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Literature DB >> 26928976

Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery.

Yanqi Ye¹, Jicheng Yu¹, Chao Wang¹, Nhu-Y Nguyen¹, Glenn M Walker¹, John B Buse², Zhen Gu¹.

Abstract

An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation. One MN patch can quickly reduce the blood-sugar levels (BGLs) of chemically induced type-1 diabetic mice and stabilize BGLs at a reduced level for over 10 h.

Entities: CellLine Chemical Disease Gene Species

Keywords: diabetes; drug delivery; microneedles; pancreatic cells; physiological signals

Mesh：

Substances：
Blood Glucose
Insulin

Year: 2016 PMID： 26928976 PMCID： PMC4998837 DOI： 10.1002/adma.201506025

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

34 in total

1. Action of salivary alpha-amylase on amylopectin and glycogen.

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Journal: Nature Date: 1952-11-01 Impact factor: 49.962

2. D-enzyme: a disproportionating enzyme in potato juice.

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3. Assessment for revascularization of transplanted pancreatic islets at subcutaneous site in mice with a highly sensitive imaging system.

Authors: R Nishimura; M Goto; S Sekiguchi; K Fujimori; A Ushiyama; S Satomi
Journal: Transplant Proc Date: 2011-11 Impact factor: 1.066

4. Diabetes: A smart insulin patch.

Authors: Omid Veiseh; Robert Langer
Journal: Nature Date: 2015-08-06 Impact factor: 49.962

5. Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery.

Authors: Jicheng Yu; Yuqi Zhang; Yanqi Ye; Rocco DiSanto; Wujin Sun; Davis Ranson; Frances S Ligler; John B Buse; Zhen Gu
Journal: Proc Natl Acad Sci U S A Date: 2015-06-22 Impact factor: 11.205

6. Multiple attach hypothesis of alpha-amylase action: action of porcine pancreatic, human salivary, and Aspergillus oryzae alpha-amylases.

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Journal: Arch Biochem Biophys Date: 1967-10 Impact factor: 4.013

7. Starting insulin therapy in patients with type 2 diabetes: effectiveness, complications, and resource utilization.

Authors: R A Hayward; W G Manning; S H Kaplan; E H Wagner; S Greenfield
Journal: JAMA Date: 1997-11-26 Impact factor: 56.272

8. Dissolving polymer microneedle patches for influenza vaccination.

Authors: Sean P Sullivan; Dimitrios G Koutsonanos; Maria Del Pilar Martin; Jeong Woo Lee; Vladimir Zarnitsyn; Seong-O Choi; Niren Murthy; Richard W Compans; Ioanna Skountzou; Mark R Prausnitz
Journal: Nat Med Date: 2010-07-18 Impact factor: 53.440

9. A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes.

Authors: Garth L Warnock; David M Thompson; R Mark Meloche; R Jean Shapiro; Ziliang Ao; Paul Keown; James D Johnson; C Bruce Verchere; Nilufar Partovi; Iain S Begg; Michelle Fung; Sharon E Kozak; Suet On Tong; Khalid M Alghofaili; Claire Harris
Journal: Transplantation Date: 2008-12-27 Impact factor: 4.939

10. Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapy.

Authors: Joo Eun Chung; Susi Tan; Shu Jun Gao; Nunnarpas Yongvongsoontorn; Soon Hee Kim; Jeong Heon Lee; Hak Soo Choi; Hirohisa Yano; Lang Zhuo; Motoichi Kurisawa; Jackie Y Ying
Journal: Nat Nanotechnol Date: 2014-10-05 Impact factor: 39.213

29 in total

Review 1. Glucose-Responsive Insulin and Delivery Systems: Innovation and Translation.

Authors: Jinqiang Wang; Zejun Wang; Jicheng Yu; Anna R Kahkoska; John B Buse; Zhen Gu
Journal: Adv Mater Date: 2019-08-18 Impact factor: 30.849

Review 2. Glucose-responsive insulin release: Analysis of mechanisms, formulations, and evaluation criteria.

Authors: Jianhai Yang; Zhiqiang Cao
Journal: J Control Release Date: 2017-01-31 Impact factor: 9.776

Review 3. Polymeric microneedles for transdermal protein delivery.

Authors: Yanqi Ye; Jicheng Yu; Di Wen; Anna R Kahkoska; Zhen Gu
Journal: Adv Drug Deliv Rev Date: 2018-01-31 Impact factor: 15.470

Review 4. Non-invasive delivery strategies for biologics.

Authors: Aaron C Anselmo; Yatin Gokarn; Samir Mitragotri
Journal: Nat Rev Drug Discov Date: 2018-11-30 Impact factor: 84.694

Review 5. Glucose-Responsive Microneedle Patches for Diabetes Treatment.

Authors: Guojun Chen; Jicheng Yu; Zhen Gu
Journal: J Diabetes Sci Technol Date: 2018-05-31

6. Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment.

Authors: Yuqi Zhang; Qiongming Liu; Jicheng Yu; Shuangjiang Yu; Jinqiang Wang; Li Qiang; Zhen Gu
Journal: ACS Nano Date: 2017-09-15 Impact factor: 15.881

Review 7. Microneedles for transdermal diagnostics: Recent advances and new horizons.

Authors: Gui-Shi Liu; Yifei Kong; Yensheng Wang; Yunhan Luo; Xudong Fan; Xi Xie; Bo-Ru Yang; Mei X Wu
Journal: Biomaterials Date: 2019-12-26 Impact factor: 12.479

Review 8. Bioresponsive transcutaneous patches.

Authors: Jicheng Yu; Yuqi Zhang; Anna R Kahkoska; Zhen Gu
Journal: Curr Opin Biotechnol Date: 2017-03-11 Impact factor: 9.740

9. Built-In Active Microneedle Patch with Enhanced Autonomous Drug Delivery.

Authors: Miguel Angel Lopez-Ramirez; Fernando Soto; Chao Wang; Ricardo Rueda; Sourabh Shukla; Cristian Silva-Lopez; Daniel Kupor; David A McBride; Jonathan K Pokorski; Amir Nourhani; Nicole F Steinmetz; Nisarg J Shah; Joseph Wang
Journal: Adv Mater Date: 2019-11-04 Impact factor: 30.849

10. Local delivery of checkpoints antibodies.

Authors: Chao Wang; Yanqi Ye; Zhen Gu
Journal: Hum Vaccin Immunother Date: 2016-09-26 Impact factor: 3.452