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Literature DB >> 27668759

Local delivery of checkpoints antibodies.

Chao Wang^1,2, Yanqi Ye^1,2, Zhen Gu^1,2,3.

Abstract

Immune checkpoint inhibitors (ICI) based cancer immunotherapy has recently attracted considerable interest in the field of cancer therapy. The relevant immunotherapeutic agents do not directly attack the tumor, but boost the body's immune system to recognize and kill cancer cells. In this commentary, recent efforts utilizing immunoengineering for local delivery of these immune checkpoint antibodies are introduced. Future opportunities and challenges in this research theme are also commented.

Entities: Disease

Keywords: biomaterials; cancer immunotherapy; drug delivery; immune checkpoint inhibitors; microneedle

Mesh：

Substances：

Year: 2016 PMID： 27668759 PMCID： PMC5287304 DOI： 10.1080/21645515.2016.1223000

Source DB: PubMed Journal: Hum Vaccin Immunother ISSN： 2164-5515 Impact factor: 3.452

33 in total

1. Melanoma in 2015: Immune-checkpoint blockade - durable cancer control.

Authors: Elizabeth I Buchbinder; F Stephen Hodi
Journal: Nat Rev Clin Oncol Date: 2016-01-20 Impact factor: 66.675

Review 2. Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling.

Authors: Andy J Minn; E John Wherry
Journal: Cell Date: 2016-04-07 Impact factor: 41.582

Review 3. The role of microneedles for drug and vaccine delivery.

Authors: Helen L Quinn; Mary-Carmel Kearney; Aaron J Courtenay; Maelíosa T C McCrudden; Ryan F Donnelly
Journal: Expert Opin Drug Deliv Date: 2014-07-14 Impact factor: 6.648

4. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma.

Authors: Michael A Postow; Jason Chesney; Anna C Pavlick; Caroline Robert; Kenneth Grossmann; David McDermott; Gerald P Linette; Nicolas Meyer; Jeffrey K Giguere; Sanjiv S Agarwala; Montaser Shaheen; Marc S Ernstoff; David Minor; April K Salama; Matthew Taylor; Patrick A Ott; Linda M Rollin; Christine Horak; Paul Gagnier; Jedd D Wolchok; F Stephen Hodi
Journal: N Engl J Med Date: 2015-04-20 Impact factor: 91.245

5. Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery.

Authors: Jicheng Yu; Yuqi Zhang; Yanqi Ye; Rocco DiSanto; Wujin Sun; Davis Ranson; Frances S Ligler; John B Buse; Zhen Gu
Journal: Proc Natl Acad Sci U S A Date: 2015-06-22 Impact factor: 11.205

6. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial.

Authors: Jonathan E Rosenberg; Jean Hoffman-Censits; Tom Powles; Michiel S van der Heijden; Arjun V Balar; Andrea Necchi; Nancy Dawson; Peter H O'Donnell; Ani Balmanoukian; Yohann Loriot; Sandy Srinivas; Margitta M Retz; Petros Grivas; Richard W Joseph; Matthew D Galsky; Mark T Fleming; Daniel P Petrylak; Jose Luis Perez-Gracia; Howard A Burris; Daniel Castellano; Christina Canil; Joaquim Bellmunt; Dean Bajorin; Dorothee Nickles; Richard Bourgon; Garrett M Frampton; Na Cui; Sanjeev Mariathasan; Oyewale Abidoye; Gregg D Fine; Robert Dreicer
Journal: Lancet Date: 2016-03-04 Impact factor: 79.321

Local delivery of checkpoints antibodies.

1. Melanoma in 2015: Immune-checkpoint blockade - durable cancer control.

Review 2. Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling.

Review 3. The role of microneedles for drug and vaccine delivery.

4. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma.

5. Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery.

6. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial.

7. Dissolving polymer microneedle patches for influenza vaccination.

Review 8. Combination cancer immunotherapy and new immunomodulatory targets.

Review 9. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations.

Review 10. Recent advances of cocktail chemotherapy by combination drug delivery systems.

Review 1. Advances in engineering local drug delivery systems for cancer immunotherapy.

2. Immunotherapy in head and neck squamous cell carcinoma: a narrative review.