Yukihisa Takayama1, Akihiro Nishie2, Masaaki Sugimoto3,4, Osamu Togao5, Yoshiki Asayama5, Kousei Ishigami5, Yasuhiro Ushijima5, Daisuke Okamoto5, Nobuhiro Fujita5, Akira Yokomizo4, Jochen Keupp6, Hiroshi Honda5. 1. Department of Radiology Informatics and Network, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 8128582, Japan. 2. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 8128582, Japan. anishie@radiol.med.kyushu-u.ac.jp. 3. Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 8128582, Japan. 4. Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 8128582, Japan. 5. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 8128582, Japan. 6. Philips Research, Roentgenstr. 24-26, 22335, Hamburg, Germany.
Abstract
OBJECTIVE: To evaluate the utility of amide proton transfer (APT) imaging in estimating the Gleason score (GS) of prostate cancer (Pca). MATERIALS AND METHODS: Sixty-six biopsy-proven cancers were categorized into four groups according to the GS: GS-6 (3 + 3); GS-7 (3 + 4/4 + 3); GS-8 (4 + 4) and GS-9 (4 + 5/5 + 4). APT signal intensities (APT SIs) and apparent diffusion coefficient (ADC) values of each GS group were compared by one-way analysis of variance with Tukey's HSD post hoc test. RESULTS: The mean and standard deviation of the APT SIs (%) and ADC values (×10(-3) mm(2)/s) were as follows: GS-6, 2.48 ± 0.59 and 1.16 ± 0.26; GS-7, 5.17 ± 0.66 and 0.92 ± 0.18; GS-8, 2.56 ± 0.85 and 0.86 ± 0.17; GS-9, 1.96 ± 0.75 and 0.85 ± 0.18, respectively. The APT SI of the GS-7 group was highest, and there were significant differences between the GS-6 and GS-7 groups and the GS-7 and GS-9 groups (p < 0.05). The ADC value of the GS-6 group was significantly higher than each value of the GS-7, GS-8, and GS-9 groups (p < 0.05), but no significant differences were obtained among the GS-7, GS-8, and GS-9 groups. CONCLUSION: The mean APT SI in Pca with a GS of 7 was higher than that for the other GS groups.
OBJECTIVE: To evaluate the utility of amide proton transfer (APT) imaging in estimating the Gleason score (GS) of prostate cancer (Pca). MATERIALS AND METHODS: Sixty-six biopsy-proven cancers were categorized into four groups according to the GS: GS-6 (3 + 3); GS-7 (3 + 4/4 + 3); GS-8 (4 + 4) and GS-9 (4 + 5/5 + 4). APT signal intensities (APT SIs) and apparent diffusion coefficient (ADC) values of each GS group were compared by one-way analysis of variance with Tukey's HSD post hoc test. RESULTS: The mean and standard deviation of the APT SIs (%) and ADC values (×10(-3) mm(2)/s) were as follows: GS-6, 2.48 ± 0.59 and 1.16 ± 0.26; GS-7, 5.17 ± 0.66 and 0.92 ± 0.18; GS-8, 2.56 ± 0.85 and 0.86 ± 0.17; GS-9, 1.96 ± 0.75 and 0.85 ± 0.18, respectively. The APT SI of the GS-7 group was highest, and there were significant differences between the GS-6 and GS-7 groups and the GS-7 and GS-9 groups (p < 0.05). The ADC value of the GS-6 group was significantly higher than each value of the GS-7, GS-8, and GS-9 groups (p < 0.05), but no significant differences were obtained among the GS-7, GS-8, and GS-9 groups. CONCLUSION: The mean APT SI in Pca with a GS of 7 was higher than that for the other GS groups.
Authors: Stephen J Freedland; Christopher J Kane; Christopher L Amling; William J Aronson; Martha K Terris; Joseph C Presti Journal: Urology Date: 2007-03 Impact factor: 2.649
Authors: Adrienne N Dula; Lori R Arlinghaus; Richard D Dortch; Blake E Dewey; Jennifer G Whisenant; Gregory D Ayers; Thomas E Yankeelov; Seth A Smith Journal: Magn Reson Med Date: 2012-08-20 Impact factor: 4.668
Authors: Rajakumar Nagarajan; Daniel Margolis; Steven Raman; Manoj K Sarma; Ke Sheng; Christopher R King; Gaurav Verma; James Sayre; Robert E Reiter; M Albert Thomas Journal: J Magn Reson Imaging Date: 2012-05-11 Impact factor: 4.813
Authors: Tristan Barrett; Mary McLean; Andrew N Priest; Edward M Lawrence; Andrew J Patterson; Brendan C Koo; Ilse Patterson; Anne Y Warren; Andrew Doble; Vincent J Gnanapragasam; Christof Kastner; Ferdia A Gallagher Journal: Eur Radiol Date: 2017-12-08 Impact factor: 5.315