Literature DB >> 23079523

Antiproliferative activity of salinomycin and its derivatives.

Adam Huczyński1, Jan Janczak, Michał Antoszczak, Joanna Wietrzyk, Ewa Maj, Bogumil Brzezinski.   

Abstract

Antiproliferative activity of seven amides and one benzotriazole ester derivative of salinomycin, a polyether ionophore antibiotic, with recently reported antibacterial activity, are herein described. Salinomycin and the majority of derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines. Moreover almost all derivatives show stronger activity against LoVo/DX cell line than that of unmodified salinomycin.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23079523     DOI： 10.1016/j.bmcl.2012.09.068

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  18 in total

1.  Effects of iron modulation on mesenchymal stem cell-induced drug resistance in estrogen receptor-positive breast cancer.

Authors:  Johanna M Buschhaus; Shrila Rajendran; Brock A Humphries; Alyssa C Cutter; Ayşe J Muñiz; Nicholas G Ciavattone; Alexander M Buschhaus; Tatiana Cañeque; Zeribe C Nwosu; Debashis Sahoo; Avinash S Bevoor; Yatrik M Shah; Costas A Lyssiotis; Pradipta Ghosh; Max S Wicha; Raphaël Rodriguez; Gary D Luker
Journal:  Oncogene       Date:  2022-06-22       Impact factor: 8.756

Review 2.  The complex relationship between multiple drug resistance and the tumor pH gradient: a review.

Authors:  Tomas Koltai
Journal:  Cancer Drug Resist       Date:  2022-04-03

3.  Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.

Authors:  Qiuyan Shi; Yu Li; Shaowei Bo; Xiaofei Li; Peng Zhao; Qi Liu; Zhigang Yang; Hengjiang Cong; Hexiang Deng; Mingnan Chen; Shizhen Chen; Xin Zhou; Hong Ding; Zhong-Xing Jiang
Journal:  Chem Commun (Camb)       Date:  2016-03-21       Impact factor: 6.222

Review 4.  Salinomycin: a novel anti-cancer agent with known anti-coccidial activities.

Authors:  Shuang Zhou; Fengfei Wang; Eric T Wong; Ekokobe Fonkem; Tze-Chen Hsieh; Joseph M Wu; Erxi Wu
Journal:  Curr Med Chem       Date:  2013       Impact factor: 4.530

5.  Salinomycin kills cancer stem cells by sequestering iron in lysosomes.

Authors:  Trang Thi Mai; Ahmed Hamaï; Antje Hienzsch; Tatiana Cañeque; Sebastian Müller; Julien Wicinski; Olivier Cabaud; Christine Leroy; Amandine David; Verónica Acevedo; Akihide Ryo; Christophe Ginestier; Daniel Birnbaum; Emmanuelle Charafe-Jauffret; Patrice Codogno; Maryam Mehrpour; Raphaël Rodriguez
Journal:  Nat Chem       Date:  2017-05-16       Impact factor: 24.427

6.  Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling.

Authors:  Jianyong Yu; Yang Yang; Shan Li; Peng Meng
Journal:  Exp Ther Med       Date:  2021-07-01       Impact factor: 2.447

7.  Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs.

Authors:  Xiaoli Huang; Björn Borgström; Sebastian Kempengren; Lo Persson; Cecilia Hegardt; Daniel Strand; Stina Oredsson
Journal:  BMC Cancer       Date:  2016-02-23       Impact factor: 4.430

8.  Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling.

Authors:  Dietmar Steverding; Darren W Sexton
Journal:  Parasit Vectors       Date:  2013-03-21       Impact factor: 3.876

9.  Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice.

Authors:  Olajumoke Omolara Ojo; Smrati Bhadauria; Srikanta Kumar Rath
Journal:  PLoS One       Date:  2013-07-01       Impact factor: 3.240

Review 10.  A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers.

Authors:  Kamal Ahmed; Holly V Shaw; Alexey Koval; Vladimir L Katanaev
Journal:  Cancers (Basel)       Date:  2016-07-14       Impact factor: 6.639
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