Literature DB >> 26163197

Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.

Michał Antoszczak1, Maria Sobusiak1, Ewa Maj2, Joanna Wietrzyk2, Adam Huczyński3.   

Abstract

New Salinomycin (SAL) bioconjugates with amino acid methyl esters were obtained and their antiproliferative activity against cancer cell lines including drug-resistant ones was studied. New compounds exhibit antiproliferative activity towards leukemia and doxorubicin-resistant colon adenocarcinoma cell line and are more effective and less toxic than the commonly currently used anticancer drugs.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Amino acid derivatives; Anticancer activity; Doxorubicin-resistant cells; Salinomycin bioconjugates

Mesh：

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Year:  2015        PMID： 26163197     DOI： 10.1016/j.bmcl.2015.06.086

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.

Authors:  Qiuyan Shi; Yu Li; Shaowei Bo; Xiaofei Li; Peng Zhao; Qi Liu; Zhigang Yang; Hengjiang Cong; Hexiang Deng; Mingnan Chen; Shizhen Chen; Xin Zhou; Hong Ding; Zhong-Xing Jiang
Journal:  Chem Commun (Camb)       Date:  2016-03-21       Impact factor: 6.222

2.  Synthesis of Lasalocid-Based Bioconjugates and Evaluation of Their Anticancer Activity.

Authors:  Michał Antoszczak; Dagmara Otto-Ślusarczyk; Marta Kordylas; Marta Struga; Adam Huczyński
Journal:  ACS Omega       Date:  2022-01-07

Review 3.  Salinomycin as a potent anticancer stem cell agent: State of the art and future directions.

Authors:  Dan Qi; Yunyi Liu; Juan Li; Jason H Huang; Xiaoxiao Hu; Erxi Wu
Journal:  Med Res Rev       Date:  2021-11-16       Impact factor: 12.388
  3 in total

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