
  10 in total
  17 in total

1.  Dietary pesticides (99.99% all natural).

Authors:  B N Ames; M Profet; L S Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

2.  Chemical carcinogenesis: too many rodent carcinogens.

Authors:  B N Ames; L S Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

3.  Higher plants as bioindicators of sulphur dioxide emissions in urban environments.

Authors:  Concepción Fidalgo Hijano; Maria Dolores Petit Domínguez; Rosario García Gimínez; Pilar Hungría Sínchez; Inís Sancho García
Journal:  Environ Monit Assess       Date:  2005-12       Impact factor: 2.513

4.  1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies.

Authors:  Mohamed Hagras; Marwa A Saleh; Rogy R Ezz Eldin; Abdelrahman A Abuelkhir; Emad Gamil Khidr; Ahmed A El-Husseiny; Hesham A El-Mahdy; Eslam B Elkaeed; Ibrahim H Eissa
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

5.  A RASH analysis of National Toxicology Program data: predictions for 30 compounds to be tested in rodent carcinogenesis experiments.

Authors:  T D Jones; C E Easterly
Journal:  Environ Health Perspect       Date:  1996-10       Impact factor: 9.031

6.  Toxicological potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin relative to 100 other compounds: a relative potency analysis of in vitro and in vivo test data.

Authors:  T D Jones
Journal:  Arch Environ Contam Toxicol       Date:  1995-07       Impact factor: 2.804

7.  Activation and detection of (pro)mutagenic chemicals using recombinant strains of Streptomyces griseus.

Authors:  S E Buchholz; C A Omer; P V Viitanen; F S Sariaslani; R G Stahl
Journal:  Appl Biochem Biotechnol       Date:  1992 Jan-Mar       Impact factor: 2.926

Review 8.  Sixth plot of the carcinogenic potency database: results of animal bioassays published in the General Literature 1989 to 1990 and by the National Toxicology Program 1990 to 1993.

Authors:  L S Gold; N B Manley; T H Slone; G B Garfinkel; B N Ames; L Rohrbach; B R Stern; K Chow
Journal:  Environ Health Perspect       Date:  1995-11       Impact factor: 9.031

9.  The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989.

Authors:  L S Gold; N B Manley; T H Slone; G B Garfinkel; L Rohrbach; B N Ames
Journal:  Environ Health Perspect       Date:  1993-04       Impact factor: 9.031

10.  Are genotoxic carcinogens more potent than nongenotoxic carcinogens?

Authors:  S Parodi; D Malacarne; P Romano; M Taningher
Journal:  Environ Health Perspect       Date:  1991-11       Impact factor: 9.031
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