Literature DB >> 26956795

Synthesis of the phorboxazoles-potent, architecturally novel marine natural products.

Zachary Shultz1, James W Leahy1,2,3.   

Abstract

The phorboxazoles have attracted the attention of synthetic chemists around the globe due to their potent biological activity and novel structure. A review of the recent synthetic efforts as well as new phorboxazole analogs is discussed.

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Year:  2016        PMID： 26956795     DOI： 10.1038/ja.2016.8

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  32 in total

1.  Total synthesis of phorboxazole A via de novo oxazole formation: strategy and component assembly.

Authors:  Bo Wang; T Matthew Hansen; Ting Wang; Dimao Wu; Lynn Weyer; Lu Ying; Mary M Engler; Melissa Sanville; Christopher Leitheiser; Mathias Christmann; Yingtao Lu; Jiehao Chen; Nicholas Zunker; Russell D Cink; Feryan Ahmed; Chi-Sing Lee; Craig J Forsyth
Journal:  J Am Chem Soc       Date:  2010-12-29       Impact factor: 15.419

2.  Total synthesis of phorboxazole B.

Authors:  Brian S Lucas; Vijayagopal Gopalsamuthiram; Steven D Burke
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336

3.  A second-generation total synthesis of (+)-phorboxazole A.

Authors:  Amos B Smith; Thomas M Razler; Jeffrey P Ciavarri; Tomoyasu Hirose; Tomoyasu Ishikawa; Regina M Meis
Journal:  J Org Chem       Date:  2008-01-24       Impact factor: 4.354

4.  Structure elucidation at the nanomole scale. 2. Hemi-phorboxazole A from Phorbas sp.

Authors:  Doralyn S Dalisay; Tadeusz F Molinski
Journal:  Org Lett       Date:  2009-05-07       Impact factor: 6.005

5.  Design and total synthesis of a fluorescent phorboxazole A analog for cellular studies.

Authors:  Jiehao Chen; Lu Ying; T Matthew Hansen; Mary M Engler; Chi Sing Lee; James J La Clair; Craig J Forsyth
Journal:  Bioorg Med Chem Lett       Date:  2005-11-21       Impact factor: 2.823

6.  The asymmetric Maitland-Japp reaction and its application to the construction of the C1-C19 bis-pyran unit of phorboxazole B.

Authors:  Paul A Clarke; Soraia Santos; Nimesh Mistry; Laurence Burroughs; Alexander C Humphries
Journal:  Org Lett       Date:  2011-01-19       Impact factor: 6.005

7.  Formal [4+2]-annulation of chiral crotylsilanes: synthesis of the C19-C28 fragment of phorboxazoles.

Authors:  H Huang; J S Panek
Journal:  Org Lett       Date:  2001-05-31       Impact factor: 6.005

8.  Asymmetric synthesis of the tetrahydropyran ring, C32-C38 fragment, of phorboxazoles.

Authors:  Yasmin Brinkmann; M Carmen Carreño; Antonio Urbano; Françoise Colobert; Guy Solladié
Journal:  Org Lett       Date:  2004-11-11       Impact factor: 6.005

9.  Hemi-phorboxazole a: structure confirmation, analogue design and biological evaluation.

Authors:  Amos B Smith; Zhuqing Liu; Anne-Marie L Hogan; Doralyn S Dalisay; Tadeusz F Molinski
Journal:  Org Lett       Date:  2009-08-20       Impact factor: 6.005

10.  Gram-scale synthesis of (+)-spongistatin 1: development of an improved, scalable synthesis of the F-ring subunit, fragment union, and final elaboration.

Authors:  Amos B Smith; Takashi Tomioka; Christina A Risatti; Jeffrey B Sperry; Chris Sfouggatakis
Journal:  Org Lett       Date:  2008-08-28       Impact factor: 6.005
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