A Suppa1, Y-Z Huang2, K Funke3, M C Ridding4, B Cheeran5, V Di Lazzaro6, U Ziemann7, J C Rothwell8. 1. Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy; Neuromed Institute, IRCCS Pozzilli (IS), Rome, Italy. Electronic address: antonio.suppa@uniroma1.it. 2. Department of Neurology, Neuroscience Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. 3. Department of Neurophysiology, Medical Faculty, Ruhr-University Bochum, Bochum, Germany. 4. The Robinson Research Institute, School of Medicine, The University of Adelaide, Adelaide, Australia. 5. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. 6. Institute of Neurology, Campus Biomedico University, Rome, Italy; Fondazione Alberto Sordi - Research Institute for Ageing, Rome, Italy. 7. Department of Neurology & Stroke, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. 8. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, UK.
Abstract
BACKGROUND/ OBJECTIVES: Over the last ten years, an increasing number of authors have used the theta burst stimulation (TBS) protocol to investigate long-term potentiation (LTP) and long-term depression (LTD)-like plasticity non-invasively in the primary motor cortex (M1) in healthy humans and in patients with various types of movement disorders. We here provide a comprehensive review of the LTP/LTD-like plasticity induced by TBS in the human M1. METHODS: A workgroup of researchers expert in this research field review and discuss critically ten years of experimental evidence from TBS studies in humans and in animal models. The review also includes the discussion of studies assessing responses to TBS in patients with movement disorders. MAIN FINDINGS/DISCUSSION: We discuss experimental studies applying TBS over the M1 or in other cortical regions functionally connected to M1 in healthy subjects and in patients with various types of movement disorders. We also review experimental evidence coming from TBS studies in animals. Finally, we clarify the status of TBS as a possible new non-invasive therapy aimed at improving symptoms in various neurological disorders.
BACKGROUND/ OBJECTIVES: Over the last ten years, an increasing number of authors have used the theta burst stimulation (TBS) protocol to investigate long-term potentiation (LTP) and long-term depression (LTD)-like plasticity non-invasively in the primary motor cortex (M1) in healthy humans and in patients with various types of movement disorders. We here provide a comprehensive review of the LTP/LTD-like plasticity induced by TBS in the human M1. METHODS: A workgroup of researchers expert in this research field review and discuss critically ten years of experimental evidence from TBS studies in humans and in animal models. The review also includes the discussion of studies assessing responses to TBS in patients with movement disorders. MAIN FINDINGS/DISCUSSION: We discuss experimental studies applying TBS over the M1 or in other cortical regions functionally connected to M1 in healthy subjects and in patients with various types of movement disorders. We also review experimental evidence coming from TBS studies in animals. Finally, we clarify the status of TBS as a possible new non-invasive therapy aimed at improving symptoms in various neurological disorders.
Authors: S Notzon; N Vennewald; A Gajewska; A L Klahn; J Diemer; B Winter; I Fohrbeck; V Arolt; P Pauli; K Domschke; P Zwanzger Journal: Eur Arch Psychiatry Clin Neurosci Date: 2017-03-24 Impact factor: 5.270
Authors: L Marsili; A Suppa; F Di Stasio; D Belvisi; N Upadhyay; I Berardelli; M Pasquini; S Petrucci; M Ginevrino; G Fabbrini; F Cardona; G Defazio; A Berardelli Journal: Exp Brain Res Date: 2016-11-30 Impact factor: 1.972
Authors: Daniel T Corp; Hannah G K Bereznicki; Gillian M Clark; George J Youssef; Peter J Fried; Ali Jannati; Charlotte B Davies; Joyce Gomes-Osman; Julie Stamm; Sung Wook Chung; Steven J Bowe; Nigel C Rogasch; Paul B Fitzgerald; Giacomo Koch; Vincenzo Di Lazzaro; Alvaro Pascual-Leone; Peter G Enticott Journal: Brain Stimul Date: 2020-08-03 Impact factor: 8.955