Literature DB >> 27529021

Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.

Yu Li1, Guiquan Xia1, Qi Guo1, Li Wu2, Shizhen Chen3, Zhigang Yang1, Wei Wang1, Zhong-Yin Zhang2, Xin Zhou3, Zhong-Xing Jiang4.   

Abstract

Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatases (PTPs)-targeted drug discovery and imaging-guided PTP research with fluorine, several highly potent and 19F MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.

Entities:  

Year:  2016        PMID： 27529021      PMCID： PMC4982551          DOI： 10.1039/C6MD00277C

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  19 in total

Review 1.  Protein tyrosine phosphatases: prospects for therapeutics.

Authors:  Z Y Zhang
Journal:  Curr Opin Chem Biol       Date:  2001-08       Impact factor: 8.822

Review 2.  Tyrosine kinases as targets for cancer therapy.

Authors:  Daniela S Krause; Richard A Van Etten
Journal:  N Engl J Med       Date:  2005-07-14       Impact factor: 91.245

Review 3.  Protein tyrosine phosphatases: from genes, to function, to disease.

Authors:  Nicholas K Tonks
Journal:  Nat Rev Mol Cell Biol       Date:  2006-11       Impact factor: 94.444

4.  Paramagnetic relaxation-based 19f MRI probe to detect protease activity.

Authors:  Shin Mizukami; Rika Takikawa; Fuminori Sugihara; Yuichiro Hori; Hidehito Tochio; Markus Wälchli; Masahiro Shirakawa; Kazuya Kikuchi
Journal:  J Am Chem Soc       Date:  2007-12-23       Impact factor: 15.419

Review 5.  Inhibitors of protein tyrosine phosphatases: next-generation drugs?

Authors:  Laurent Bialy; Herbert Waldmann
Journal:  Angew Chem Int Ed Engl       Date:  2005-06-20       Impact factor: 15.336

6.  Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.

Authors:  Y A Puius; Y Zhao; M Sullivan; D S Lawrence; S C Almo; Z Y Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

7.  Design and Synthesis of Fluorinated Amphiphile as (19)F MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly.

Authors:  Shaowei Bo; Cong Song; Yu Li; Weijiang Yu; Shizhen Chen; Xin Zhou; Zhigang Yang; Xing Zheng; Zhong-Xing Jiang
Journal:  J Org Chem       Date:  2015-06-05       Impact factor: 4.354

8.  Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.

Authors:  Qiuyan Shi; Yu Li; Shaowei Bo; Xiaofei Li; Peng Zhao; Qi Liu; Zhigang Yang; Hengjiang Cong; Hexiang Deng; Mingnan Chen; Shizhen Chen; Xin Zhou; Hong Ding; Zhong-Xing Jiang
Journal:  Chem Commun (Camb)       Date:  2016-03-21       Impact factor: 6.222

9.  Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.

Authors:  Xiao Yu; Jin-Peng Sun; Yantao He; Xiaoling Guo; Sijiu Liu; Bo Zhou; Andy Hudmon; Zhong-Yin Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-03       Impact factor: 11.205

10.  Therapeutic potential of targeting the oncogenic SHP2 phosphatase.

Authors:  Li-Fan Zeng; Ruo-Yu Zhang; Zhi-Hong Yu; Sijiu Li; Li Wu; Andrea M Gunawan; Brandon S Lane; Raghuveer S Mali; Xingjun Li; Rebecca J Chan; Reuben Kapur; Clark D Wells; Zhong-Yin Zhang
Journal:  J Med Chem       Date:  2014-07-28       Impact factor: 7.446
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  1 in total

1.  Selective Nuclear Magnetic Resonance Experiments for Sign-Sensitive Determination of Heteronuclear Couplings: Expanding the Analysis of Crude Reaction Mixtures.

Authors:  Guilherme Dal Poggetto; João Vitor Soares; Cláudio F Tormena
Journal:  Anal Chem       Date:  2020-09-28       Impact factor: 6.986
  1 in total

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