Chin-Song Lu1,2,3, Shu-Hang Ng4,5, Yi-Hsin Weng1,2,3, Jur-Shan Cheng6, Wey-Yil Lin1,2,3, Yau-Yau Wai7, Yao-Liang Chen4,7, Jiun-Jie Wang8,9,10,11. 1. Division of Movement Disorders,Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 2. Neuroscience Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 3. School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan. 4. Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taiwan. 5. Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 WenHua 1st Road, Taoyuan County, 333, Taiwan. 6. Clinical Informatics and Medical Statistics Research Center,College of Medicine, Chang Gung University, Taoyuan, Taiwan. 7. Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Keelung, Taiwan. 8. Neuroscience Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan. jwang@mail.cgu.edu.tw. 9. Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taiwan. jwang@mail.cgu.edu.tw. 10. Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 WenHua 1st Road, Taoyuan County, 333, Taiwan. jwang@mail.cgu.edu.tw. 11. Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University / Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. jwang@mail.cgu.edu.tw.
Abstract
OBJECTIVES: To investigate the diagnostic performance of diffusion tensor imaging in patients with Parkinson's disease (PD). METHODS: We examined a total of 126 PD patients (68 males/58 females, mean age: 62.0 ±7.6 years) and 91 healthy controls (43 males/48 females, mean age: 59.8 ±7.2 years). Images were acquired on a 3 Tesla magnetic resonance scanner. The Camino software was used to normalize and parcellate diffusion-weighted images into 90 cerebral regions based on the automatic anatomical labelling template. The minimum, median, and maximum values of the mean/radial/axial diffusivity/fractional anisotropy were determined. The diagnostic performance was assessed by receiver operating characteristic analysis. The associations of imaging parameters with disease severity were tested using Pearson's correlation coefficients after adjustment for disease duration. RESULTS: Compared with healthy controls, PD patients showed increased diffusivity in multiple cortical regions that extended beyond the basal ganglia. An area under curve of 85 % was identified for the maximum values of mean diffusivity in the ipsilateral middle temporal gyrus. The most significant intergroup difference was 26.8 % for the ipsilateral inferior parietal gyrus. CONCLUSION: The measurement of water diffusion from the parcellated cortex may be clinically useful for the assessment of PD patients. KEY POINTS: • Increased diffusivity was identified in multiple cortical regions of Parkinson's disease patients. • The area under the receiver operating curve was 85 % in the middle temporal gyrus. • The ipsilateral inferior parietal gyrus showed the most significant change.
OBJECTIVES: To investigate the diagnostic performance of diffusion tensor imaging in patients with Parkinson's disease (PD). METHODS: We examined a total of 126 PDpatients (68 males/58 females, mean age: 62.0 ±7.6 years) and 91 healthy controls (43 males/48 females, mean age: 59.8 ±7.2 years). Images were acquired on a 3 Tesla magnetic resonance scanner. The Camino software was used to normalize and parcellate diffusion-weighted images into 90 cerebral regions based on the automatic anatomical labelling template. The minimum, median, and maximum values of the mean/radial/axial diffusivity/fractional anisotropy were determined. The diagnostic performance was assessed by receiver operating characteristic analysis. The associations of imaging parameters with disease severity were tested using Pearson's correlation coefficients after adjustment for disease duration. RESULTS: Compared with healthy controls, PDpatients showed increased diffusivity in multiple cortical regions that extended beyond the basal ganglia. An area under curve of 85 % was identified for the maximum values of mean diffusivity in the ipsilateral middle temporal gyrus. The most significant intergroup difference was 26.8 % for the ipsilateral inferior parietal gyrus. CONCLUSION: The measurement of water diffusion from the parcellated cortex may be clinically useful for the assessment of PDpatients. KEY POINTS: • Increased diffusivity was identified in multiple cortical regions of Parkinson's diseasepatients. • The area under the receiver operating curve was 85 % in the middle temporal gyrus. • The ipsilateral inferior parietal gyrus showed the most significant change.
Authors: G Gattellaro; L Minati; M Grisoli; C Mariani; F Carella; M Osio; E Ciceri; A Albanese; M G Bruzzone Journal: AJNR Am J Neuroradiol Date: 2009-04-02 Impact factor: 3.825
Authors: L-L Chan; H Rumpel; K Yap; E Lee; H-V Loo; G-L Ho; S Fook-Chong; Y Yuen; E-K Tan Journal: J Neurol Neurosurg Psychiatry Date: 2007-07-05 Impact factor: 10.154