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Literature DB >> 269433

Binding of mouse interferon to polynucleotides.

J De Maeyer-Guignard, M N Thang, E De Maeyer.

Abstract

The polynucleotides poly(I) and poly(U), and to a lesser extent poly(G), are capable of desorbing mouse interferon from blue dextran-Sepharose columns, whereas poly(A) andpoly(C) are without effect. When covalently bound to agarose, poly(I), poly(U), and also poly(A) act as potent ligands for purification of interferon by affinity chromatography. Furthermore, poly(I) and poly(U) confer a significant degree of protection to interferon against thermal denaturation. Taken together, these observations point to a direct interaction of interferon with these polymers and suggest that interferon molecules have a polynucleotide attachment site. Possible implications for the concept of interferon induction are discussed.

Entities: Chemical Species

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Year: 1977 PMID： 269433 PMCID： PMC431731 DOI： 10.1073/pnas.74.9.3787

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

12 in total

1. Affinity of human fibroblast interferon for blue dextran.

Authors: T C Cesario; P Schryer; A Mandel; J G Tilles
Journal: Proc Soc Exp Biol Med Date: 1976-12

2. Sepharose-bound poly (I)-poly (C): interaction with cells and interferon production.

Authors: L Bachner; E De Clercq; M N Thang
Journal: Biochem Biophys Res Commun Date: 1975-03-17 Impact factor: 3.575

3. Blue dextran-sepharose: an affinity column for the dinucleotide fold in proteins.

Authors: S T Thompson; K H Cass; E Stellwagen
Journal: Proc Natl Acad Sci U S A Date: 1975-02 Impact factor: 11.205

4. Interaction of interferon with tRNA.

Authors: M N Thang; J De Maeyer-Guignard; E De Maeyer
Journal: FEBS Lett Date: 1977-08-15 Impact factor: 4.124

5. Covalent coupling of ribonucleic acid to agarose.

Authors: D L Robberson; N Davidson
Journal: Biochemistry Date: 1972-02-15 Impact factor: 3.162

6. The structures of polyinosinic acid.

Authors: D Thiele; W Guschlbauer
Journal: Biophysik Date: 1973-05-30

7. A method for the large scale production of potent interferon preparations.

Authors: M G Tovey; J Begon-Lours; I Gresser
Journal: Proc Soc Exp Biol Med Date: 1974-07

8. Synthesis of polyguanylic acid by polynucleotide phosphorylase of Escherichia coli.

Authors: M N Thang; M Graffe; M Grunberg-Manago
Journal: Biochim Biophys Acta Date: 1965-09-06

9. [The chromophore of blue dextran: a powerful ligand for the purification of interferon by affinity chromatography].

Authors: J de Maeyer-Guignard; E de Maeyer
Journal: C R Acad Hebd Seances Acad Sci D Date: 1976-09-27

10. Binding of human interferons to immobolized Cibacron Blue F3GA: The nature of molecular interaction.

Authors: W J Jankowski; W von Muenchhausen; E Sulkowski; W A Carter
Journal: Biochemistry Date: 1976-11-16 Impact factor: 3.162

18 in total

1. Stable antiviral expression in BALB/c 3T3 cells carrying a beta interferon sequence behind a major histocompatibility complex promoter fragment.

Authors: I Seif; E De Maeyer; I Riviere; J De Maeyer-Guignard
Journal: J Virol Date: 1991-02 Impact factor: 5.103

Binding of mouse interferon to polynucleotides.

1. Affinity of human fibroblast interferon for blue dextran.

2. Sepharose-bound poly (I)-poly (C): interaction with cells and interferon production.

3. Blue dextran-sepharose: an affinity column for the dinucleotide fold in proteins.

4. Interaction of interferon with tRNA.

5. Covalent coupling of ribonucleic acid to agarose.

6. The structures of polyinosinic acid.

7. A method for the large scale production of potent interferon preparations.

8. Synthesis of polyguanylic acid by polynucleotide phosphorylase of Escherichia coli.

9. [The chromophore of blue dextran: a powerful ligand for the purification of interferon by affinity chromatography].

10. Binding of human interferons to immobolized Cibacron Blue F3GA: The nature of molecular interaction.

1. Stable antiviral expression in BALB/c 3T3 cells carrying a beta interferon sequence behind a major histocompatibility complex promoter fragment.

2. Studies on in vitro interferon induction capacity and interferon sensitivity of simian foamy viruses.

3. Interaction of the hepatic glucocorticoid-receptor complex with Affigel blue.

4. Inhibition of herpes simplex virus type 2-induced biochemical transformation by interferon.

5. Glycosylation of human leukocyte interferon: effects of tunicamycin.

6. Inactivation of interferons: halomethyl ketone derivatives of phenylalanine as affinity labels.

7. Studies on the mechanism of binding of serum albumins to immobilized cibacron blue F3G A.

8. Electrophoretically pure mouse interferon exerts multiple biologic effects.

9. Human leukocyte interferon: relationship between molecular structure and species specificity.

10. Hydrophobic affinity chromatography of nucleic acids and proteins.