| Literature DB >> 11405688 |
Abstract
A stereoselective synthesis of the C19-C28 fragment of phoborxazole A and B is described. The key step is an enantioselective [4 + 2]-annulation of a crotylsilane 10 with a propargylic aldehyde 11 affording a functionalized dihydropyran 12. A solvent-dependent stereoselective epoxidation of dihydropyrans is also documented.Entities:
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Year: 2001 PMID： 11405688 DOI： 10.1021/ol015893u
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005