Literature DB >> 26997457

Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.

Qiuyan Shi1, Yu Li, Shaowei Bo, Xiaofei Li, Peng Zhao, Qi Liu, Zhigang Yang, Hengjiang Cong, Hexiang Deng, Mingnan Chen, Shizhen Chen, Xin Zhou, Hong Ding, Zhong-Xing Jiang.   

Abstract

Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. To improve its potency and selectivity, an analog library of salinomycin was generated by site-specific modification and CuAAc derivatization. Through a cytotoxicity analysis of the library, a fluorinated analog with high potency, selectivity, and (19)F MRI sensitivity was discovered as a novel theranostic agent.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 26997457      PMCID： PMC5271582          DOI： 10.1039/c6cc01508e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  24 in total

1.  Salinomycin inhibits osteosarcoma by targeting its tumor stem cells.

Authors:  Qing-Lian Tang; Zhi-Qiang Zhao; Jin-Chun Li; Yi Liang; Jun-Qiang Yin; Chang-Ye Zou; Xian-Biao Xie; Yi-Xin Zeng; Jing-Nan Shen; Tiebang Kang; Jin Wang
Journal:  Cancer Lett       Date:  2011-07-21       Impact factor: 8.679

2.  Paramagnetic relaxation-based 19f MRI probe to detect protease activity.

Authors:  Shin Mizukami; Rika Takikawa; Fuminori Sugihara; Yuichiro Hori; Hidehito Tochio; Markus Wälchli; Masahiro Shirakawa; Kazuya Kikuchi
Journal:  J Am Chem Soc       Date:  2007-12-23       Impact factor: 15.419

3.  Semisynthesis of SY-1 for investigation of breast cancer stem cell selectivity of C-ring-modified salinomycin analogues.

Authors:  Xiaoli Huang; Björn Borgström; Linda Månsson; Lo Persson; Stina Oredsson; Cecilia Hegardt; Daniel Strand
Journal:  ACS Chem Biol       Date:  2014-05-29       Impact factor: 5.100

4.  Anticoccidial activity of salinomycin derivatives.

Authors:  P Hammann; W Raether; L Vertesy
Journal:  J Antibiot (Tokyo)       Date:  1993-03       Impact factor: 2.649

5.  Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.

Authors:  Michał Antoszczak; Maria Sobusiak; Ewa Maj; Joanna Wietrzyk; Adam Huczyński
Journal:  Bioorg Med Chem Lett       Date:  2015-07-02       Impact factor: 2.823

Review 6.  Polyether ionophores-promising bioactive molecules for cancer therapy.

Authors:  Adam Huczyński
Journal:  Bioorg Med Chem Lett       Date:  2012-09-23       Impact factor: 2.823

7.  Antiproliferative activity of salinomycin and its derivatives.

Authors:  Adam Huczyński; Jan Janczak; Michał Antoszczak; Joanna Wietrzyk; Ewa Maj; Bogumil Brzezinski
Journal:  Bioorg Med Chem Lett       Date:  2012-09-27       Impact factor: 2.823

8.  Synthetic modification of salinomycin: selective O-acylation and biological evaluation.

Authors:  Björn Borgström; Xiaoli Huang; Martin Pošta; Cecilia Hegardt; Stina Oredsson; Daniel Strand
Journal:  Chem Commun (Camb)       Date:  2013-11-04       Impact factor: 6.222

9.  Synthesis, anticancer and antibacterial activity of salinomycin N-benzyl amides.

Authors:  Michał Antoszczak; Ewa Maj; Agnieszka Napiórkowska; Joanna Stefańska; Ewa Augustynowicz-Kopeć; Joanna Wietrzyk; Jan Janczak; Bogumil Brzezinski; Adam Huczyński
Journal:  Molecules       Date:  2014-11-25       Impact factor: 4.411

10.  iTEP nanoparticle-delivered salinomycin displays an enhanced toxicity to cancer stem cells in orthotopic breast tumors.

Authors:  Peng Zhao; Shuyun Dong; Jayanta Bhattacharyya; Mingnan Chen
Journal:  Mol Pharm       Date:  2014-07-01       Impact factor: 4.939
View more
  7 in total

1.  Expeditive Synthesis of Potent C20-epi-Amino Derivatives of Salinomycin against Cancer Stem-Like Cells.

Authors:  Dominika Czerwonka; Sebastian Müller; Tatiana Cañeque; Ludovic Colombeau; Adam Huczyński; Michał Antoszczak; Raphaël Rodriguez
Journal:  ACS Org Inorg Au       Date:  2022-01-05

2.  Rapid Access to Ironomycin Derivatives by Click Chemistry.

Authors:  Michał Antoszczak; Sebastian Müller; Ludovic Colombeau; Tatiana Cañeque; Raphaël Rodriguez
Journal:  ACS Org Inorg Au       Date:  2022-01-21

3.  Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.

Authors:  Yu Li; Guiquan Xia; Qi Guo; Li Wu; Shizhen Chen; Zhigang Yang; Wei Wang; Zhong-Yin Zhang; Xin Zhou; Zhong-Xing Jiang
Journal:  Medchemcomm       Date:  2016-06-20       Impact factor: 3.597

4.  Salinomycin kills cancer stem cells by sequestering iron in lysosomes.

Authors:  Trang Thi Mai; Ahmed Hamaï; Antje Hienzsch; Tatiana Cañeque; Sebastian Müller; Julien Wicinski; Olivier Cabaud; Christine Leroy; Amandine David; Verónica Acevedo; Akihide Ryo; Christophe Ginestier; Daniel Birnbaum; Emmanuelle Charafe-Jauffret; Patrice Codogno; Maryam Mehrpour; Raphaël Rodriguez
Journal:  Nat Chem       Date:  2017-05-16       Impact factor: 24.427

5.  Synthesis and Anticancer Activity of Dimeric Polyether Ionophores.

Authors:  Michał Sulik; Ewa Maj; Joanna Wietrzyk; Adam Huczyński; Michał Antoszczak
Journal:  Biomolecules       Date:  2020-07-12

Review 6.  Salinomycin as a potent anticancer stem cell agent: State of the art and future directions.

Authors:  Dan Qi; Yunyi Liu; Juan Li; Jason H Huang; Xiaoxiao Hu; Erxi Wu
Journal:  Med Res Rev       Date:  2021-11-16       Impact factor: 12.388

7.  Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models.

Authors:  Alicja Urbaniak; Megan R Reed; Daniel Fil; Anika Moorjani; Sarah Heflin; Michał Antoszczak; Michał Sulik; Adam Huczyński; Michalina Kupsik; Robert L Eoff; Melanie C MacNicol; Timothy C Chambers; Angus M MacNicol
Journal:  Biomed Pharmacother       Date:  2021-06-12       Impact factor: 7.419
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.