Literature DB >> 3691430

Comparative results of 327 chemical carcinogenicity studies.

J K Haseman1, J E Huff, E Zeiger, E E McConnell.   

Abstract

The National Cancer Institute (NCI) and the National Toxicology Program (NTP) have carried out a number of laboratory animal carcinogenicity studies and presented the results of these experiments in a series of Technical Reports. This paper tabulates the results of the 327 NCI/NTP studies carried out to date on 308 distinct chemicals, and discusses certain issues relevant to the evaluation of carcinogenicity in these experiments. This compilation of results from NCI/NTP carcinogenicity experiments provides a large database that can be used to study structure-activity correlations, interspecies concordance, and associations between laboratory animal carcinogenicity and other toxicological effects.

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Year:  1987        PMID： 3691430      PMCID： PMC1474512          DOI： 10.1289/ehp.8774229

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  11 in total

1.  Carcinogenesis studies design and experimental data interpretation/evaluation at the National Toxicology Program.

Authors:  J E Huff; J A Moore
Journal:  Prog Clin Biol Res       Date:  1984

2.  Summary of carcinogenicity data generated by the National Cancer Institute/National Toxicology Program.

Authors:  F J Di Carlo; V A Fung
Journal:  Drug Metab Rev       Date:  1984       Impact factor: 4.518

3.  Toward a classification scheme for degrees of experimental evidence for the carcinogenicity of chemicals for animals.

Authors:  R A Griesemer; C Cueto
Journal:  IARC Sci Publ       Date:  1980

Review 4.  Liver lesions in B6C3F1 mice: the National Toxicology Program, experience and position.

Authors:  R R Maronpot; J K Haseman; G A Boorman; S E Eustis; G N Rao; J E Huff
Journal:  Arch Toxicol Suppl       Date:  1987

5.  The redundancy of mouse carcinogenicity bioassays.

Authors:  M Schach von Wittenau; P C Estes
Journal:  Fundam Appl Toxicol       Date:  1983 Nov-Dec

6.  Factors in the evaluation of 200 National Cancer Institute carcinogen bioassays.

Authors:  K C Chu; C Cueto; J M Ward
Journal:  J Toxicol Environ Health       Date:  1981 Jul-Aug

Review 7.  Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982.

Authors:  L S Gold; M de Veciana; G M Backman; R Magaw; P Lopipero; M Smith; M Blumenthal; R Levinson; L Bernstein; B N Ames
Journal:  Environ Health Perspect       Date:  1986-08       Impact factor: 9.031

8.  Statistical issues in the design, analysis and interpretation of animal carcinogenicity studies.

Authors:  J K Haseman
Journal:  Environ Health Perspect       Date:  1984-12       Impact factor: 9.031

9.  A carcinogenic potency database of the standardized results of animal bioassays.

Authors:  L S Gold; C B Sawyer; R Magaw; G M Backman; M de Veciana; R Levinson; N K Hooper; W R Havender; L Bernstein; R Peto
Journal:  Environ Health Perspect       Date:  1984-12       Impact factor: 9.031

10.  Inter-species comparisons of carcinogenicity.

Authors:  I F Purchase
Journal:  Br J Cancer       Date:  1980-03       Impact factor: 7.640
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  17 in total

1.  Comment: integrating epidemiologic data into risk assessment.

Authors:  D Wartenberg; R Simon
Journal:  Am J Public Health       Date:  1995-04       Impact factor: 9.308

Review 2.  Benzene-induced cancers: abridged history and occupational health impact.

Authors:  James Huff
Journal:  Int J Occup Environ Health       Date:  2007 Apr-Jun

3.  The chemotherapeutic potential of glycol alkyl ethers: structure-activity studies of nine compounds in a Fischer-rat leukemia transplant model.

Authors:  M P Dieter; C W Jameson; R R Maronpot; R Langenbach; A G Braun
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

Review 4.  Occurrence and relevance of chemically induced benign neoplasms in long-term carcinogenicity studies.

Authors:  J E Huff; S L Eustis; J K Haseman
Journal:  Cancer Metastasis Rev       Date:  1989-06       Impact factor: 9.264

5.  Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens.

Authors:  Clifford R Elcombe; Jenny Odum; John R Foster; Susan Stone; Susan Hasmall; Anthony R Soames; Ian Kimber; John Ashby
Journal:  Environ Health Perspect       Date:  2002-04       Impact factor: 9.031

6.  Comparative evaluation of genetic toxicity patterns of carcinogens and noncarcinogens: strategies for predictive use of short-term assays.

Authors:  R W Tennant; J W Spalding; S Stasiewicz; W D Caspary; J M Mason; M A Resnick
Journal:  Environ Health Perspect       Date:  1987-11       Impact factor: 9.031

7.  Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database.

Authors:  L S Gold; T H Slone; L Bernstein
Journal:  Environ Health Perspect       Date:  1989-02       Impact factor: 9.031

Review 8.  Carcinogenesis studies in rodents for evaluating risks associated with chemical carcinogens in aquatic food animals.

Authors:  J Huff; J Bucher; R Yang
Journal:  Environ Health Perspect       Date:  1991-01       Impact factor: 9.031

9.  Correlations between chemically related site-specific carcinogenic effects in long-term studies in rats and mice.

Authors:  J K Haseman; A M Lockhart
Journal:  Environ Health Perspect       Date:  1993-04-22       Impact factor: 9.031

10.  Interspecies extrapolation in carcinogenesis: prediction between rats and mice.

Authors:  L S Gold; L Bernstein; R Magaw; T H Slone
Journal:  Environ Health Perspect       Date:  1989-05       Impact factor: 9.031
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