Literature DB >> 27061491

Roles of Fe-S proteins: from cofactor synthesis to iron homeostasis to protein synthesis.

Debkumar Pain1, Andrew Dancis2.   

Abstract

Fe-S cluster assembly is an essential process for all cells. Impairment of Fe-S cluster assembly creates diseases in diverse and surprising ways. In one scenario, the loss of function of lipoic acid synthase, an enzyme with Fe-S cluster cofactor in mitochondria, impairs activity of various lipoamide-dependent enzymes with drastic consequences for metabolism. In a second scenario, the heme biosynthetic pathway in red cell precursors is specifically targeted, and iron homeostasis is perturbed, but lipoic acid synthesis is unaffected. In a third scenario, tRNA modifications arising from action of the cysteine desulfurase and/or Fe-S cluster proteins are lost, which may lead to impaired protein synthesis. These defects can then result in cancer, neurologic dysfunction or type 2 diabetes.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27061491      PMCID： PMC5055408          DOI： 10.1016/j.gde.2016.03.006

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


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