Literature DB >> 29983374

Architectural Features of Human Mitochondrial Cysteine Desulfurase Complexes from Crosslinking Mass Spectrometry and Small-Angle X-Ray Scattering.

Kai Cai1, Ronnie O Frederick1, Hesam Dashti1, John L Markley2.   

Abstract

Cysteine desulfurase plays a central role in mitochondrial iron-sulfur cluster biogenesis by generating sulfur through the conversion of L-cysteine to L-alanine and by serving as the platform for assembling other components of the biosynthetic machinery, including ISCU, frataxin, and ferredoxin. The human mitochondrial cysteine desulfurase complex consists of two copies each of NFS1, ISD11, and acyl carrier protein. We describe results from chemical crosslinking coupled with tandem mass spectrometry and small-angle X-ray scattering studies that are consistent with a closed NFS1 dimer rather than an open one for both the cysteine desulfurase-ISCU and cysteine desulfurase-ISCU-frataxin complexes. We present a structural model for the cysteine desulfurase-ISCU-frataxin complex derived from chemical crosslinking restraints in conjunction with the recent crystal structure of the cysteine desulfurase-ISCU-zinc complex and distance constraints from nuclear magnetic resonance.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  crosslinking coupled with tandem mass spectrometry (XL-MS); iron-sulfur cluster biosynthesis; small-angle X-ray scattering (SAXS)

Mesh：

Substances：

Year:  2018        PMID： 29983374      PMCID： PMC6082693          DOI： 10.1016/j.str.2018.05.017

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  73 in total

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Journal:  Angew Chem Int Ed Engl       Date:  2012-04-18       Impact factor: 15.336

2.  Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.

Authors:  Seth A Cory; Jonathan G Van Vranken; Edward J Brignole; Shachin Patra; Dennis R Winge; Catherine L Drennan; Jared Rutter; David P Barondeau
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-20       Impact factor: 11.205

Review 3.  Iron-sulfur cluster biogenesis and trafficking in mitochondria.

Authors:  Joseph J Braymer; Roland Lill
Journal:  J Biol Chem       Date:  2017-06-14       Impact factor: 5.157

4.  The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria.

Authors:  Alexander C Adam; Carsten Bornhövd; Holger Prokisch; Walter Neupert; Kai Hell
Journal:  EMBO J       Date:  2005-12-08       Impact factor: 11.598

Review 5.  Emerging applications of small angle solution scattering in structural biology.

Authors:  Barnali N Chaudhuri
Journal:  Protein Sci       Date:  2015-02-12       Impact factor: 6.725

Review 6.  Iron-sulfur-protein biogenesis in eukaryotes.

Authors:  Roland Lill; Ulrich Mühlenhoff
Journal:  Trends Biochem Sci       Date:  2005-03       Impact factor: 13.807

7.  Crystal structure of IscS, a cysteine desulfurase from Escherichia coli.

Authors:  Jill R Cupp-Vickery; Hugo Urbina; Larry E Vickery
Journal:  J Mol Biol       Date:  2003-07-25       Impact factor: 5.469

8.  Down-regulation of mitochondrial acyl carrier protein in mammalian cells compromises protein lipoylation and respiratory complex I and results in cell death.

Authors:  Dejiang Feng; Andrzej Witkowski; Stuart Smith
Journal:  J Biol Chem       Date:  2009-02-16       Impact factor: 5.157

9.  Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis.

Authors:  Kai Cai; Marco Tonelli; Ronnie O Frederick; John L Markley
Journal:  Biochemistry       Date:  2017-01-11       Impact factor: 3.162

10.  Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly.

Authors:  Kai Cai; Ronnie O Frederick; Marco Tonelli; John L Markley
Journal:  J Inorg Biochem       Date:  2018-03-15       Impact factor: 4.155
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  5 in total

Review 1.  Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis.

Authors:  Nunziata Maio; Tracey A Rouault
Journal:  Trends Biochem Sci       Date:  2020-03-06       Impact factor: 13.807

2.  Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.

Authors:  Nicholas G Fox; Xiaodi Yu; Xidong Feng; Henry J Bailey; Alain Martelli; Joseph F Nabhan; Claire Strain-Damerell; Christine Bulawa; Wyatt W Yue; Seungil Han
Journal:  Nat Commun       Date:  2019-05-17       Impact factor: 14.919

3.  Archiving and disseminating integrative structure models.

Authors:  Brinda Vallat; Benjamin Webb; John Westbrook; Andrej Sali; Helen M Berman
Journal:  J Biomol NMR       Date:  2019-07-05       Impact factor: 2.835

4.  Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures.

Authors:  Helen M Berman; Paul D Adams; Alexandre A Bonvin; Stephen K Burley; Bridget Carragher; Wah Chiu; Frank DiMaio; Thomas E Ferrin; Margaret J Gabanyi; Thomas D Goddard; Patrick R Griffin; Juergen Haas; Christian A Hanke; Jeffrey C Hoch; Gerhard Hummer; Genji Kurisu; Catherine L Lawson; Alexander Leitner; John L Markley; Jens Meiler; Gaetano T Montelione; George N Phillips; Thomas Prisner; Juri Rappsilber; David C Schriemer; Torsten Schwede; Claus A M Seidel; Timothy S Strutzenberg; Dmitri I Svergun; Emad Tajkhorshid; Jill Trewhella; Brinda Vallat; Sameer Velankar; Geerten W Vuister; Benjamin Webb; John D Westbrook; Kate L White; Andrej Sali
Journal:  Structure       Date:  2019-11-25       Impact factor: 5.006

Review 5.  NMR as a Tool to Investigate the Processes of Mitochondrial and Cytosolic Iron-Sulfur Cluster Biosynthesis.

Authors:  Kai Cai; John L Markley
Journal:  Molecules       Date:  2018-08-31       Impact factor: 4.411
  5 in total

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